DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31272 and SV2A

DIOPT Version :9

Sequence 1:	NP_650013.3	Gene:	CG31272 / 326130	FlyBaseID:	FBgn0051272	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001315603.1	Gene:	SV2A / 9900	HGNCID:	20566	Length:	742	Species:	Homo sapiens

Alignment Length:	672	Identity:	149/672 - (22%)
Similarity:	259/672 - (38%)	Gaps:	162/672 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IPEKSKGLENDKDADGN-----SDSTAEAEATPTEEGSA-----------TFDKAIEGAGFGIFN 58
            ||....|.:.::.|||.     ....::.|..|...|.|           .::..:...|.|.|.
Human   101 IPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKEREELAQQYEAILRECGHGRFQ 165

  Fly    59 LMLLIV---SIPAQSAAIFESSSMSYILPIAECDLRLTLEDKGVLNAVAYAGMTISAIAWGYLAD 120
            ..|..|   ::.|....:|   .:.::||.||.|:.|:..:||:|..:.|.||.:.|..||.|||
Human   166 WTLYFVLGLALMADGVEVF---VVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLAD 227

  Fly   121 TKGRKKILYWGYLIDAVCVFGSALSQNFSMLVMFKFLGGLVVNGPAAVLFTYLTEMHGPKHRSSV 185
            ..||::.|.....:::|..|.|:..|.:...:..:.|.|:.:.|...::|:|.:|....:.|...
Human   228 RLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEH 292

  Fly   186 LMIVGMVTSTATVSLPLLAWGIFPR-DWDFEFW-GLQVHSWQIFLFVLGIPSLISGLIFCSMPES 248
            |..:.|......|....:||.|.|. .|.|:.. ..|.|||::|:.|...||:.:.....:.|||
Human   293 LSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPES 357

  Fly   249 PRFLMAQGRNEEALQAFKQIYHVNTR---KPKDSYP---IKALIQEVPNRKAAQNEVIYTIEEKS 307
            |||.:..|:::||....||::..|.|   .|:..:.   ||.:.||        :|:|
Human   358 PRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQE--------DELI------- 407

  Fly   308 GEVPTKRQSRTLAESLRAGLQQMKPLVRKPLLGLAICCY--------VMQFGIFLGMN----TIR 360
             |:    ||.|.....|.|::.:.  :...:.|..:.|:        :|..|::..|:    .:.
Human   408 -EI----QSDTGTWYQRWGVRALS--LGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLT 465

  Fly   361 LWLPQLFASM-----AEYEALHAGDGLD-VSMCTILEFSVNQTAE-----------TALNYADA- 407
            :|.|.:...:     |....:..|:.:: |:....||..:::..:           .::::.|:
Human   466 VWFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSL 530

  Fly   408 ---CSEPKVISMDMYLNN------------------------------------IIVSATG---F 430
               |....|.|.:.:..|                                    :.|:.||   :
Human   531 FEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAY 595

  Fly   431 VGYFFA---------GGILRALGPKRMMTYGLFLSGTFGLMLYFSVSSLMTLIVSATFLTITG-- 484
            :.||.:         |.|:.||           |....|.:...:.||:|: .||..||:...
Human   596 MVYFVSFLGTLAVLPGNIVSAL-----------LMDKIGRLRMLAGSSVMS-CVSCFFLSFGNSE 648

  Fly   485 ---IAVSSLLGAV------------VALFPTQLRTVVVAIAMMCGRFGALSGNLLFPVFVQTGCL 534
               ||:..|.|.|            |.|:|:..||..........:..|:.|..:|..||.....
Human   649 SAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKA 713

  Fly   535 PPFIMVSSVLILSGILSISLPD 556
            .|.:..|:.|.|...|::.||:
Human   714 APILFASAALALGSSLALKLPE 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31272	NP_650013.3	MFS	62..555	CDD:119392	133/601 (22%)
CG31272	NP_650013.3	2A0115	74..524	CDD:273327	123/555 (22%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	149/672 (22%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..144		10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8480
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870