DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and Zfp423

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	XP_011246862.1	Gene:	Zfp423 / 94187	MGIID:	1891217	Length:	1312	Species:	Mus musculus

Alignment Length:	1448	Identity:	259/1448 - (17%)
Similarity:	446/1448 - (30%)	Gaps:	495/1448 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 DSKVASCRACSLQFSTRANARRHERNLHP----NLFQLS--TDSPHNTPITKPTPALAAALEMQR 636
            |..:.:|..|...|.:.|:...|..:..|    :..|||  ..||.:..:..||..:....::
Mouse    91 DESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIGDGCDL-- 153

  Fly   637 AAAAAATAEANRAAGAAGGNISTQKYRQVVMNAFIKCEGGGYDYDNPEQYRPLLTRDKVEFIEQN 701
                        ..|...|........|....:||                      ::.:::::
Mouse   154 ------------GLGEEEGGTGLPYPCQFCDKSFI----------------------RLSYLKRH 184

  Fly   702 DEFLEQYQTMTCRCCNKYFSTYKNFMAHVR-----KKYPQLPRNLCFNCLKMNDSKALF--ISHL 759
            ::.........|..|::.|...::...|::     |||.      |..|      :|.|  ..||
Mouse   185 EQIHSDKLPFKCTFCSRLFKHKRSRDRHIKLHTGDKKYH------CHEC------EAAFSRSDHL 237

  Fly   760 KKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGEVVTP 824
            |    |:|         ||.:
Mouse   238 K----IHL---------KTHS-------------------------------------------- 245

  Fly   825 GGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVY-----DKHADVQRKD--NNSIQCS 882
               |.:|             ::|.:|.:||.:....::|:.     .:|.....|:  .:...|.
Mouse   246 ---SSKP-------------FKCSVCKRGFSSTSSLQSHMQAHKKNKEHLAKSEKEAKKDDFMCD 294

  Fly   883 FCGLDFADPVDRRRH----YNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNA 943
            :|...|:...:..:|    :..:.....|:|:.|..........|.|::|.|........:....
Mouse   295 YCEDTFSQTEELEKHVLTLHPQLSEKADLQCIHCPEVFVDESTLLAHIHQAHANQKHKCPMCPEQ 359

  Fly   944 STTGSGM-------ARSNSMEHSPGKRSLLGALGVGSSAEESRSSS----AAPPLTSTPKLAGGN 997
            .::..|:       .:.:|..||.....:||::...|||....|:|    :.|..|..| |.|..
Mouse   360 FSSVEGVYCHLDSHRQPDSSNHSVSPDPVLGSVASMSSATPDSSASVERGSTPDSTLKP-LRGQK 423

  Fly   998 QVGGGGSTSASAAAAAQSSANRD---------------ASAPKSQY-----FSRMPQV------- 1035
            ::...|.:......:....:.||               |..|:..:     ...||.:
Mouse   424 KMRDDGQSWPKVVYSCPYCSKRDFTSLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHV 488

  Fly  1036 ---------------------CPICGQQYNNYNNVLRHMESKH--PNKLP----ETYKCVRCGLG 1073
                                 |..|.:.:.:.|::..|:...|  ||..|    ..:.|.:|.:|
Mouse   489 RKLHKSHAYPVMQFGNISAFHCNYCPEMFADINSLQEHIRVSHCGPNANPPDGNNAFFCNQCSMG 553

  Fly  1074 YPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGT 1138
            :...|.|.||:...|                     .:.|||                      .
Mouse   554 FLTESSLTEHIQQAH---------------------CSVGST----------------------K 575

  Fly  1139 LDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPIC--NAVFSNNIGLSNHMRSHYTASNAV 1201
            |:....:|              ..|.:.|.|    ||.|  :.:|.:.:.|:.|::     .|..
Mouse   576 LESPVVQP--------------TQSFMEVYS----CPYCTNSPIFGSILKLTKHIK-----ENHK 617

  Fly  1202 NAALAAANR----MTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRR 1262
            |..||.:.:    .:|.|..:..:......|. |...|.|....|.|    ..:........|:.
Mouse   618 NIPLAHSKKSKAEQSPVSSDVEVSSPKRQRLS-GSANSISNGEYPCN----QCDLKFSNFESFQT 677

  Fly  1263 SLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFK 1327
            .|....:...|:..|..|:..|.|::|...|:...:...:..:: |:.|:.:|:....|:.||..
Mouse   678 HLKLHLELLLRKQACPQCKEDFDSQESLLQHLTVHYMTTSTHYV-CESCDKQFSSVDDLQKHLLD 741

  Fly  1328 VHGKAIKDEMIIKQFECDVCSIVYSSESELQQH-------KRSVHKLTSASASTSASTSSKIDDD 1385
            :|...:        :.|.:|..|:.|:..:|.|       ::.:::.|:.:
Mouse   742 MHTFVL--------YHCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACN-------------- 784

