DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP005301

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_309093.4	Gene:	AgaP_AGAP005301 / 1270378	VectorBaseID:	AGAP005301	Length:	1133	Species:	Anopheles gambiae

Alignment Length:	1052	Identity:	213/1052 - (20%)
Similarity:	396/1052 - (37%)	Gaps:	228/1052 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIIS-RDVATP 121
            |||..:|..|.:.:..|:...|.:  |.|:|::.|..||:.:.||.:..:..|..::. :..|..
Mosquito   126 LPNNVKPNRYILTIHPNLTTLDVK--GQVSIELYVEKETNFVVLHAQDLNITEKALVGPKGFALK 188

  Fly   122 TAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFL 186
            ....|..||  :::..:.|:    |......|:|::|.:    .|.|   .:..:..|...:..|
Mosquito   189 ILRMLEYTP--RQQLYIETR----EKLRKKANYTLSIRW----HSKM---ILDQFEGDFDMKKTL 240

  Fly   187 ATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTA-----ATSSGVTA--FQT 244
            |.|..:..:.|.||||:|||..||.|.|::..|..:..:||..|...     ...:|:..  |..
Mosquito   241 AATVLKPGSTRKAFPCFDEPHLRAAFKISLFRDRFHIGLSNSIVQDTDDVGFYMGTGLLRDDFAE 305

  Fly   245 TPKMSTYLVAFIVSDFE------------------------------STTGELNG---------- 269
            ||.:....|::::|||.                              ||.|..||
Mosquito   306 TPPLPPDSVSWVISDFRRELLEPSAKYQKVNASGNGASAAGAGKVPPSTAGAGNGKSTPSKVTKT 370

  Fly   270 ------------IRQRVF------------------------------SRKGKQDQQEWALWSG- 291
                        :.:.:|                              ...|....:..|||:|
Mosquito   371 EKKPFRNLTAVLLSKNLFKLTNTAPTKEPTQIENDVTISAAESGPAVAKSNGTVLPEHDALWNGD 435

  Fly   292 -----------------------LLVESS------LASYFGVPFALPKLDQAGIPDFSAGAMENW 327
                                   .::.:|      |..:..|.:.|.|||...:|........:.
Mosquito   436 TALIRTAPAYSFYAPETHIAKGTFILHTSRDILEYLQQWLSVAYPLSKLDFVALPSLLDDLSSSL 500

  Fly   328 GLATYREQYMWWNKQNSTINLKTNIANI-IGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYES 391
            |:...|..::  |:..:..:.:.:::.: |.......:||.|:|.|.|.:.||.||   |..|.|
Mosquito   501 GIIVCRTSFL--NEPTAISSKEYHMSVVKISEGIVKQYFGGLISPKAWKHKWLWEG---LIRYLS 560

  Fly   392 NDIAF---PLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKPASVLYM 453
            ..:..   |||...::|.::....||..|||..    ...:...:..|...:.|...|.|::|.|
Mosquito   561 RFLLATIQPLWPMKELFLIDTLTKALDIDALQG----WESISAGASDSGDNDPFYVDKSAALLSM 621

  Fly   454 FKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPASVDDIFSSWSHQAGYPL 518
            .::|..::.||..|.|:|...|:.:.:..||:|...:..:...:     |.::.:.|::.|.:||
Mosquito   622 LQSAIGERNFRQCLGKFLKTYQFQTAEPSDLWAICAKQVNNSKY-----VREMMNQWTNTAAFPL 681

  Fly   519 LTVTRNYNAGTITITQKR---YVA----------------NKTDTNSA---------------TW 549
            |.||.|..:.|:..|..|   |:|                ..|.|..|               .|
Mosquito   682 LNVTMNGTSLTVRQTGFRPAEYLAIYDEPMEEIEREGEQGRSTTTTPAPVDATGKSGSGEAGSRW 746

  Fly   550 YVPLNF--------ATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYD 606
            ..|:::        .||.:.::::..:....||.:|.:|:....:  .||.:|...:||||.|||
Mosquito   747 VFPIHYITDVLNTNETAAEAEHKEQQSLIIWLNSSEVIITLNHTA--QWIKLNHGQTGYYRVLYD 809

  Fly   607 TQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANT 671
            ..|:..:...::.....|..::|..|:.|.:.....:.:.....:||:.|...|:::.|.....:
Mosquito   810 EANWAKLVEQMQINNAVFSTQDRVGLVSDIFTLCHANLIPCHAAMELISYFPKEKEWGPIVLGTS 874

  Fly   672 ILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCY 736
            .|..:.:.|:..:.|....::|::.:......:|.:: .||.. ...||.||:..|......:..
Mosquito   875 HLEKWRKILKYSECYLVLAEYVRQNLAKSIQVLGWDD-TGEDE-TKLLRPVLMLSAALWEESETI 937

  Fly   737 NQSANKLSEYLYNGTAIEATLKTQAYCAGLRSTTNEI-------YSRVQSDLLSSSDSTDRSLFI 794
            ..:...::.:..:...|...|::.||...:.|...:.       |..|:.:  .||...:|...:
Mosquito   938 KFAKGLVTNFTTHSIPIPPNLRSVAYIGSVLSGEFQYWQFCWDRYMTVRRE--KSSVLEERMELL 1000

  Fly   795 SSLGCSGST---SQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNW-EAYA 855
            .:||.:...   ::||..:       .:|...|...:| .|.:.:..|...:..||::.| :..:
Mosquito  1001 RALGVTKDAWLQNRLLSHV-------ITLPVFEIVQVL-EAIAGTPTGGAMACRFLQAKWFDFQS 1057

  Fly   856 NLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGP--SYINDDLSTTIDSRITSNFAWL 918
            .|..........:..|..|..::.....|.:||:.. .|||  ..:|..|||     :.:|..|:
Mosquito  1058 KLGRGTVQFARVISAITQYGSTKFDYDELKSLVERF-GDGPGLKLLNMTLST-----VAANVEWV 1116

  Fly   919 EVNRDPVLNWIE 930
            ..::..:.:|||
Mosquito  1117 SRSQASIYSWIE 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	102/511 (20%)
		M1_APN_2	65..517	CDD:189008	115/575 (20%)
		ERAP1_C	591..886	CDD:288671	57/305 (19%)
AgaP_AGAP005301	XP_309093.4	Peptidase_M1	126..611	CDD:279741	101/508 (20%)
		GluZincin	134..680	CDD:301352	115/574 (20%)
		ERAP1_C	794..1098	CDD:288671	61/316 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820