DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31343 and LOC100004744

DIOPT Version :9

Sequence 1:	NP_732652.1	Gene:	CG31343 / 326133	FlyBaseID:	FBgn0051343	Length:	961	Species:	Drosophila melanogaster
Sequence 2:	XP_001920418.2	Gene:	LOC100004744 / 100004744	-ID:	-	Length:	935	Species:	Danio rerio

Alignment Length:	916	Identity:	264/916 - (28%)
Similarity:	445/916 - (48%)	Gaps:	73/916 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 YRLPNTTEPESYNVELWTNVH---NGDTEFNGTVNIDIRVLNETSNITLHYRQTSNFEATIISRD 117
            ||||:|..|..||:.||..:.   :|...|.|..::..:.|.||..|.:|..:.:     :.|.|
Zfish    46 YRLPDTLFPHYYNITLWPRLQPDDHGLYVFTGNSSVVFKCLRETDIIIIHCNKLN-----LTSED 105

  Fly   118 --VATPTAIPLTVTPELQR-------EFLVLT---QTTAGEAFGANTNWTITINYTGIHRSDMGG 170
              :|..:|...:..|.:::       ::|||.   :..|||.:      .:...:.|....|:.|
Zfish   106 GYLAKLSAFSTSEVPSVKKTWIEEMTQYLVLQLNGKLKAGELY------VLYTEFVGELADDLAG 164

  Fly   171 FYISSYTDDDGEQHFLATTQFESTNARHAFPCYDEPARRANFTITIHHDPSYTAISN-MPVNTAA 234
            .|.|.| |:|||:..:||:|...|:||..|||:||||.:|.|.||:.||....|:|| |.:....
Zfish   165 LYRSEY-DEDGEKKIVATSQMHPTHARKTFPCFDEPAMKAVFHITLIHDRGTVALSNGMEIENVD 228

  Fly   235 T-----SSGVTAFQTTPKMSTYLVAFIVSDFESTTGELNGIRQRVFSRKG--KQDQQEWALWSGL 292
            |     ...||.|:.|..||:||:|.:|||:.:.| ..:|...|:::||.  :....::||....
Zfish   229 TIVDGQPVTVTTFEPTKIMSSYLLALVVSDYTNVT-SADGTLIRIWARKKAIEDGHGDYALNITG 292

  Fly   293 LVESSLASYFGVPFALPKLDQAGIPDFSAGAMENWGLATYREQYMWWNKQNSTINLKTNIANIIG 357
            .:.....:|:.||:.|.|.||..:|||..||||||||..|||..:.::...|:...|...|.||.
Zfish   293 PILKFFENYYNVPYPLSKSDQIALPDFYFGAMENWGLVMYRESNLLYDPTVSSNANKERTATIIA 357

  Fly   358 HEYAHMWFGDLVSIKWWTYLWLKEGFATLFSYESNDIAFPLWDTYQIFHVNDYNSALLNDALASA 422
            ||.||||||:||::|||..:||.||||:..||...|.|.|.|:...:..:.|.:.....|||||:
Zfish   358 HELAHMWFGNLVTLKWWNEVWLNEGFASYVSYLGADFAEPSWNVKDLIILKDVHRVFAVDALASS 422

  Fly   423 VPMT---HYVQTPSEISNRYNTFSYAKPASVLYMFKNAWTDKVFRTGLNKYLT--KNQYTSCDEW 482
            .|::   ..:..|.:|..:::|.||:|.||||.|..:..|:.||..|||.|||  .:|.|..:
Zfish   423 HPLSSKEEDIIKPEQIIEQFDTVSYSKGASVLRMLSDFLTEPVFVQGLNTYLTMFADQNTVGE-- 485

  Fly   483 DLFASFQESADELGFTLPASVDDIFSSWSHQAGYPLLTVTRNYNAGTITITQKRYVAN------K 541
            ||:...|.:.::.|..||.||..|...|..|.|:|::||    |..|..::|..::.:      :
Zfish   486 DLWDHLQTAVNKTGTVLPLSVKVIMDRWVLQMGFPVVTV----NTTTGQVSQMHFLLDPESSLQR 546

  Fly   542 TDTNSATWYVPLNFATANKYDYRDTSATHYLLNVTETVISDVEASSDDWIIVNIQNSGYYRTLYD 606
            |...:..|.||:|:..:.....|     .:||..| .|.:|::.:..:|:::|:..:||||..||
Zfish   547 TSPFNYEWIVPINWMKSKMVQSR-----FWLLERT-AVYNDMKTTGSEWVLLNLNITGYYRVNYD 605

  Fly   607 TQNYGLITAALKSQPWRFHPRNRAQLLYDTYIFVSTDRLSHSILLELLGYLTNEQQYAPWSTANT 671
            ..|:..:...|..........||||::.|.:.......:..::.|:...||:.|::|.||.:|..
Zfish   606 IGNWERLLNQLAENHKVISVINRAQIVDDAFNLARAKIIPVTLALKTTTYLSEEREYMPWQSALN 670

  Fly   672 ILTVYDRYLRGDDSYYNFQDFVKRLIDPIFDKIGV-----NEIPGEHYLNNYLRIVLVSLACQVG 731
            .|..:.......:.|...|.:.|:.:.|:||....     :::|..| .:.|.::..:..||..|
Zfish   671 NLDYFYLMFTQTEVYRLLQSYTKKQVTPLFDYFKTITEDWSDVPSGH-TDQYNQVNAIRFACSTG 734

  Fly   732 SDDCYNQSANKLSEYL--YNGTAIEATLKTQAYCAGLRSTTNEIYSRVQSDLLSSSDSTDRSLFI 794
            .|:|.|.:::...:::  .|...|...|::..||:.:.:...|.:....:...:::...|:  .:
Zfish   735 VDECQNLTSSWYKQWMDQPNHNPIHPNLRSTVYCSAIATGGAEEWDFGWTMFKNAAIEADK--LM 797

  Fly   795 SSLGCSGSTSQLLDFLRLSLDTNNSLSYSERTSLLNSAYSRSEIGLTASLEFLESNWE-AYANLS 858
            |||.|:.:.:.|..:|..:||. :.:...:.||::....|..: |...:.||:.:.|| .:....
Zfish   798 SSLACAKNQTLLKRYLGYTLDP-SMIRKQDATSVIVYIASNPD-GQKLAWEFVRNKWEYMFTEYG 860

  Fly   859 DSAKPLDAALRGIATYVVSEKQKTRLNALVDVVEADGPSYINDDLSTTIDSRITSNFAWLEVNRD 923
            ..:....:.:.||.....:|.:..:|..........|.......|...|: :..:|..|:..|::
Zfish   861 VGSFNFASLISGITKTFSTEAELEQLLKFKSDNSEIGFGSATAALEQAIE-KTKANIKWVAENQE 924

  Fly   924 PVLNWI 929
            .:.:|:
Zfish   925 DITDWL 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31343	NP_732652.1	Peptidase_M1	57..446	CDD:279741	144/414 (35%)
		M1_APN_2	65..517	CDD:189008	168/479 (35%)
		ERAP1_C	591..886	CDD:288671	65/302 (22%)
LOC100004744	XP_001920418.2	Peptidase_M1	47..450	CDD:279741	144/415 (35%)
		M1_APN_2	57..520	CDD:189008	168/477 (35%)
		ERAP1_C	590..911	CDD:288671	68/326 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950