DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and ZNF99

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	1318	Identity:	218/1318 - (16%)
Similarity:	359/1318 - (27%)	Gaps:	595/1318 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 CSLQFSTRANARRHERNLHPNLFQLSTDSPHNTPITKPTPALAAALEMQRAAAAAATAEANRAAG 651
            |..|.....|.:|||....|.:.     |.|.|....|..::
Human    55 CLKQGKEPWNMKRHEMVTKPPVI-----SSHFTQDFWPDQSI----------------------- 91

  Fly   652 AAGGNISTQKYRQVVMNAFIKCEGGGYDYDNPEQYRPLLTRDKVEFIEQNDEFLEQYQTMTCRC- 715
                   ...::::::..:.:|           .::.|..|...|.:.:.....|.|..:. :|
Human    92 -------KDSFQEIILRTYARC-----------GHKNLRLRKDCESVNEGKMHEEAYNKLN-QCW 137

  Fly   716 ---------CNKY---FSTYKNF----MAHVRKKYPQLPRNLCFNCLKMNDSKALF-ISHLKKRN 763
                     ||||   |..|.|.    :.|.:||        .|.|:|.  ||:.| :|||.:..
Human   138 TTTQGKIFQCNKYVKVFHKYSNSNRYKIRHTKKK--------TFKCMKC--SKSFFMLSHLIQHK 192

  Fly   764 CI----NLFRVLNALRGKT----TTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGE 820
            .|    |:::...  |||.    :|::
Human   193 RIHTRENIYKCEE--RGKAFKWFSTLI-------------------------------------- 217

  Fly   821 VVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCG 885
                      ..|:...|   :|.|:.|.|.|.|.....|                  .:|...
Human   218 ----------KHKIIHTE---DKPYKYKKCGKAFNISSMF------------------TKCKII- 250

  Fly   886 LDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGM 950
                       |.....|    :|..|                        |.|.:|:||.
Human   251 -----------HTGKKPC----KCEEC------------------------GKVFNNSSTL---- 272

  Fly   951 ARSNSMEHS---PGKRSLLGALGVGSSAEESRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAA 1012
                 |:|.   .||:..        ..||                              ...|.
Human   273 -----MKHKIIHTGKKPY--------KCEE------------------------------CGKAF 294

  Fly  1013 AQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRI 1077
            .|||   ..:..|:.:....|..|..||:.:|:::.:.:| :..|..|.|  |||..||..:.:.
Human   295 KQSS---HLTRHKAIHTGEKPYKCEECGKAFNHFSALRKH-QIIHTGKKP--YKCEECGKAFSQS 353

  Fly  1078 SYLREHMINVHGVDKNRHSGGFEY------IVNADAVKLADGSTPNVYTGRYDY-------VMKD 1129
            |.||:|.| :|..:|     .::|      ..|..|::..:    .::||:..|       ..|.
Human   354 STLRKHEI-IHTEEK-----PYKYEECGKAFSNLSALRKHE----IIHTGQKPYKCEECGKAFKW 408

  Fly  1130 LMSITNGGTLDDEE-----EEPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSN 1189
            ...:|....:...|     ||.|...|:.   .:.....::....|..:|..|:..|||...|..
Human   409 SSKLTVHKVIHTAEKPCKCEECGKAFKRF---SALRKHKIIHTGKQPYKCEECSKAFSNFSALRK 470

  Fly  1190 HMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTP 1254
            |...|                                                       ..:.|
Human   471 HEIIH-------------------------------------------------------TGEKP 480

  Fly  1255 QEQAVFRRSLDQAADRRFRRMRCRICQRRF--SSKKSYRYHMLTDHQVQNVQF--IKCKLCNAEF 1315
                                .:|..|.:.|  |||       ||.|:|.:::.  .||:.|...|
Human   481 --------------------YKCEECGKAFKWSSK-------LTVHKVIHMEEKPCKCEECGKAF 518

  Fly  1316 AYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSS 1380
            .:...|:.|.....||        |.::|:.|...:::.|.|.:|| .:|
Human   519 KHFSALRKHKIIHTGK--------KPYKCEECGKAFNNSSTLMKHK-IIH--------------- 559

  Fly  1381 KIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDS 1445
                                         |...|   |:|:.|...|    |.:.|:..|....:
Human   560 -----------------------------TGKKP---YKCEECGKAF----KQSSHLTRHKAIHT 588

  Fly  1446 ND--YSCKDCGNVYSG----RKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTPTCNRKP 1504
            .:  |.|::||..::.    ||...:|..||      |.:|..|.|.|
Human   589 GEKPYKCEECGKAFNHFSALRKHQIIHTGKK------PYKCEECGKAF----------------- 630

