DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and AgaP_AGAP013150

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_003436699.1	Gene:	AgaP_AGAP013150 / 11175624	VectorBaseID:	AGAP013150	Length:	939	Species:	Anopheles gambiae

Alignment Length:	894	Identity:	290/894 - (32%)
Similarity:	466/894 - (52%)	Gaps:	67/894 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 YRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLH-----------YRQTSNF 109
            ||||:...|..|.:.|.|.||.|:..::|:|:|.:.:..:...|.:|           |....|.
Mosquito    50 YRLPSYIVPTHYKLYLETQVHTGNRSYSGSVDIHLDIRQQAKTIYVHQRGLRITSNELYASNPNT 114

  Fly   110 EATIISRDVATPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGFYIS 174
            ..|.:.         .|..|.:.:|||.|.....|    .|..::.:.:::.|..|.|..|||:|
Mosquito   115 NLTFLE---------TLRYTEDAEREFAVFAIRRA----LAPASYVLHLDFEGELRVDDDGFYLS 166

  Fly   175 SYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPVNTAA---TS 236
            ||.|.:|.:.::|:|||::.:||.||||.||||.:|...:.|.|.|||.|:||||:...|   ..
Mosquito   167 SYLDANGTRKYVASTQFQAISARAAFPCLDEPALKATVELGIKHHPSYKAVSNMPIFAEAGDLDG 231

  Fly   237 SGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSLASY 301
            :.||.|:|||:||.||:||:||||..|..|  ...|||::|....:|..:||.:|:.|..:|..:
Mosquito   232 NVVTYFETTPRMSIYLLAFLVSDFLYTENE--AAAQRVYARPNAINQTLYALEAGVRVMDALDEH 294

  Fly   302 FGVPFA--LPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHEYAHMW 364
            .|:|:.  :||:||..:..|||||||||||..|||:.:.:....:|...:|.|..||.|||.|.|
Mosquito   295 IGLPYRSYMPKVDQVALTQFSAGAMENWGLCKYREEVLLFEPGVTTYRAQTTITTIIAHEYVHQW 359

  Fly   365 FGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMT-HY 428
            ||::::.:||:||||.||||||:.:...|:|:|......:|:|......|:.||..|..||| ..
Mosquito   360 FGNVITNEWWSYLWLNEGFATLYEFLGADMAYPERQYRDLFNVQVVQRVLITDAAESTRPMTFSR 424

  Fly   429 VQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQESAD 493
            ..|.:.|.:.::..:|:|..|||.||:....|..:|..|..|:..|::.:.:..:..|:..|:.|
Mosquito   425 GATFNAILSLFDNVAYSKGGSVLQMFRLLLPDAAWRQMLRTYVQGNEFGTVNTDNFVAALTEAFD 489

  Fly   494 ELGFTLP--ASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANKTDTNSAT-WYVPLNF 555
            .: .:||  ..|:....||.:|||||:|.|.|:|. |.:.::|.|:..||...|..| |.:|  :
Mosquito   490 GV-VSLPEGTDVERFVHSWVNQAGYPVLEVRRSYR-GEMILSQDRFYGNKIVNNDFTVWVIP--Y 550

  Fly   556 ATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQ 620
            ....:.|.:| :...:....::.|.......:::||:||:..:|:||..||..|:.::...|...
Mosquito   551 TMMEQGDAQD-ALLEWQWMTSKAVRVPSSTPNNEWILVNVNQTGFYRVNYDPSNWYMLIRTLLED 614

  Fly   621 PWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDS 685
            .......:||||:.|::....::||...|.||||||:.:|::|.||..||.:|:.:...:||...
Mosquito   615 TAAIPMHSRAQLIDDSFHLARSNRLDLEIALELLGYVRHEREYPPWEAANRVLSYFHGRMRGQPD 679

  Fly   686 YYNFQDFVKRLIDPIFDKIGVNEI-PGEHYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLYN 749
            |..::.||..||..:|..:.:..: |.|..|..|||.|:.|.||::..:.|...:.:.|...:::
Mosquito   680 YILYELFVDTLIGDVFVTLDITTVAPDERLLEKYLRQVISSWACRMEIESCMTATRDALEREVFD 744

  Fly   750 GTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSL 814
            ...:...:....||.|||:.....:..:...||.|.:..:|.|.|::|||:..|.||..:|..::
Mosquito   745 AEPVHPDVSAVVYCYGLRTAPTVAFQYLFGKLLGSDNRGERQLLINALGCANDTEQLSSYLLAAI 809

  Fly   815 DTNNSLSYS--ERTSLLNSAYSRSEIGLTASLEFLESNW---------EAYANLSDSAKPLDAAL 868
            .....::::  ||.|:|.|..| |..|:.|.:|||..|:         .|.|||          :
Mosquito   810 GGELQVNFNAEERLSILQSVLS-SRQGVDALIEFLTENYTYVVSLLGPNALANL----------V 863

  Fly   869 RGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAW 917
            :.|||...:..::..|.||::.:.:..|:.::....||    .:.|.||
Mosquito   864 QSIATSTNTLDEEQMLIALLEQLNSVLPANVSASARTT----ASINLAW 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	150/405 (37%)
		M1_APN_2	65..517	CDD:189008	168/470 (36%)
		ERAP1_C	591..886	CDD:288671	90/306 (29%)
AgaP_AGAP013150	XP_003436699.1	Peptidase_M1	51..443	CDD:279741	150/406 (37%)
		M1_APN_2	59..514	CDD:189008	168/470 (36%)
		ERAP1_C	585..892	CDD:288671	92/317 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	190	1.000	Domainoid score	I6801
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	569	1.000	Inparanoid score	I2591
OMA	1	1.010	-	-		QHG25960
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm9691
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	1	0.960	-	-
	12	11.940