DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP013188

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_003436573.1	Gene:	AgaP_AGAP013188 / 11175889	VectorBaseID:	AGAP013188	Length:	935	Species:	Anopheles gambiae

Alignment Length:	999	Identity:	292/999 - (29%)
Similarity:	467/999 - (46%)	Gaps:	110/999 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LLNSFSLILLLAVCSLQARLILPLSLD---------DGQLETKGAALFATSRVDDNSAGNYRLPN 60
            |....:|::|:...........||..|         ..|||                  :|||.:
Mosquito     3 LAEKLALVVLVTCACAVVSTASPLDPDRYFLVEAEPRAQLE------------------DYRLND 49

  Fly    61 TTEPESYNVE----LWTNVHNGDTEFNGTVNIDIRVLNE-TSNITLHYRQ--TSNFEATIISRDV 118
            ...|..|::|    |....:.....|:|:..|.:....: ...|.||..:  .|.:..|..|.:.
Mosquito    50 DVWPTHYDIEIKPYLEQEGNKAQFTFDGSAKITVSTQKQNVMQIKLHMARMDISAWSVTRKSDNT 114

  Fly   119 ATPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQ 183
            ..|| :|.|...|.|    :|| .....|..||..:.::..|.|....||.||| .||..:||.:
Mosquito   115 IIPT-LPQTYDQETQ----ILT-LPLSSALQANVEYVLSFTYVGNMDDDMHGFY-RSYYWEDGVK 172

  Fly   184 HFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP-VNTAATSSG--VTAFQTT 245
            .::.:|||:.|:||.||||:|||..:|.|.:.|:|...|...||.. |.||....|  :|.|..|
Mosquito   173 VWMGSTQFQQTHARRAFPCFDEPRFKATFQLKINHKTQYNVYSNTAIVGTAVAEVGRSLTTFGVT 237

  Fly   246 PKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPFA--- 307
            |.||:||:||||:.::....:..||    .:|...|:|.:::|..|:.:..:|..:...|:|
Mosquito   238 PSMSSYLIAFIVAPYQINDRDGMGI----LARPQAQNQTQYSLDVGIKLLKALEEWIDYPYASVA 298

  Fly   308 -LPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSI 371
             :.::..|.:|||||||||||||.||||..:.:...:||...:..||.:|.||.||.||||||:.
Mosquito   299 GMTRMYMAAVPDFSAGAMENWGLLTYRETNILYRSDDSTSMQQHRIAAVISHEIAHQWFGDLVTC 363

  Fly   372 KWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEIS 436
            :||...||.||||..:.|....:....||....|.|......:..|:|.|..||||.|.|.::.|
Mosquito   364 EWWDVTWLNEGFARYYQYYGTALVETEWDLDHQFVVEQLQGVMQMDSLRSTHPMTHPVYTQAQAS 428

  Fly   437 NRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESADELGFTLPA 501
            ..::..||.|.|.:|.|.::..|.:.|:|.|..|:....:.:....|||::...        ...
Mosquito   429 GIFDNISYNKGAVMLRMMEHYLTTETFKTALRAYIKDRAFKTTRPEDLFSALNR--------YDP 485

  Fly   502 SVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANKTDTNSAT-WYVPLNFAT-ANKYDY- 563
            :.......|:.|.||||:||| :::.| .||||||::.|:.|.|..| |.:|:.||| |:::..
Mosquito   486 NARSYMEPWTIQPGYPLVTVT-SHDTG-FTITQKRFLVNEPDHNEQTAWPLPITFATKASEFSIT 548

  Fly   564 RDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPW-RFHPR 627
            |....|.....:.....||||     :.|:|.|..||||..||...:|.|:.||.|:.: ..|..
Mosquito   549 RPAFYTGMTFEIPMQGASDVE-----YFILNNQQVGYYRVNYDAILWGKISKALHSEGFGGIHVL 608

  Fly   628 NRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDF 692
            ||||::.|.:.....|.:.:...||:|.||..|.:||||..|...||...|.:..||.    :.|
Mosquito   609 NRAQIVDDLFNLARGDVVPYGTALEILEYLKEETEYAPWLAAVNGLTTLSRRIHADDE----KLF 669

  Fly   693 VKRLIDPIFDK---IGVNEIP--GEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYN-GT 751
            ...::| ||.|   |...:.|  .|..:..|:|..::..||..|.::|...:..:...|..| ..
Mosquito   670 TAHILD-IFSKAYDIVKFQAPTATERRIFTYMRQNVLQWACNYGHEECSKAAVAEFHRYHQNPSV 733

  Fly   752 AIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLR----- 811
            .:...|:...||.|:|..:.|.:..:.:..|:::.:|::.|.:..|||..|:..:.|.|.
Mosquito   734 KVHPDLRQVVYCEGIRKGSTEEFEFLWNQYLTTNVATEQILILQGLGCVSSSELITDMLNGIASP 798

  Fly   812 --LSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWEA----YANLSDSAKPLDAALRG 870
              .|.|.||:.:|     ::|:.|:...:  :..|:...:||.|    |.|::       :|...
Mosquito   799 HVRSQDKNNAFTY-----VINNPYTLPHV--SRYLQQNHANWAASHGSYTNVA-------SAFNN 849

  Fly   871 IATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDSLKE 935
            :...:.|:.::..::|.::..:........|.:.:.::...|:....|. |||.:..::::  |.
Mosquito   850 VLARLKSDSERDAISAFIESNKNILGQAAYDSIKSGLEDYETNKQFTLR-NRDEIHEFLDN--KI 911

  Fly   936 NGSPSLTSSITTILVSAMALLLFR 959
            ||..:...:..:::|..:.|:|.|
Mosquito   912 NGGAATILANVSMIVGLLMLVLAR 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	141/402 (35%)
		M1_APN_2	65..517	CDD:189008	153/465 (33%)
		ERAP1_C	591..886	CDD:288671	83/312 (27%)
AgaP_AGAP013188	XP_003436573.1	Peptidase_M1	46..439	CDD:279741	141/403 (35%)
		M1_APN_2	54..501	CDD:189008	153/465 (33%)
		ERAP1_C	571..888	CDD:288671	85/335 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.820