DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and anpep

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_031755081.1	Gene:	anpep / 100492262	XenbaseID:	XB-GENE-981369	Length:	977	Species:	Xenopus tropicalis

Alignment Length:	949	Identity:	280/949 - (29%)
Similarity:	466/949 - (49%)	Gaps:	89/949 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKGAALFATSRVDDNSAGNYRLPNTTEPESYNVELWT-NVHNGD--TEFNGTVNIDIRVLNETSN 98
            |..|...||:...::....||||.|..|..|:|||.. .|.|.|  ..|.|. :....:.|:.::
Frog    64 TATATATATTAQSNDPWNKYRLPKTLSPVHYDVELQPFLVKNADGLYVFRGK-STAFFICNDATD 127

  Fly    99 I------TLHYRQTSNFEATIISRDVATPTAIPLTVTPELQREFLVLTQTTA----GEAFGANTN 153
            :      .|::.:.::|:|.:  :|.||..|:..|.. :..::|||: |..|    |:.:|..|
Frog   128 LIIIHSNKLNHTKFNSFDAKL--QDGATDVALKSTFF-QKDKQFLVV-QAAANLVPGKQYGLYT- 187

  Fly   154 WTITINYTGIHRSDMGGFYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHH 218
                 .:.|....|:.|||.|.|. :||....:||||.::.:||.||||:||||.:|.|.||:.:
Frog   188 -----EFVGELADDLAGFYRSEYL-EDGVTKIIATTQMQAPDARKAFPCFDEPAMKATFNITLKY 246

  Fly   219 DPSYTAISNMPV--NTAATSSG----VTAFQTTPKMSTYLVAFIVSDFEST----TGELNGIRQR 273
            ...|.|:|||..  .:..|..|    |:.|..|||||:||||||||:||:.    ...:.|:  :
Frog   247 RQPYKAMSNMREIDRSTVTEDGQQWTVSKFDKTPKMSSYLVAFIVSEFEAVGDPGNATVTGV--Q 309

  Fly   274 VFSRK---GKQDQQEWALWSGLLVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQ 335
            ::.||   ..::|.|:||.....:....|.|:..|:.|||.||..:|||||||||||||.||||.
Frog   310 IWGRKKAIQDENQGEYALSVTKPILDFFAEYYRTPYPLPKSDQVALPDFSAGAMENWGLVTYRET 374

  Fly   336 YMWWNKQNSTINLKTNIANIIGHEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWD 400
            .:.::.|.|:|..|..:..:|.||.||.|||:||:|:||..|||.||||:...|...|.|.|.|:
Frog   375 ALLFDDQVSSIGNKERVVTVIAHELAHQWFGNLVTIRWWNDLWLNEGFASYVEYLGADKAEPNWN 439

  Fly   401 TYQIFHVNDYNSALLNDALASAVPMT---HYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKV 462
            ...:..:||.:..:..|||||:.|:|   ..|.:|||||..:::.:|:|.|||:.|.....|:.:
Frog   440 IKDLIVLNDVHRVMAVDALASSHPLTSREDEVNSPSEISALFDSIAYSKGASVIRMLSEFLTEPL 504

  Fly   463 FRTGLNKYLTKNQYTSCDEWDLFASFQESA-DELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYN 526
            |..||..||...:|::....||:...|.:. ::....||..:.||..:|..|.|:|::.:    :
Frog   505 FVDGLASYLKGFEYSNTVYSDLWTHLQWAVNNQTAVKLPLPIKDIMDTWVLQMGFPVVKI----D 565

  Fly   527 AGTITITQKRY------VANKTDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEA 585
            ..|..:|||.:      |..:.......|.||:::..::|.|      ..:|.|.:||| .|.:.
Frog   566 TATGVVTQKHFLLDPDSVVTRPSPFDYKWKVPISYKISSKED------NIWLQNESETV-EDFKI 623

  Fly   586 SSDDWIIVNIQNSGYYRTLYDTQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSIL 650
            :.:||::||:..:||||..||..|:..:...|::........||||::.|.:......:::....
Frog   624 TGNDWLLVNLNVTGYYRVNYDDNNWSRLLNQLQTSHQAIPVINRAQIIDDAFNLARAKQITTIQA 688

  Fly   651 LELLGYLTNEQQYAPWSTANTILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGVNEIPGE--- 712
            |:...|::.:::|.||..|.:.|:.:.:.....:.:...:.::|..::|:|:..  .:..|.
Frog   689 LDTTKYISADREYMPWQAALSGLSYFTQMFDRTEVFGPMKKYMKMQVNPLFEYF--KQETGNWTN 751

  Fly   713 ---HYLNNYLRIVLVSLACQVGSDDCYNQSANKLSEYLY--NGTAIEATLKTQAYCA----GLRS 768
               ...:.|..|..:|.||....:||...::...|:::.  ....|...|:|..||.    |...
Frog   752 RPVSLTDQYCEINTLSTACSYDIEDCLKFASELFSQWMATPQQNNIHPNLRTNVYCTAVAQGGEQ 816

  Fly   769 TTNEIYSRVQ-SDLLSSSDSTDRSLFISSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSA 832
            ..|.::.|.| :|:....|.     ..::|.||.....|..||..|||. ..:...:..|.::|.
Frog   817 EWNFVWDRFQLTDIAQEQDK-----LRAALACSKEPWILNRFLEYSLDP-TMIRRQDAVSTISSV 875

  Fly   833 YSRSEIGLTASLEFLESNWEA-YANLSDSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGP 896
            .: :.||.:.:.:|:.:.|:. |:...:|:......:..:.....:|.:..:|  |....:...|
Frog   876 VN-NPIGQSLAWDFVRAKWKTLYSMFGESSFSFGNLIERVTRRFSTEFELQQL--LQFKADNQNP 937

  Fly   897 SY--INDDLSTTIDSRITSNFAWLEVNRDPVLNWIEDSL 933
            .:  .:..|...|: :..:|..|:..|:..|..|.||::
Frog   938 GFGTASQALEQAIE-KTKANINWVNQNKAAVKKWFEDAV 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	159/417 (38%)
		M1_APN_2	65..517	CDD:189008	176/481 (37%)
		ERAP1_C	591..886	CDD:288671	64/308 (21%)
anpep	XP_031755081.1	M1_APN-Q_like	92..555	CDD:341064	174/476 (37%)
anpep	XP_031755081.1	ERAP1_C	628..955	CDD:403137	69/338 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110