DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and ZNF208

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	1253	Identity:	226/1253 - (18%)
Similarity:	372/1253 - (29%)	Gaps:	426/1253 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   685 QYRPLLTRDKVEFIEQNDEFLEQYQTMT-------------CRCCNKYFSTY----KNFMAHV-R 731
            |::.:.||:.....|:..:......|:|             |:.|.|.||.:    |:.:.|. .
Human   190 QHKRIYTRENSYKCEEGGKAFNWSSTLTYYKSAHTGEKPYRCKECGKAFSKFSILTKHKVIHTGE 254

  Fly   732 KKYPQLPRNLCFNCLKMNDSKALFISHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATG 796
            |.|.      |..|.|..:..|:...|          ::::                      ||
Human   255 KSYK------CEECGKAFNQSAILTKH----------KIIH----------------------TG 281

  Fly   797 SIPVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKL--------RAKELLVNKL-------YE 846
            ..|......|.......|:|....:    ...|:|.|.        :...|:.:|.       |:
Human   282 EKPNKCEECGKAFSKVSTLTTHKAI----HAGEKPYKCKECGKAFSKVSTLITHKAIHAGEKPYK 342

  Fly   847 CKLCPKGFR-----TKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVR 906
            ||.|.|.|.     |||:. .|..:|          ..:|..||..:..|
Human   343 CKECGKAFSKFSILTKHKV-IHTGEK----------PYKCEECGKAYKWP--------------- 381

  Fly   907 LRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGMARSNSMEHSPGKRSLLGALGV 971
                   :.|..|::.       |.|                         ..|.|
Human   382 -------STLSYHKKI-------HTG-------------------------EKPYK--------- 398

  Fly   972 GSSAEE-SRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQV 1035
               .|| .:..|....||....:..|.:                                  |..
Human   399 ---CEECGKGFSMFSILTKHEVIHTGEK----------------------------------PYK 426

  Fly  1036 CPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHG--------VDK 1092
            |..||:.:|..:|::.| :..|..:.|  |||..||.|:...|.|.:|.:..:|        .||
Human   427 CEECGKAFNWSSNLMEH-KKIHTGETP--YKCEECGKGFSMFSILTKHKVIHNGEKPYKCEECDK 488

  Fly  1093 NRHSGGFEYIVNADAVKLADGST-----PNVYTGRYDYVMKD------LMSITNGGTLDDEEEEP 1146
            ..|:|...|... :..|..:.|:     ..::||...|..::      ..||.....:....|:|
Human   489 ATHAGEKPYKCE-ECGKAFNWSSNLMEHKRIHTGEKPYKCEECGKSFSTFSILTKHKVIHTGEKP 552

  Fly  1147 ---GSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSH-----YTASNAVNA 1203
               ....|..:...:.:....:....:..:|..|...|:.:..|..|.|.|     |........
Human   553 YKCEECGKAYKWSSTLSYHKKIHTVEKPYKCEECGKAFNQSAILIKHKRIHTGEKPYKCEECGKT 617

  Fly  1204 ALAAANRMTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAA 1268
            ....:...|.|::.....|....|  .|.|..:.:..|             ..:|:      .|.
Human   618 FSKVSTLTTHKAIHAGEKPYKCKE--CGKTFIKVSTLT-------------THKAI------HAG 661

  Fly  1269 DRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNV--QFIKCKLCNAEFAYEKGLKVHLFKVH-- 1329
            ::.:   :|:.|.:.||     ::.:||.|:|.:.  :..||:.|...|.:...|..|. ::|
Human   662 EKPY---KCKECGKAFS-----KFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEHK-RIHTG 717

  Fly  1330 ---------GKAIKDEMII----------KQFECDVCSIVYSSESELQQHKRSVHKLTSASASTS 1375
                     ||:.....::          |.::|:.|...|...|.|..||: :|
Human   718 EKPYKCEECGKSFSTFSVLTKHKVIHTGEKPYKCEECGKAYKWSSTLSYHKK-IH---------- 771

  Fly  1376 ASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSH 1440
                                              |...|   |:|:.|...||.:..|..|...|
Human   772 ----------------------------------TVEKP---YKCEECGKAFNRSAILIKHKRIH 799

  Fly  1441 DEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTPTCNRKPI 1505
            .  |...|.|::||..:|...:|..|  |.......|.:|..|.|.|....:...|       .:
Human   800 T--DEKPYKCEECGKTFSKVSTLTTH--KAIHAGEKPYKCKECGKAFSKFSILTKH-------KV 853

  Fly  1506 TSTGAHQQQDGQLHSHHTAKRTIFRHK---TGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGS 1567
            ..||....:..:....:....|:..||   ||        ::..:.||    .|.|.::......
Human   854 IHTGEKPYKCEECGKAYKWPSTLSYHKKIHTG--------EKPYKCEE----CGKGFSMFSILTK 906

