DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP013146

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_003436568.1	Gene:	AgaP_AGAP013146 / 11175863	VectorBaseID:	AGAP013146	Length:	941	Species:	Anopheles gambiae

Alignment Length:	990	Identity:	280/990 - (28%)
Similarity:	475/990 - (47%)	Gaps:	97/990 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LILLLAVCSLQARLI--LPLS---LDDGQLETKGAALFATSRVDDNSAGNYRLPNTTEPESYNVE 70
            :::.|.:.:||...:  .||.   .|:..|:::       :::::     |||.:...|..|::|
Mosquito     9 ILVSLGLANLQRSTVSCTPLHSQLFDEVDLQSR-------AQLEE-----YRLNDDVWPTHYDIE 61

  Fly    71 LWTNVHNGDTE-----FNGTVNIDIRVLNE-TSNITLHYRQTSNFEATIISRDVATPTAIPLTVT 129
            : ......:.|     |:.|..|.:.||.: .:.|.||....:..:..::.:..:.|..   .|.
Mosquito    62 I-KPYFEPEPEKEAFTFDATTTIAVTVLKDNVTQIKLHKAHMNVTDWRVMRKSNSMPVG---KVN 122

  Fly   130 PELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFEST 194
            .....|..:.|..........|..:.|.:||.|....|||||| .||...:|:|.:|.:||||.|
Mosquito   123 ETYNEETQIWTLNLKPSELVKNVEYNIVVNYVGRMEEDMGGFY-RSYFKVNGKQVWLGSTQFEQT 186

  Fly   195 NARHAFPCYDEPARRANFTITIHHDP-SYTAISNMP-VNTAAT--SSGVTAFQTTPKMSTYLVAF 255
            .||.||||:|||..:..||:.:.:.| .|...:|.| ||:..|  :..:..|..||||||||:||
Mosquito   187 EARRAFPCFDEPRYKTTFTLKLDYKPDEYNVYANTPIVNSVPTRYNRTLATFGITPKMSTYLLAF 251

  Fly   256 IVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASYFGVPF-ALPKLDQ---AGI 316
            ||:.:|..:.::.|    |.:|....:|.::::..||.:..:|.::...|| ::|::.:   |.|
Mosquito   252 IVAPYELKSSDVMG----VLARPEALNQTDYSVQEGLKLLKALGNWVDYPFNSVPEITRMYMAAI 312

  Fly   317 PDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKE 381
            |||:|||||||||.||||..:.:.::::|...:..||:||.||.||.|||:||:.:||...||.|
Mosquito   313 PDFAAGAMENWGLITYRESSLLYVQEDATSMQQQRIASIISHELAHQWFGNLVTCEWWDVTWLNE 377

  Fly   382 GFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTHYVQTPSEISNRYNTFSYAK 446
            ||||.|.|....:..|||:....|.|....:|:..|...:..||||.|.|.::.:..::..||.|
Mosquito   378 GFATYFEYFGTALVEPLWELDVQFVVEKLQAAMQTDGSLATHPMTHTVYTQTQAAAMFDAISYNK 442

  Fly   447 PASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASF-QESADELGFTLPASVDDIFSSW 510
            ...||.|.::..:...|:..:.:|:...|:.:.....||... :.:|:...|..|         |
Mosquito   443 GGVVLRMLEHYLSPDAFQAAIREYVKDRQFATARPEQLFTVLDKRNANASAFMKP---------W 498

  Fly   511 SHQAGYPLLTVTRNYNAGTITITQKRYVANKTDT-NSATWYVPLNFATANKYDYRDTSAT----- 569
            :.|.|:||:|||.:.|.  :.:||||::||.||. ....|.:|:.||| .:.::..|:.|
Mosquito   499 TTQPGFPLVTVTSHGNG--VKLTQKRFIANGTDAEEKLLWPLPITFAT-KESEFESTTPTIVSSE 560

  Fly   570 -HYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPW-RFHPRNRAQL 632
             |   |:|...:|||.     :.|:|.|..||||..||...:..|.|||:|:.: ..|..||||:
Mosquito   561 SH---NITLANMSDVA-----YFILNNQQVGYYRVNYDEALWEKIGAALRSRAFGGIHVLNRAQI 617

  Fly   633 LYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTA-NTILTVYDRYLRGDDSYYNFQDFVKRL 696
            :.|.......|.|.:..:|:||.||..|.:||||..| |...::..|....|:..  |..::..:
Mosquito   618 VDDLLNLAKADVLGYGKVLDLLSYLKQEMEYAPWLAAFNGFASLAPRIHPDDEKL--FTQYLMDI 680

  Fly   697 IDPIFDKIGVNEIPGEH--YLNNYLRIVLVSLACQVGSDDCYNQSANKLSEY-LYNGTAIEATLK 758
            :..:::.:.. :.|.::  .|:.|||.:::...|:.|.|||...:..:...: .|.|..:...|:
Mosquito   681 LTDVYEYVKF-QAPTQYDRRLHTYLRRLVLDWTCRYGHDDCSKSAVKEFERFRTYPGVKVHPDLR 744

  Fly   759 TQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRL--SLDTNNSLS 821
            ...||.|:|..::|.:..:.:..|:::.:|::.|.:..:.|:.....:..|:.|  |.|..:...
Mosquito   745 QVVYCEGVRKGSSEQFDFLLNIFLTTNVATEQQLTLFGMSCAPKEETVNKFMNLVSSADVRSQDK 809

  Fly   822 YSERTSLLNSAYSRSEIGLTASLEFLESNWEAYANLSDSAKPLDAALRGIATYVVSEKQKTRLNA 886
            .|..:.|||:.::     |..:..:|..|...:|......:.:..||.||...|.....:|.:..
Mosquito   810 ASALSMLLNNQHA-----LEPAASYLVQNSARWAEAHGGYRHVAMALGGILGRVNDVSVRTSIEQ 869

  Fly   887 LVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRDPVLNWIED-----SLKENGSPSLTSSIT 946
            ..:..:        |.|.......|.|.....:.|::..:|..|:     |.|.....|.|....
Mosquito   870 FAEASK--------DVLGREAYELIASGLIQFDYNQNFTMNHREEIRGFLSQKAGSGASATVIYN 926

  Fly   947 TILVSAMAL-LLFRL 960
            .::...:.| ::||:
Mosquito   927 VVVALCVTLAVVFRV 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	139/402 (35%)
		M1_APN_2	65..517	CDD:189008	151/466 (32%)
		ERAP1_C	591..886	CDD:288671	77/301 (26%)
AgaP_AGAP013146	XP_003436568.1	Peptidase_M1	48..443	CDD:279741	139/403 (34%)
		M1_APN_2	56..505	CDD:189008	151/466 (32%)
		ERAP1_C	575..879	CDD:288671	78/319 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	4	3.920