DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31272 and SV2C

DIOPT Version :9

Sequence 1:	NP_650013.3	Gene:	CG31272 / 326130	FlyBaseID:	FBgn0051272	Length:	563	Species:	Drosophila melanogaster
Sequence 2:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens

Alignment Length:	625	Identity:	150/625 - (24%)
Similarity:	240/625 - (38%)	Gaps:	112/625 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LENDKDADGNSDSTAEAEATPTEEGSATFDKAIEGAGFGIFNLMLLIVSIPAQSAAIFESSSMSY 81
            ||:::.||             .||.:..::..|:..|.|.|...|..|...|..|...|...:.:
Human   123 LESERRAD-------------EEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGF 174

  Fly    82 ILPIAECDLRLTLEDKGVLNAVAYAGMTISAIAWGYLADTKGRKKILYWGYLIDAVCVFGSALSQ 146
            :||.||.||.:.....|.|.::.|.||.:.|..||.|||..|||:.|.....::....|.|:..|
Human   175 VLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQ 239

  Fly   147 NFSMLVMFKFLGGLVVNGPAAVLFTYLTEMHGPKHRSSVLMIVGMVTSTATVSLPLLAWGIFPR- 210
            .:...:..:.|.|..:.|....:|:|..|:...:.|...|..:.|......:....:||.|.|.
Human   240 GYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHY 304

  Fly   211 DWDFEFW-GLQVHSWQIFLFVLGIPSLISGLIFCSMPESPRFLMAQGRNEEALQAFKQIYHVNTR 274
            .|.|... ..|.|||::|:.|..:|.:.|.:....||||||||:..|:::||....|.|:..|.|
Human   305 GWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMR 369

  Fly   275 ---KPKDSYPIKALIQEVPNRKAAQNEVIYTIEEKSGEVPTKRQSRTLAESLRAGLQQMKPL--- 333
               :|:..:.:..:      :...|.:.:..||..:|....:...|...|.....|..|:..
Human   370 ARGQPEKVFTVNKI------KTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYP 428

  Fly   334 VRKPLLGLAICCYVMQFGIFLGMNTIRLWLPQLFASMA--EYEALHAGDGLDVSMCTILEFSVNQ 396
            ||...:.|.|..:.:.|| :.|::   :|.|.:...:.  ||..|..    :|.......|::|.
Human   429 VRDNTIKLTIVWFTLSFG-YYGLS---VWFPDVIKPLQSDEYALLTR----NVERDKYANFTINF 485

  Fly   397 TAE----TALNYAD-------------------ACSEPKVISMDMYLNN-----IIVSATGFVGY 433
            |.|    |.:.|.:                   :|:...|.|::.|..|     .:...|.|..|
Human   486 TMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPY 550

  Fly   434 FF------------------------------------------AGGILRAL-----GPKRMMTY 451
            .|                                          .|.|:.||     |...|:..
Human   551 KFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGG 615

  Fly   452 GLFLSGTFGLMLYFSVSSLMTLIVSATFLTITGIAVSSLLGAVVALFPTQLRTVVVAIAMMCGRF 516
            .:.|||.....|:|..|..|.:.:...:..:|..|.:||....|.|:||..|...........:.
Human   616 SMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKA 680

  Fly   517 GALSGNLLFPVFVQTGCLPPFIMVSSVLILSGILSISLPD 556
            .|:.|||:|...|......|.::.|:||:..|::.:.|||
Human   681 AAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPD 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31272	NP_650013.3	MFS	62..555	CDD:119392	136/577 (24%)
CG31272	NP_650013.3	2A0115	74..524	CDD:273327	125/534 (23%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	150/625 (24%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		2/4 (50%)
		MFS	155..719	CDD:119392	136/577 (24%)
		Pentapeptide_3	507..561	CDD:290309	9/53 (17%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		9/43 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D724235at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8480
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920