  Fly  1568 TAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVER 1632
            .....|..|    ...|..||..|:....||||.:.|..|.:
Human   907 HEVIHTGEK----PYKCEECGKAFSWLSVFSKHKKTHAGEKF----------------------- 944

  Fly  1633 QNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRE 1697
                  |.|:.|.|.:.....|..|:|.|    :::.|...|..          ....::..:..
Human   945 ------YKCEACGKAYKSSSTLSYHKKIH----TEEKPYKYEEC----------GKGFSTFSILT 989

  Fly  1698 LHAV---GLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRRHM 1759
            .|.|   |..|.:.::     |..:.|.::|...:: |....:...|||.|...|...::|.
Human   990 KHKVIHTGEKPYKCEE-----CGKAFNWSSNLMEHK-KIHTGETPYKCEECDKAFSWPSSLT--- 1045

  Fly  1760 YELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEY 1824
                :|:.::..|.|       ..|..|...|.......|||...|...    |::  |:.||:.
Human  1046 ----EHKATHAGEKP-------YKCEECGKAFSWPSRLTEHKATHAGEE----PYK--CEECGKA 1093

  Fly  1825 LSRKEKLMNHINNHLKEE 1842
            .:....||.|...|..|:
Human  1094 FNWSSNLMEHKRIHTGEK 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1067..1088	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1279..1298	CDD:275371	5/18 (28%)
		C2H2 Zn finger	1308..1325	CDD:275371	4/16 (25%)
		C2H2 Zn finger	1420..1440	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1450..1468	CDD:275368	6/17 (35%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368	1/4 (25%)
		C2H2 Zn finger	203..223	CDD:275368	3/19 (16%)
		COG5048	227..619	CDD:227381	94/548 (17%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	5/29 (17%)
		C2H2 Zn finger	287..307	CDD:275368	3/23 (13%)
		C2H2 Zn finger	315..335	CDD:275368	2/19 (11%)
		C2H2 Zn finger	343..363	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..391	CDD:275368	6/48 (13%)
		zf-H2C2_2	384..407	CDD:290200	8/66 (12%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368	6/20 (30%)
		zf-H2C2_2	439..463	CDD:290200	10/26 (38%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	499..519	CDD:275368	2/20 (10%)
		zf-H2C2_2	511..536	CDD:290200	3/24 (13%)
		C2H2 Zn finger	527..547	CDD:275368	2/19 (11%)
		C2H2 Zn finger	555..575	CDD:275368	1/19 (5%)
		zf-H2C2_2	568..592	CDD:290200	3/23 (13%)
		C2H2 Zn finger	583..603	CDD:275368	6/19 (32%)
		zf-H2C2_2	596..619	CDD:290200	5/22 (23%)
		C2H2 Zn finger	611..631	CDD:275368	2/19 (11%)
		C2H2 Zn finger	639..659	CDD:275368	5/40 (13%)
		C2H2 Zn finger	667..687	CDD:275368	8/24 (33%)
		COG5048	691..1133	CDD:227381	109/566 (19%)
		C2H2 Zn finger	695..715	CDD:275368	5/20 (25%)
		zf-H2C2_2	707..732	CDD:290200	5/25 (20%)
		C2H2 Zn finger	723..743	CDD:275368	2/19 (11%)
		C2H2 Zn finger	751..771	CDD:275368	7/20 (35%)
		zf-H2C2_2	764..788	CDD:290200	10/71 (14%)
		C2H2 Zn finger	779..799	CDD:275368	6/19 (32%)
		C2H2 Zn finger	807..827	CDD:275368	7/21 (33%)
		C2H2 Zn finger	835..855	CDD:275368	5/26 (19%)
		C2H2 Zn finger	863..883	CDD:275368	3/19 (16%)
		zf-H2C2_2	876..899	CDD:290200	8/34 (24%)
		C2H2 Zn finger	891..911	CDD:275368	4/23 (17%)
		C2H2 Zn finger	919..939	CDD:275368	8/19 (42%)
		C2H2 Zn finger	947..967	CDD:275368	6/19 (32%)
		C2H2 Zn finger	976..995	CDD:275368	3/28 (11%)
		C2H2 Zn finger	1003..1023	CDD:275368	4/25 (16%)
		zf-H2C2_2	1015..1039	CDD:290200	6/24 (25%)
		C2H2 Zn finger	1031..1051	CDD:275368	6/26 (23%)
		C2H2 Zn finger	1059..1079	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1087..1107	CDD:275368	6/19 (32%)
		zf-H2C2_2	1099..1124	CDD:290200	5/13 (38%)
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930