DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and ZFY

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001356631.1	Gene:	ZFY / 7544	HGNCID:	12870	Length:	801	Species:	Homo sapiens

Alignment Length:	910	Identity:	179/910 - (19%)
Similarity:	271/910 - (29%)	Gaps:	295/910 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   778 TTTVVVP---IADDVADDGATG-------------SIPVADAGAGVVAMNSPTVTASGEVVTPGG 826
            |..|.:|   :.|||.....|.             |:.|.|.|.....::...|.|  |::|...
Human   105 TEEVSLPHCTVPDDVLASDITSTSMSMPEHVLTSESMHVCDIGHVEHMVHDSVVEA--EIITDPL 167

  Fly   827 GSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHA-DVQRKDNNSIQCS---FCGLD 887
            .|:    :.::|:||   .:|  .|:.          |.|... .|.::||:...|.   ...||
Human   168 TSD----IVSEEVLV---ADC--APEA----------VIDASGISVDQQDNDKASCEDYLMISLD 213

  Fly   888 FADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLD-------HVY-------QDHLGGVGGGA 938
            .|..::   |..:..       :|.||:.|.....:|       .||       :|.|||.....
Human   214 DAGKIE---HDGSTG-------VTIDAESEMDPCKVDSTCPEVIKVYIFKADPGEDDLGGTVDIV 268

  Fly   939 VSDNASTTGSGMARSNSMEHSPGKRSLLGALGVGSSAEESRSSSAAPPLTSTPKLAGG---NQVG 1000
            .|:..:..|..:...||....|  |..:..:.|..|.:|....:.|       ::|..   ..:.
Human   269 ESEPENDHGVELLDQNSSIRVP--REKMVYMTVNDSQQEDEDLNVA-------EIADEVYMEVIV 324

  Fly  1001 GGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPIC-GQQYNNYN----------NVLRHME 1054
            |....:.:|||||......|.        ..|....||. ...|.|.:          :.|.|::
Human   325 GEEDAAVAAAAAAVHEQQIDE--------DEMKTFVPIAWAAAYGNNSDGIENRNGTASALLHID 381

  Fly  1055 ---------SKHPNK--LPET------------------YKCVRCGLGYPRISYLREHMIN--VH 1088
                     .:.|.|  .|::                  |.|:.||..:....:|:.||.|  .|
Human   382 ESAGLGRLAKQKPKKKRRPDSRQYQTAIIIGPDGHPLTVYPCMICGKKFKSRGFLKRHMKNHPEH 446

  Fly  1089 GVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKM 1153
            ...|..|....:|..|                                              ||:
Human   447 LAKKKYHCTDCDYTTN----------------------------------------------KKI 465

  Fly  1154 RLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTI 1218
            .|.:...:..|...|.:..||..|...||:...|..|...|..         ..||:|.......
Human   466 SLHNHLESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKE---------KGANKMHKCKFCE 521

  Fly  1219 TATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRR 1283
            ..|                                 .||.:..|.|.....:.|..: |..|.:.
Human   522 YET---------------------------------AEQGLLNRHLLAVHSKNFPHI-CVECGKG 552

  Fly  1284 FSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCS 1348
            |......|.||......:..|   |:.|....|....||.|:...|.|    ||   .|:||:|.
Human   553 FRHPSELRKHMRIHTGEKPYQ---CQYCEYRSADSSNLKTHIKTKHSK----EM---PFKCDICL 607

  Fly  1349 IVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASA 1413
            :.:|...|:|||             |.....|| ....|..|.|  ||:.:||........|...
Human   608 LTFSDTKEVQQH-------------TLVHQESK-THQCLHCDHK--SSNSSDLKRHVISVHTKDY 656

  Fly  1414 PLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPA 1478
            |   ::|:.|...|:...:|..|:..|.  ....:.|:.|....:....|..|....|.: ..|.
Human   657 P---HKCEMCEKGFHRPSELKKHVAVHK--GKKMHQCRHCDFKIADPFVLSRHILSVHTK-DLPF 715

  Fly  1479 ECSLCRKVFFDRQMHDNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDDDEEDDD 1543
            .|..|||                       |..||.:.:.|....:.|.::
Human   716 RCKRCRK-----------------------GFRQQNELKKHMKTHSGRKVY-------------- 743

  Fly  1544 EQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQEL 1608
             |.:..|.:.:|.:|....|.|..|.        ..|. .|..|...|......::||.:|.:|:
Human   744 -QCEYCEYSTTDASGFKRHVISIHTK--------DYPH-RCEYCKKGFRRPSEKNQHIMRHHKEV 798

Fly 1609 1608
Human 799 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	6/40 (15%)
		C2H2 Zn finger	1067..1088	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1279..1298	CDD:275371	5/18 (28%)
		C2H2 Zn finger	1308..1325	CDD:275371	5/16 (31%)
		C2H2 Zn finger	1420..1440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1450..1468	CDD:275368	4/17 (24%)
ZFY	NP_001356631.1	Zfx_Zfy_act	71..406	CDD:309717	70/348 (20%)
		COG5048	<417..592	CDD:227381	48/266 (18%)
		C2H2 Zn finger	423..443	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..478	CDD:275368	6/69 (9%)
		C2H2 Zn finger	486..506	CDD:275368	6/19 (32%)
		COG5048	539..>676	CDD:227381	43/166 (26%)
		C2H2 Zn finger	546..566	CDD:275368	6/19 (32%)
		zf-H2C2_2	558..582	CDD:338759	6/26 (23%)
		C2H2 Zn finger	574..593	CDD:275368	6/18 (33%)
		C2H2 Zn finger	603..652	CDD:275368	18/64 (28%)
		C2H2 Zn finger	660..680	CDD:275368	5/19 (26%)
		zf-C2H2	715..737	CDD:333835	8/44 (18%)
		C2H2 Zn finger	717..737	CDD:275368	8/42 (19%)
		zf-H2C2_2	729..753	CDD:338759	4/38 (11%)
		C2H2 Zn finger	745..766	CDD:275368	5/20 (25%)
		C2H2 Zn finger	774..794	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100