DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31272 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_650013.3	Gene:	CG31272 / 326130	FlyBaseID:	FBgn0051272	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	469	Identity:	110/469 - (23%)
Similarity:	185/469 - (39%)	Gaps:	121/469 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 YAGMTISAIAWGYLADTKGRKKILYWGYLIDAVCVFGSALSQNFSMLVMFKFLGGL--VVNGPAA 167
            |.|:.:.:...|.|:|..|||.||:....:.....|....|.||.|..:...|.|:  :.|..||
Mouse   150 YVGVLLGSFISGQLSDRFGRKNILFLTMAMHTGFSFIQVFSVNFEMFTLLYTLVGMGHISNYVAA 214

  Fly   168 VLFTYLTEMHGPKHRSSVLMI-----VGMVTSTATVSLPLLAWGIFPRDWDFEFWGLQVHSWQIF 227
              |...|||..    .||.:|     |.:..:...:.|||.|:.|              ..|:..
Mouse   215 --FVLGTEMLS----KSVRIIFATLGVCIFFAFGFMVLPLFAYFI--------------REWRRL 259

  Fly   228 LFVLGIPSLISGLIFCSMPESPRFLMAQGRNEEALQAFKQIYHVNTRKPKDSYPIKALIQEVPNR 292
            |..:.:|.::.|.::..:|||||:|::|||.:||                          ||..|
Mouse   260 LLAITLPGVLCGALWWFIPESPRWLISQGRIKEA--------------------------EVIIR 298

  Fly   293 KAAQ-NEVI--YTIEEKSGEVPTKRQSRTLAESLRAGLQQMKPLVRKPLLGLAICCYVMQFGIFL 354
            |||: |.::  .||.:.|.....:..|....:|     ..:..|||.|.:.:            |
Mouse   299 KAAKINGIVAPSTIFDPSETNKLQDDSSKKPQS-----HHIYDLVRTPNIRI------------L 346

  Fly   355 GMNTIRLWLPQLFASMAEYEALHAGDGLDVSMCTILEFSVNQTAETALNYADACSEPKVISMDMY 419
            .:.:|.|||                        ||           ::.|.....:...::.::|
Mouse   347 TIMSIILWL------------------------TI-----------SVGYFGLSLDTPNLNGNIY 376

  Fly   420 LNNIIVSATGFVGYFFAGGILRALGPKRMMTYGLFLSGTFGLMLYFSVSSLMTLIVSATFLTITG 484
            :|..:::|.....|..|..:|:.:..:..|...|||.|:..|::....|.|..|  |.|.:.:..
Mouse   377 VNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYL--STTLVMVGK 439

  Fly   485 IAVSSLLGAV----VALFPTQLRTVVVAIAMMCGRFGALSGNLLFPVFVQTGCLP---PFIMVSS 542
            ..::|....|    ..|:||.:|.:.|.::....|.    |::|.|.||..|...   |:|::.|
Mouse   440 FGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRL----GSILSPYFVYLGAYDRRLPYILMGS 500

  Fly   543 VLILSGILSISLPD 556
            :.||:.|:::..|:
Mouse   501 LTILTAIITLFFPE 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31272	NP_650013.3	MFS	62..555	CDD:119392	109/466 (23%)
CG31272	NP_650013.3	2A0115	74..524	CDD:273327	98/432 (23%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	110/469 (23%)
		MFS	123..513	CDD:119392	109/466 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840