  Fly  1386 SLMDDGKPTSSDLADLSTLAAG---GSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSND 1447
              .|..|.     |||......   |:.|.|    ::|.:|...|:|..:|..||.:|    |..
Mouse   785 --WDFRKE-----ADLQVHVKHSHLGNPAKA----HKCIFCGETFSTEVELQCHITTH----SKK 834

  Fly  1448 YSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTPTCNRKPITSTGAHQ 1512
            |:|:.|...:.....|..|..:||           |   .||....:.   |.|..|.|||...:
Mouse   835 YNCRFCSKAFHAVILLEKHLREKH-----------C---VFDAAAENG---TANGVPPTSTKKAE 882

  Fly  1513 QQD--GQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSL 1575
            ..|  |.|..:..|..:   |:..:||.:..:
Mouse   883 PADLQGMLLKNPEAPNS---HEASEDDVDASE--------------------------------- 911

  Fly  1576 KIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYA 1640
                |...|.||||.:|.:.....|..:       |:.:....|||.....:|      ..|.:.
Mouse   912 ----PMYGCDICGAAYTMEVLLQNHRLR-------DHNIRPGEDDGSRKKAEF------IKGSHK 959

  Fly  1641 CDLCAKTFPQVIALKVHRKWHFRGDSKQN--PIDGE--ATQLTNNNHTTNNNNNNSMHLRELHA- 1700
            |::|::||.....|:.|.:.| ||.:|..  ||.||  .:.||...|...       |.:.|..
Mouse   960 CNVCSRTFFSENGLREHLQTH-RGPAKHYMCPICGERFPSLLTLTEHKVT-------HSKSLDTG 1016

  Fly  1701 ---VGLMPNQQQQSLNNSCNSSMNHNNN--------------------------------SSSNR 1730
               :..||.|.::.....|....:..|:                                ||:..
Mouse  1017 TCRICKMPLQSEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAAS 1081

  Fly  1731 SKSMKRKREL-KCEYCASTFISNNNLRR-------------HMYELHKHEVSNL--PEPPVIVVD 1779
            |.:.:..::| ||..|...|.|..:|.|             .|......:|..|  |||.
Mouse  1082 SPNGQGLQKLYKCALCLKEFRSKQDLVRLDVNGLPYGLCAGCMARSANGQVGGLAPPEPA----- 1141

  Fly  1780 DH----LTCRRCQLKFDTKELWIEHKLADAKVVRP----------FCPF----QWGCDLCGEYLS 1826
            |.    |.|..|.:||::.|....|...|.:.:.|          ..|.    .:.|..|.....
Mouse  1142 DRPCAGLRCPECNVKFESAEDLESHMQVDHRDLTPETSGPRKGAQTSPVPRKKTYQCIKCQMTFE 1206

  Fly  1827 RKEKLMNHINNHLKEEVI 1844
            .:.::..|:.||:.||.|
Mouse  1207 NEREIQIHVANHMIEEGI 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1067..1088	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1279..1298	CDD:275371	5/18 (28%)
		C2H2 Zn finger	1308..1325	CDD:275371	4/16 (25%)
		C2H2 Zn finger	1420..1440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1450..1468	CDD:275368	4/17 (24%)
Zfp423	XP_011246862.1	C2H2 Zn finger	168..188	CDD:275368	3/41 (7%)
		C2H2 Zn finger	196..216	CDD:275368	4/19 (21%)
		COG5048	222..623	CDD:227381	88/552 (16%)
		C2H2 Zn finger	224..244	CDD:275368	10/38 (26%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		C2H2 Zn finger	293..312	CDD:275368	4/18 (22%)
		C2H2 Zn finger	439..460	CDD:275368	2/20 (10%)
		C2H2 Zn finger	471..495	CDD:275368	2/23 (9%)
		C2H2 Zn finger	510..529	CDD:275368	4/18 (22%)
		C2H2 Zn finger	692..712	CDD:275368	6/19 (32%)
		C2H2 Zn finger	722..743	CDD:275368	6/20 (30%)
		C2H2 Zn finger	750..771	CDD:275368	6/20 (30%)
		C2H2 Zn finger	780..801	CDD:275368	6/41 (15%)
		C2H2 Zn finger	811..831	CDD:275368	7/19 (37%)
		C2H2 Zn finger	837..855	CDD:275368	4/17 (24%)
		C2H2 Zn finger	916..937	CDD:275368	7/27 (26%)
		C2H2 Zn finger	960..980	CDD:275368	6/19 (32%)
		C2H2 Zn finger	989..1009	CDD:275368	7/26 (27%)
		C2H2 Zn finger	1228..1248	CDD:275368
		C2H2 Zn finger	1259..1280	CDD:275368
		C2H2 Zn finger	1289..1305	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100