DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31272 and slc22a23

DIOPT Version :9

Sequence 1:	NP_650013.3	Gene:	CG31272 / 326130	FlyBaseID:	FBgn0051272	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_001338637.1	Gene:	slc22a23 / 555979	ZFINID:	ZDB-GENE-030131-3564	Length:	942	Species:	Danio rerio

Alignment Length:	540	Identity:	105/540 - (19%)
Similarity:	186/540 - (34%)	Gaps:	156/540 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LENDKDADGNSDSTAEAEATP-----TEEGSATFDKAIEGAGFGIFNLMLLIVS-IPAQSAAIF- 74
            |:.:..|..|...|.|...:|     |:.|...     ...|||.:...|:::: ||    |||
Zfish    11 LDTESHAPENGFVTPETSKSPGLLSQTDGGVLP-----SVGGFGKYQKQLIVLTWIP----AIFI 66

  Fly    75 --------------------ESSSMSYILPIA--------------ECD-------LRLTLEDKG 98
                                .||.:..:.|.|              :|:       |:..||...
Zfish    67 GFSQFSDNFLLTNPCPEPHNNSSQLLTVAPTAVSTVFTGVNTEAASQCNCTPSSYKLQNGLEQNI 131

  Fly    99 VL--NAVA-------------YAGMTISAIAWGYLADTKGRKKILYWGYLIDAVCVFGS--ALSQ 146
            |.  |.|.             ..|.....:..|.|||..||..:|....:.  :.|||.  |.|.
Zfish   132 VTKWNLVCDSAWKIHIAKFSLLVGSIFGYLVLGVLADWFGRHPVLILSVVF--LLVFGMTVAFSV 194

  Fly   147 NFSMLVMFKFLGGLVVNGPAAVLFTYLTEMHGPKHRSSVLMIVGMVTSTATVSLPLLAWGIFPRD 211
            |..|....:|..|..:.|....|:....|:..|..|.|:.|:...:.....:.:|.||  ...||
Zfish   195 NLPMFGTLRFFEGFCLAGITLSLYVLRIELCLPGWRFSITMVANFMMLAGQLLMPGLA--ALCRD 257

  Fly   212 WDFEFWGLQVHSWQIFLFVLGIPSLISGLIFCSMPESPRFLMAQGR------------------- 257
                        |||...|:..|.|:......:.|||.|:|:|..:
Zfish   258 ------------WQILQAVIVCPLLLMLSYIWAFPESLRWLLATQQYSRSKWIMERISKKNNINL 310

  Fly   258 NEEALQAFKQIYHVNTRKPKDSYPIKALIQEVPNRKAAQNEVIYTIEEKSGEVPTKRQSRTLAES 322
            .|:|.:...::.....::||.:    .:::.|..|...:|.|:..:...:|.......:|::.|.
Zfish   311 QEDAEELMTELNGALQKQPKKT----CIVKMVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMEK 371

  Fly   323 LRAG-LQQMKPLVRK----PLLGLAICCY-------------VMQFGIFLGM-NTIRLWLPQLFA 368
            ...| ::::.....:    .::.:|.|.:             ::.|.|...: :.::|.|..|..
Zfish   372 KTVGFVEKLHDFYAEYYVMAVIAVASCVFLCPAVALMGRRGGLLMFMIITALASLLQLGLLNLLG 436

  Fly   369 SMAEYEALHAGDGLD----VSMCTILEFSVNQTAETALNYADACSE--PKVISMDMYLNNIIVSA 427
            ...::.:|...|.|:    |:...|..||.:..:..::.:   |:|  |.||.....  .:::::
Zfish   437 KYGDHLSLVHSDELNDKFSVAFSIIGMFSSHAVSNLSIFF---CAEITPSVIRGGGL--GLVLAS 496

  Fly   428 TGF-------------VGYF 434
            .||             .|||
Zfish   497 AGFGMLTSPIMELHNQKGYF 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31272	NP_650013.3	MFS	62..555	CDD:119392	93/490 (19%)
CG31272	NP_650013.3	2A0115	74..524	CDD:273327	89/477 (19%)
slc22a23	NP_001338637.1	Sugar_tr	<131..547	CDD:331684	80/411 (19%)
slc22a23	NP_001338637.1	Atrophin-1	630..>937	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588494
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930