DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP012757

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_307174.4	Gene:	AgaP_AGAP012757 / 1268613	VectorBaseID:	AGAP012757	Length:	658	Species:	Anopheles gambiae

Alignment Length:	692	Identity:	241/692 - (34%)
Similarity:	360/692 - (52%)	Gaps:	64/692 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLLAVCSLQARLILPLSLDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVELWTNVH 76
            |.:|......|...|||.|....:|.  ....|||| |.:....|.||..:||.:||  |:.::.
Mosquito     1 IKMLRTALSLAAFWLPLILASAPVEI--VEKVATSR-DAHDDSRYLLPKVSEPINYN--LFLDIT 60

  Fly    77 NGD-TEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRD---VATPTAIPLTVTPELQRE-- 135
            |.| ..:||||.|..|...:.::..|      |.:..:|:.:   |..|....:.|...:..|
Mosquito    61 NYDFYSYNGTVEITFRYTGDQNHFYL------NSDGLVIATESIKVTGPDGTDVPVANVIYMEEF 119

  Fly   136 ----FLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNA 196
                |....:...||      .:.|.|::.....:::.|.|.|||...: ...:||||.||||.|
Mosquito   120 EQIYFGFRDRLQTGE------QYKIAISFLNNIGTELKGLYRSSYKAGN-TTRYLATTHFESTYA 177

  Fly   197 RHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAATSSGV-------TAFQTTPKMSTYLVA 254
            |..|||||||:.:|.|.:.|.|...|.|:||||........||       |.|.|||.|||||:|
Mosquito   178 RSVFPCYDEPSYKATFNVKIRHRSEYRALSNMPAINRYIKLGVTVGDYTETTFDTTPLMSTYLLA 242

  Fly   255 FIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVES--SLASYFGVPFALPKLDQAGIP 317
            |::|||::.:.|.:..|:...:..|      :||  ..|..|  :|.::||..:.|||:|...||
Mosquito   243 FVISDFKTLSHESDRFRESKVAHTG------YAL--EFLGNSLRTLENFFGRQYQLPKVDLIAIP 299

  Fly   318 DFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEG 382
            ||:.||||||||.|:||||:.:.:..:|...|.|||::|.||..|||||:.|:.:|||||||.||
Mosquito   300 DFAMGAMENWGLITFREQYLIYEEGVTTARTKQNIADLITHELTHMWFGNEVTPEWWTYLWLSEG 364

  Fly   383 FATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAKP 447
            ||..|.|.......|.|:.:|.|.||:.:|||..|..::...|::|...|:.:::.::...|||.
Mosquito   365 FARYFEYYITSQLEPTWNLWQQFIVNNVHSALSQDCNSNKRMMSYYATNPAVLNDLFDYVVYAKS 429

  Fly   448 ASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQE--SADELGFTLPASVDDIFSSW 510
            |||:.|.:|......||..||.||....|.:.....|:.|.::  :.|     ||||::.||.||
Mosquito   430 ASVIRMIQNVIGFDTFRQSLNDYLRSRSYLTTRPQYLYTSIEKFRTVD-----LPASIELIFESW 489

  Fly   511 SHQAGYPLLTVTRNYNAGTITITQKRY-VANKTDT--NSATWYVPLNFAT--ANKYDYRDTSATH 570
            ::..|||::||:.:....|:|.:|||: :.|:.||  .:..:|:|:|:.|  ....::.||:.|.
Mosquito   490 ANTPGYPVVTVSIDRTKRTLTASQKRFWMPNELDTPPQNMLFYIPVNYGTNVPTSTNFEDTTPTF 554

  Fly   571 YLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPR----NRAQ 631
            :|.....|....:||.. :|::||.|.:||||..||.:::..:...|.|:  :|..:    ||||
Mosquito   555 WLTPQDPTATVSLEAGV-EWVVVNKQQTGYYRVNYDDESWHKLIEVLNSE--QFEDQLPVINRAQ 616

  Fly   632 LLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTIL 673
            |:.|.........:.:.:.|.|:.||..|.:|.||:||...|
Mosquito   617 LVDDVANLARAGEVGYDVALSLMQYLERETEYIPWATAYNAL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	148/407 (36%)
		M1_APN_2	65..517	CDD:189008	170/472 (36%)
		ERAP1_C	591..886	CDD:288671	29/87 (33%)
AgaP_AGAP012757	XP_307174.4	Peptidase_M1	44..429	CDD:279741	149/407 (37%)
		M1_APN_2	51..496	CDD:189008	170/472 (36%)
		ERAP1_C	574..>658	CDD:288671	28/85 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25960
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830