DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31343 and enpep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_002934295.1	Gene:	enpep / 100494326	XenbaseID:	XB-GENE-977050	Length:	965	Species:	Xenopus tropicalis

Alignment Length:	923	Identity:	271/923 - (29%)
Similarity:	458/923 - (49%)	Gaps:	92/923 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DNSAGN---YRLPNTTEPESYNVELWTNVHNGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEA 111
            |:|.|:   :|||....|..|||||.. |...|| :||||:|.:|:...:.::.||.|:|.....
Frog    89 DDSNGDWKEFRLPTYINPVHYNVELHP-VMEQDT-YNGTVSIWLRLSKTSKHLWLHLRETKIIGQ 151

  Fly   112 TIISRDVATPTAIPLTVTPE-LQREFLVLTQTTA---GEAFGANTNWTITINYTGIHRSDMGGFY 172
            ..::|.   ...||:....: :..|:|||.....   ......|..:.:|:.:.|.....:.|||
Frog   152 LTLTRG---SQQIPIQQCFQYIPNEYLVLEAQQVLDPNSPTDENDTYCLTLQFAGRLDGSLVGFY 213

  Fly   173 ISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISNMPV-NTAATS 236
            .::| .::|....:|....|.|:||.:|||:|||.::|.:||:|.|...|.||||||| .:.|..
Frog   214 RTTY-QENGVTKSIAAADHEPTDARKSFPCFDEPNKKATYTISIIHREEYDAISNMPVQESVALG 277

  Fly   237 SG--VTAFQTTPKMSTYLVAFIVSDFESTTG-ELNGIRQRVFSRKGKQDQQEWALWSGLLVESSL 298
            :|  .|.|:.:..||||||.|.|..|:.... ...|:..|::.:..:....|:|..:..:|....
Frog   278 NGWKRTLFEKSVPMSTYLVCFAVHQFKYVERLSKRGVPLRIYVQPLQNATAEYAANTTKIVFDFF 342

  Fly   299 ASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWN-KQNSTINLKTNIANIIGHEYAH 362
            ..||.:|::||||||..||||..||||||||.||||..:.:: .:::|:| |..:|.:|.||..|
Frog   343 EEYFNMPYSLPKLDQIAIPDFGTGAMENWGLITYRETNLLYDPNESATVN-KQRVAAVIAHELVH 406

  Fly   363 MWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASAVPMTH 427
            .|||::|::.||..|||.||||:.|.|...|.|.|||:......::|....:.:|||.|:.|:..
Frog   407 QWFGNIVTMDWWDDLWLNEGFASFFEYSGVDAAEPLWNMLDQILIDDLLPVMRDDALLSSHPIIV 471

  Fly   428 YVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTG----LNKYLTKNQYTSCDEWDLFASF 488
            .|.||:||::.::..||.|.||:|.|.::..:.:.|:.|    |..|:.||..|. |.|:..|.
Frog   472 TVSTPAEITSVFDAISYNKGASILRMLEDWISPENFKKGCQDYLKDYVFKNAKTD-DFWNSLAK- 534

  Fly   489 QESADELGFTLPAS---VDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYV----ANKTDTNS 546
                        ||   |.::..:|:.|.|||:|.| .:.|    |:.|.|::    ||..:..|
Frog   535 ------------ASGKPVKEVMDTWTRQMGYPVLNV-ESLN----TVKQTRFLLDPNANALEPPS 582

  Fly   547 A---TWYVPLNF-ATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYDT 607
            .   .|.:|:.| ||.|..||...........::.|..:|   ::|.::.:|.::.|::|..|:.
Frog   583 EFNYMWNIPVTFYATNNSVDYNLLYNKSIPAGLSLTPFND---ATDGFLKINTRHLGFFRVNYEL 644

  Fly   608 QNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANTI 672
            ..:..::|.|::....|...:||.|:.|.:.....::|.::|.|::..||..|..|..|:.|.:.
Frog   645 STWNQLSALLEANHETFTDADRAGLIDDAFALARAEKLDYNISLDITKYLEKETNYLTWTRAISS 709

  Fly   673 LTVYDRYLRGDDSYY-NFQDFVKRLIDPIFDKIGVNEIPGEHYLNNYLRIVLVSLACQVGSDDCY 736
            |......|..|::.| .||:::::.:.||..|.|..:...:  ::..||..:::|:|::|..|..
Frog   710 LAYLSDMLEDDNTIYPKFQEYLRKQVKPITQKHGWEDTGSD--IDKLLRASVLALSCKMGDPDAL 772

  Fly   737 NQSANKLSEYLYNGTAIEATLKTQAYCAGLRSTTN-EIYSRVQSDLLSSSDSTDRSLFISSLGCS 800
            |:::....::: .|.:|...|:...|..|::.:.| |.::.:....|::|.:.::...:..| .|
Frog   773 NEASRLFRDWI-GGKSIPVNLRQLVYRYGMQQSGNQESWNYMFQQYLTTSLAQEKEKLLQGL-AS 835

  Fly   801 GSTSQLLD-FLRLSLDTNNSLSYSERTSLLNSAY---SRSEIGLTASLEFLESNWEAYANLSDSA 861
            .:..:|:| :|:|..  |.||..|:  ..||..|   ..|:.|...:.:::..||:   .|.|..
Frog   836 ANNIELIDRYLKLIY--NTSLIKSQ--DALNVIYYISVYSQYGKQMAWDWVRINWD---YLVDRY 893

  Fly   862 KPLDAALRGIATYVVSE-KQKTRLNALVDVVEADGPSYIN---------DDLSTTIDSRITSNFA 916
            ...|..|..|.|.:... ...|:|..:.:..|    .|.|         ..|.|     :.:|..
Frog   894 NINDRNLGRIVTRISGTFNTATQLWQMENFFE----KYPNAGAGEIPRKQALET-----VRNNIE 949

  Fly   917 WLEVNRDPVLNWI 929
            |:..|::.:.:|:
Frog   950 WVAANKEGIKSWL 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	145/397 (37%)
		M1_APN_2	65..517	CDD:189008	162/467 (35%)
		ERAP1_C	591..886	CDD:288671	71/301 (24%)
enpep	XP_002934295.1	M1_APN-Q_like	107..549	CDD:341064	160/462 (35%)
enpep	XP_002934295.1	ERAP1_C	627..946	CDD:378732	76/338 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920