DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and AgaP_AGAP013255

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_003436572.1	Gene:	AgaP_AGAP013255 / 11175602	VectorBaseID:	AGAP013255	Length:	935	Species:	Anopheles gambiae

Alignment Length:	950	Identity:	287/950 - (30%)
Similarity:	459/950 - (48%)	Gaps:	103/950 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 NYRLPNTTEPESYNVE----LWTNVHNGDTEFNGTVNIDIRVLNE-TSNITLH--------YRQT 106
            :|||.:...|..|::|    |....:.....|:|:..|.:....: ...|.||        :..|
Mosquito    44 DYRLNDDVWPTHYDIEIKPYLEQEGNKAQFTFDGSAKITVSTQKQNVMQIKLHMARMDITAWSVT 108

  Fly   107 SNFEATIISRDVATPTAIPLTVTPELQREFLVLTQTTAGEAFGANTNWTITINYTGIHRSDMGGF 171
            ...:.|||      || :|.|...|.|    :|| .....|..||..:.::..|.|....||.||
Mosquito   109 RKSDNTII------PT-LPQTYDQETQ----ILT-LPLSSALQANVEYVLSFTYVGNMDDDMHGF 161

  Fly   172 YISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMP-VNTAAT 235
            | .||..:||.:.::.:|||:.|:||.||||:|||..:|.|.:.|:|...|...||.. |.||..
Mosquito   162 Y-RSYYWEDGVKVWMGSTQFQQTHARRAFPCFDEPRFKATFQLKINHKTQYNVYSNTAIVGTAVA 225

  Fly   236 SSG--VTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKGKQDQQEWALWSGLLVESSL 298
            ..|  :|.|..||.||:||:||||:.::....:..||    .:|...|:|.:::|..|:.:..:|
Mosquito   226 EVGRSLTTFGVTPSMSSYLIAFIVAPYQINDRDGMGI----LARPQAQNQTQYSLDVGIKLLKAL 286

  Fly   299 ASYFGVPF----ALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIGHE 359
            ..:...|:    |:.::..|.:|||||||||||||.||||..:.:...:||...:..||.:|.||
Mosquito   287 DEWLDYPYASMPAMTRMYMAAVPDFSAGAMENWGLLTYREANILYRSDDSTSMQQQRIATVISHE 351

  Fly   360 YAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVP 424
            .||.||||||:.:||...||.||||..:.|.:..:....||....|.|....|.:..|:|.|..|
Mosquito   352 IAHQWFGDLVTCEWWDVAWLNEGFARYYEYYATALVETNWDFEDQFVVAQLQSVMQMDSLRSTHP 416

  Fly   425 MTHYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLTKNQYTSCDEWDLFASFQ 489
            |||.|.|.:|.|..:::.:|.|.|.||.|.::..|.:.|:|.|..|:....:.:....|||::..
Mosquito   417 MTHPVYTQAESSAIFDSITYNKGAVVLRMMEHYLTTETFKTALRAYIKDRAFKTTRPEDLFSALN 481

  Fly   490 ESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVANKTDTNSAT-WYVPL 553
            .        ...:.......|:.|.||||:||| :::.| .|:||||::.|:.|.|..| |.:|:
Mosquito   482 R--------YDPNARSYMEPWTVQPGYPLVTVT-SHDTG-FTVTQKRFLVNEPDHNEQTAWPLPI 536

  Fly   554 NFAT-ANKYDY-RDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDTQNYGLITAA 616
            .||| |:::.. |....|.....:.....||||     :.|:|.|..||||..||...:|.|:.|
Mosquito   537 TFATKASEFSITRPAFYTGMTFEIPMQGASDVE-----YFILNNQQVGYYRVNYDAILWGKISKA 596

  Fly   617 LKSQPW-RFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTILTVYDRYL 680
            |.|:.: ..|..||||::.|.:.....|.:.:...||:|.||..|.:||||..|...||...|.:
Mosquito   597 LHSEGFGGIHVLNRAQIVDDLFNLARGDVVPYGTALEILEYLKEETEYAPWLAAVNGLTTLSRRI 661

  Fly   681 RGDDSYYNFQDFVKRLIDPIFDK---IGVNEIP--GEHYLNNYLRIVLVSLACQVGSDDCYNQSA 740
            ..||.    :.|...::| ||.|   |...:.|  .|..:..|:|..::..||..|.::|...:.
Mosquito   662 HADDE----KLFAAHILD-IFSKAYDIVKFQAPTATERRIFTYMRQNVLQWACNYGHEECSKAAV 721

  Fly   741 NKLSEYLYN-GTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFISSLGCSGSTS 804
            .:...|..| ...:...|....||.|:|..:.|.:..:.:..|:::.:|::.|.:..|||: |:|
Mosquito   722 AEFHRYHQNPSVKVHPDLGQVVYCEGIRKGSMEEFEFLWNQYLTTNMATEQLLILQGLGCA-SSS 785

  Fly   805 QLLDFLR--------LSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESN---WEA----Y 854
            :|:..:.        .|.|.:|:.:|     ::|:.|:...:.     .:|:.|   |.|    |
Mosquito   786 ELITIMLDAITSPHVRSQDKSNAFTY-----VINNLYTLPHVS-----RYLQQNHAIWAASHGSY 840

  Fly   855 ANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLE 919
            ||::       :|...:...:.|:.::..::|.::..:........|.:.|.::...|:....|.
Mosquito   841 ANVA-------SAFNNVLARLKSDSERDVISAFIESNKNILGQAAYDSIKTGLEDYETNKQFTLR 898

  Fly   920 VNRDPVLNWIEDSLKENGSPSLTSSITTILVSAMALLLFR 959
             |||.:..::::  |.||..:...:..:::|..:.|||.|
Mosquito   899 -NRDEIHEFLDN--KINGGAATILANVSMIVGLLMLLLAR 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	143/408 (35%)
		M1_APN_2	65..517	CDD:189008	156/471 (33%)
		ERAP1_C	591..886	CDD:288671	83/316 (26%)
AgaP_AGAP013255	XP_003436572.1	Peptidase_M1	46..439	CDD:279741	143/409 (35%)
		M1_APN_2	54..501	CDD:189008	156/471 (33%)
		ERAP1_C	571..888	CDD:288671	86/339 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	5	4.820