DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP000131

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_311016.5	Gene:	AgaP_AGAP000131 / 1272138	VectorBaseID:	AGAP000131	Length:	1080	Species:	Anopheles gambiae

Alignment Length:	1004	Identity:	222/1004 - (22%)
Similarity:	358/1004 - (35%)	Gaps:	242/1004 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NYRL------PNTTEPESYNVELWTNV-----HNGDTEFNGTVNIDIRVLNET------------ 96
            :|||      ..|..|.||...:|..|     :|...|.| ..|:.||:.|.|
Mosquito   153 HYRLFIHPVFNETDHPFSYTGIVWVTVTSKKPNNKRIELN-VKNLKIRLENVTVLKSIRLTNNDF 216

  Fly    97 --------------SNITLHYRQTSNFEATIISR----------DVATPTAIPLTVTPELQREFL 137
                          |...|:.|:....:|.:.|:          |..|...:.:......::..:
Mosquito   217 DEDLDWDLSEEDLYSLPRLNRRRRRRRQADLPSKFYHHPVFPADDFVTIKILDIEFDESNEKMII 281

  Fly   138 VLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQH-FLATTQFESTNARHAFP 201
            .|     |.....:..:.:.:|:.|...:|.|.:|  ::.:|||..| ..|.|..|..|||..:|
Mosquito   282 FL-----GTEMKKDIYYIVKVNFFGNMTNDKGLYY--THYEDDGPDHRHFAATVLEPNNARRLYP 339

  Fly   202 CYDEPARRANFTITIHHDPSYTAISNM------PVNTAATSSGVTAFQTTPKMSTYLVAFIVSDF 260
            |.|:...|:.|.:.|.........|:|      |:.|.  ...|..:.||..:....:.|:|:|.
Mosquito   340 CMDDHNFRSPFELNIARKSDMNTASSMNLEMSEPMETG--DIVVDTYNTTDMVRASEIGFVVTDM 402

  Fly   261 ESTTGELNGIRQRV----FSRKGKQD--QQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDF 319
               ..|...|..||    |:|....:  :...:::|..|  .....|.||||....:....||:.
Mosquito   403 ---VPERYRITARVSLLAFTRTRYDENIKNATSVFSRAL--QIYEQYLGVPFPYEVIRYVTIPNI 462

  Fly   320 SAGAME-NWGLATYREQYM-----WWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLW 378
            .....| ..|:....|:.:     ::...:.:||.:      :.:|.|.::...|...|.....|
Mosquito   463 DHQTYEIKEGMVLSSEKRLIKTADYFPPLDKSINRE------VANELAKLFIHKLADYKNKETYW 521

  Fly   379 LKEGFATLFSYESNDIAFPLW-DTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTF 442
            |.|             :.||: :...:.::...||..|:|.|...        ....:....||
Mosquito   522 LHE-------------SLPLYLEALALRNMTTANSTTLDDFLLEG--------RLRSMREEMNT- 564

  Fly   443 SYAKPASVLYMFKNAW-TDKVFRTGLNKY-----LTKNQYT----SCD----EWDLFASFQESAD 493
                ..|.|.:|.|.| .|..|.  |.||     |....||    :.|    |:..:....||.|
Mosquito   565 ----KTSALNIFTNHWEEDTHFE--LVKYKGLSVLRMMNYTLGQRTFDRFVREYFRYRMESESID 623

  Fly   494 ELGFTLPAS------VDDIFS----SWSHQAGYPLLTVTRNYNAGTITITQKRYVANKTDTNSAT 548
            .:......|      .|.:|.    |||....||::.:.||...|...:.|.. :..:.:.....
Mosquito   624 VIDILNGGSGEGASRTDGVFHSFLYSWSSLEKYPIINIRRNNATGYYELRQIP-LPFEEEPAEQL 687

  Fly   549 WYVPLNFATANKYDYRDTSATHYLLNV---TE-----TVISDVEAS--SDDWIIVNIQNSGYYRT 603
            |.||:.|       ..||:...::..|   |:     ||.||...|  |..|||||....||||.
Mosquito   688 WTVPVTF-------INDTNQRLFVEKVRWLTDEENLLTVQSDCSTSNGSASWIIVNPSGIGYYRV 745

  Fly   604 LYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDR--------LSHSILLELLGYLT-N 659
            .|:..::..:...|..   .||     .|.|.|...:..|.        |::|:...::.:|. |
Mosquito   746 NYEPAHWIKLAHVLYG---NFH-----YLPYTTLAIIVDDALNLARLGLLNYSVAFNVVSFLKHN 802

  Fly   660 EQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKI--GVNEIPGEHYLNNYLRIV 722
            .:.|.||..|.:.|...........|:.:.:.|::.||...:::|  | ||.  .|| |..::.:
Mosquito   803 NEHYQPWKLALSNLEFVYHATEDLPSFRHVERFLEYLILSKYEEIQRG-NET--AHY-NPLIKEL 863

  Fly   723 LVSLACQVGSDDCYNQSANKLSEYLYNGTA---------IEATLKTQAYCAGLRSTTNEIYSRVQ 778
            :|..||::|...|..|........|.|.|.         :...|.|....:||..     :.||:
Mosquito   864 IVQWACKLGVTSCIEQHKALFQAILRNQTVSPFEQREERLHRILCTTIKYSGLAE-----WKRVE 923

  Fly   779 SDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTAS 843
            .....::|...:.:.|.||||:...|.:..:|.| |...:...||:.   :.:|.|.:::.|..:
Mosquito   924 QQYRETTDINYQRILIKSLGCTREISMIKRYLGL-LKHPHFRMYSKE---ILTAISENKVALKYT 984

  Fly   844 LEFLESNW---EAYANLSDSAKPLDAALRGIA---------------TYVVSEKQKTRLNALVDV 890
            |:||.:.|   ..|..|.|    :...||.|:               :|......|..|..:.|:
Mosquito   985 LDFLFNEWLDVRLYLTLQD----ISILLRSISNMNEFKMYEQIFFRYSYTFQTMDKEILKRMRDI 1045

  Fly   891 V---------------------EADGPSY 898
            :                     |.||..|
Mosquito  1046 IIKLMVWRQEIAPVIEFRPFDFERDGGEY 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	92/455 (20%)
		M1_APN_2	65..517	CDD:189008	112/536 (21%)
		ERAP1_C	591..886	CDD:288671	79/332 (24%)
AgaP_AGAP000131	XP_311016.5	GluZincin	153..614	CDD:301352	108/509 (21%)
AgaP_AGAP000131	XP_311016.5	ERAP1_C	733..1025	CDD:288671	76/316 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810