  Fly  1505 ITSTGAHQQQDGQLHSH---HTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASG 1566
                    .|...|..|   ||.::
Human   631 --------SQSSTLRKHEIIHTGEK---------------------------------------- 647

  Fly  1567 STAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVE 1631
                          ...|..||..|....|.::|...|.:|    .|
Human   648 --------------PYKCEECGKAFKWSSHLTRHKVIHTEE----KP------------------ 676

  Fly  1632 RQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNPID----GEATQLTNNNHTTNNNNNNS 1692
                   |.|:.|.|.|....||:.|:..|    :.:.|..    |:|.           :.:::
Human   677 -------YKCEECGKAFNHFSALRKHKIIH----TGKKPYKCEECGKAF-----------SQSST 719

  Fly  1693 MHLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRR 1757
            :...|:...|..|.:.::     |..:...::..:.::......| ..|||.|...|       :
Human   720 LRKHEIIHTGEKPYKCEE-----CGKAFKWSSKLTVHKVIHTAEK-PCKCEECGKAF-------K 771

  Fly  1758 HMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCG 1822
            |...|.||::.:..:.|       ..|..|...|:......:|::....      ...:.|:.||
Human   772 HFSALRKHKIIHTGKKP-------YKCEECGKAFNNSSTLRKHEIIHTG------EKSYKCEECG 823

  Fly  1823 EYLSRKEKLMNHINNHLK 1840
            :......||..|...|::
Human   824 KAFQWSSKLTLHKVIHME 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1067..1088	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1279..1298	CDD:275371	7/20 (35%)
		C2H2 Zn finger	1308..1325	CDD:275371	4/16 (25%)
		C2H2 Zn finger	1420..1440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1450..1468	CDD:275368	6/21 (29%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630	2/8 (25%)
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368	7/19 (37%)
		C2H2 Zn finger	175..195	CDD:275368	8/21 (38%)
		C2H2 Zn finger	203..223	CDD:275368	5/69 (7%)
		C2H2 Zn finger	232..251	CDD:275368	6/48 (13%)
		C2H2 Zn finger	259..279	CDD:275368	9/52 (17%)
		COG5048	267..684	CDD:227381	124/738 (17%)
		zf-H2C2_2	272..296	CDD:290200	7/70 (10%)
		C2H2 Zn finger	287..307	CDD:275368	7/52 (13%)
		zf-H2C2_2	299..324	CDD:290200	5/24 (21%)
		C2H2 Zn finger	315..335	CDD:275368	5/20 (25%)
		zf-H2C2_2	327..352	CDD:290200	9/27 (33%)
		C2H2 Zn finger	343..363	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..391	CDD:275368	3/23 (13%)
		zf-H2C2_2	383..407	CDD:290200	4/27 (15%)
		C2H2 Zn finger	399..419	CDD:275368	2/19 (11%)
		C2H2 Zn finger	427..447	CDD:275368	4/22 (18%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		zf-H2C2_2	467..491	CDD:290200	6/98 (6%)
		C2H2 Zn finger	483..503	CDD:275368	10/26 (38%)
		C2H2 Zn finger	511..531	CDD:275368	5/19 (26%)
		zf-H2C2_2	523..548	CDD:290200	7/32 (22%)
		COG5048	534..857	CDD:227381	84/523 (16%)
		C2H2 Zn finger	539..559	CDD:275368	6/20 (30%)
		zf-H2C2_2	552..576	CDD:290200	10/75 (13%)
		C2H2 Zn finger	567..587	CDD:275368	6/23 (26%)
		zf-H2C2_2	579..604	CDD:290200	6/24 (25%)
		C2H2 Zn finger	595..615	CDD:275368	5/19 (26%)
		zf-H2C2_2	607..632	CDD:290200	10/55 (18%)
		C2H2 Zn finger	623..643	CDD:275368	7/44 (16%)
		zf-H2C2_2	636..659	CDD:290200	7/76 (9%)
		C2H2 Zn finger	651..671	CDD:275368	6/19 (32%)
		zf-H2C2_2	663..688	CDD:290200	10/53 (19%)
		C2H2 Zn finger	679..699	CDD:275368	7/19 (37%)
		zf-H2C2_2	691..716	CDD:290200	7/39 (18%)
		C2H2 Zn finger	707..727	CDD:275368	3/30 (10%)
		zf-H2C2_2	720..743	CDD:290200	4/27 (15%)
		C2H2 Zn finger	735..755	CDD:275368	1/24 (4%)
		C2H2 Zn finger	763..783	CDD:275368	8/26 (31%)
		zf-H2C2_2	775..800	CDD:290200	7/31 (23%)
		C2H2 Zn finger	791..811	CDD:275368	4/19 (21%)
		C2H2 Zn finger	819..839	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930