DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31272 and SVOP

DIOPT Version :9

Sequence 1:	NP_650013.3	Gene:	CG31272 / 326130	FlyBaseID:	FBgn0051272	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_061181.1	Gene:	SVOP / 55530	HGNCID:	25417	Length:	548	Species:	Homo sapiens

Alignment Length:	585	Identity:	126/585 - (21%)
Similarity:	218/585 - (37%)	Gaps:	143/585 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DKDADGNSDSTAEA-----EATPTEEGSA-----------TF--DKAIEGAGFGIFNLMLLIVSI 66
            |..|.|..:...|.     ||...::|:|           ||  :.|:|..|||.|...|.:::.
Human    27 DDTASGEHEVQIEGVHVGLEAVELDDGAAVPKEFANPTDDTFMVEDAVEAIGFGKFQWKLSVLTG 91

  Fly    67 PAQSAAIFESSSMSYILPIAECDLRLTLEDKGVLNAVAYAGMTISAIAWGYLADTKGRK---KI- 127
            .|..|...|...:|.:.|...|:.||......:|.:|.:.||..|:..||.::|..|||   ||
Human    92 LAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFVGMMSSSTLWGNISDQYGRKTGLKIS 156

  Fly   128 ----LYWGYLIDAVCVFGSALSQNFSMLVMFKFLGGLVVNG-PAAVLFTYLTEMHGPKHRSSVLM 187
                ||:|.|        ||.:..:|.:::.:.|.|..:.| |.:|  |...|....|.|:..::
Human   157 VLWTLYYGIL--------SAFAPVYSWILVLRGLVGFGIGGVPQSV--TLYAEFLPMKARAKCIL 211

  Fly   188 IVGMVTSTATVSLPLLAWGIFPRDWDFEFWGLQVHSWQIFLFVLGIPSLISGLIFCSMPESPRFL 252
            ::.:..:..||...:||..:.|.           ..|:..|.:..:|.|:..::...:|||.|:.
Human   212 LIEVFWAIGTVFEVVLAVFVMPS-----------LGWRWLLILSAVPLLLFAVLCFWLPESARYD 265

  Fly   253 MAQGRNEEALQAFKQIYHVNTRKPKDSYPIKALIQEVPNRKAAQN-------EVIYTIEEKSGEV 310
            :..|..|:|:...|:|                         |.:|       ::|.:.:|..|
Human   266 VLSGNQEKAIATLKRI-------------------------ATENGAPMPLGKLIISRQEDRG-- 303

  Fly   311 PTKRQSRTLAESLRAGLQQMKPLVRKPLLGLAICCYVMQFGIFLGMNTIRLWLPQLFASMAEY-- 373
                              :|:.|                |.......|:.||......:.:.|
Human   304 ------------------KMRDL----------------FTPHFRWTTLLLWFIWFSNAFSYYGL 334

  Fly   374 -----EALHAGDGLDVSMCTILEFSVNQTAETALNYADACSEPKVISMDMYLNNIIVSATGFVGY 433
                 |...|||     :|.|........|:.:|    ||   :.:|.:.|::.:..:.:.|.|.
Human   335 VLLTTELFQAGD-----VCGISSRKKAVEAKCSL----AC---EYLSEEDYMDLLWTTLSEFPGV 387

  Fly   434 FFAGGILRALGPKRMMTYGLFLSGTFGLMLYFSVS-SLMTLIVSATFLTITGIAVSSLLGAVV-- 495
            .....|:..||.|:.|.....:.....|:|:..|. :::||::......|:|    ....|.|
Human   388 LVTLWIIDRLGRKKTMALCFVIFSFCSLLLFICVGRNVLTLLLFIARAFISG----GFQAAYVYT 448

  Fly   496 -ALFPTQLRTVVVAIAMMCGRFGALSGNLLFPVFVQTGCLPPFIMVSSVLILSGILSISLPDPAK 559
             .::||..|.:.:.......|.|||....:..|.:::.......:.|...:|:.:.|..||...|
Human   449 PEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETK 513

Fly 560 559
Human 514 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31272	NP_650013.3	MFS	62..555	CDD:119392	106/519 (20%)
CG31272	NP_650013.3	2A0115	74..524	CDD:273327	100/476 (21%)
SVOP	NP_061181.1	MFS_SVOP	87..509	CDD:340999	106/519 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010