DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hang and Plagl2

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_061277.2	Gene:	Plagl2 / 54711	MGIID:	1933165	Length:	496	Species:	Mus musculus

Alignment Length:	391	Identity:	69/391 - (17%)
Similarity:	107/391 - (27%)	Gaps:	175/391 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly  1419 QCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKD--CGNVYSGRKSLWVHRYKKHPQVPNPAECS 1481
            ||:...:.|:..:||..|...|.|  ...|||..  ||..::.:..|:.|......|.|:  :|.
Mouse    41 QCEISGTPFSNGEKLRPHSLPHPE--QRPYSCPQLHCGKAFASKYKLYRHMATHSAQKPH--QCM 101

  Fly  1482 LCRKVFFDRQMHDNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQ 1546
            .|.|:|..:....||..|           |......||
Mouse   102 YCDKMFHRKDHLRNHLQT-----------HDPNKEALH--------------------------- 128

  Fly  1547 QLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVD 1611
                                                 |:.||..:..:..:.:|:..|
Mouse   129 -------------------------------------CSECGKNYNTKLGYRRHLAMH------- 149

  Fly  1612 NPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFR-----GDSKQNPI 1671
               ||                  .:|:.:|.:|.:||....||..|.|.|.|     ...|::|.
Mouse   150 ---AA------------------SSGDLSCKVCLQTFESTQALLEHLKAHSRRVAGGAKEKKHPC 193

  Fly  1672 DGEATQLTNNNHTTNNNNNNSMHLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKR 1736
            |                                                 |.:.....| |.::|
Mouse   194 D-------------------------------------------------HCDRRFYTR-KDVRR 208

  Fly  1737 -------KRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTK 1794
                   :::..|:|||..|...::|.||:.:.|..|:..:...||    |.|....|......|
Mouse   209 HLVVHTGRKDFLCQYCAQRFGRKDHLTRHVKKSHSQELLKIKTEPV----DMLGLLSCSSTVSVK 269

  Fly  1795 E 1795
            |
Mouse   270 E 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368
		C2H2 Zn finger	1067..1088	CDD:275368
		C2H2 Zn finger	1279..1298	CDD:275371
		C2H2 Zn finger	1308..1325	CDD:275371
		C2H2 Zn finger	1420..1440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1450..1468	CDD:275368	5/19 (26%)
Plagl2	NP_061277.2	C2H2 Zn finger	42..62	CDD:275368	5/19 (26%)
		C2H2 Zn finger	70..92	CDD:275368	5/21 (24%)
		zf-H2C2_2	85..109	CDD:372612	8/25 (32%)
		C2H2 Zn finger	100..120	CDD:275368	7/30 (23%)
		C2H2 Zn finger	129..149	CDD:275368	4/19 (21%)
		C2H2 Zn finger	158..178	CDD:275368	8/19 (42%)
		C2H2 Zn finger	193..213	CDD:275368	5/69 (7%)
		C2H2 Zn finger	221..239	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100