DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hang and ZNF107

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	866	Identity:	169/866 - (19%)
Similarity:	282/866 - (32%)	Gaps:	292/866 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1036 CPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDK-NR--HSG 1097
            |..||:.:|.::.:.:| :..|..:.|  |||..||..:.:.|.|..|.| :|..:| |:  ..|
Human   247 CEECGKAFNWFSTLTKH-KRIHTGEKP--YKCEECGKAFNQSSQLTRHKI-IHTEEKPNKCEECG 307

  Fly  1098 GFEYIVNADAVKLADGSTPN--VYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSN 1160
                    .|.|.|...|.:  ::||...|                :.||.|.|     ...||:
Human   308 --------KAFKQASHLTIHKIIHTGEKPY----------------KYEECGKV-----FSQSSH 343

  Fly  1161 --NSSLVGVASQQKECPICNAVFSNNIGLSNHMRSH-----YTASNAVNAALAAANRMTPKSLTI 1218
              ...::.......:|..|...|:....|:||.|.|     |.....            .::..|
Human   344 LTTQKILHTGENLYKCKECGKAFNLFSNLTNHKRIHAGEKPYKCKEC------------GRAFNI 396

  Fly  1219 TATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRF----RRMRCRI 1279
            ::......::..||.:                |:..:....|.|||...|.::.    :..:|..
Human   397 SSNLNKQEKIHTGGKL----------------NKCEECDKAFNRSLKLTAHKKILMEEKPYKCEE 445

  Fly  1280 CQRRFSSKKSYRYHMLTDHQVQNV--QFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQF 1342
            |.:.|:     ::..||.|::.:.  :..|||.|...|.....|..|. |:|...       |.:
Human   446 CGKVFN-----QFSTLTRHKIIHTGEKPYKCKECGKAFNQSSNLTEHK-KIHTAE-------KSY 497

  Fly  1343 ECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAG 1407
            :|:.|...::..|.|..|::                        :....||
Human   498 KCEECGKAFNQHSNLINHRK------------------------IYSGEKP-------------- 524

  Fly  1408 GSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHP 1472
                      |:|:.|...||.:..|..|...|.  ....|.|::|...:|...:|..|  ||..
Human   525 ----------YKCEECGKAFNRSSTLTRHKKIHT--GEKPYKCEECDRAFSQSSNLTEH--KKIH 575

  Fly  1473 QVPNPAECSLCRKVF--FD-----RQMHDNHTP-TCNRKPITSTGAHQQQDGQLHSH---HT--- 1523
            ....|.:|..|.|.|  |.     :::|....| .|.     ..|....|..||..|   ||
Human   576 TGEKPYKCEECGKAFNRFSTLTKHKRIHTGEKPYKCE-----ECGKAFNQSYQLTRHKIVHTKEK 635

  Fly  1524 --------------AKRTIFRHK---TGDDDDEEDDDEQQQLEERA---NSDGNGTTVGVASGST 1568
                          :.|||  ||   ||        ::..:.||..   |...|.||..:.
Human   636 LNKCEEFGKAFKQSSHRTI--HKIIHTG--------EKPYKCEEHGKVFNQSSNLTTQKII---- 686

  Fly  1569 AAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQ 1633
                                       |..:::.|.|:.             |.|    |.:...
Human   687 ---------------------------HTGENLYKFEEH-------------GKA----FNLFSN 707

  Fly  1634 NEN------GE--YACDLCAKTFPQVIALKVHRKWHFRGDSKQNPID-GEATQLTNNNHTTNNNN 1689
            ..|      ||  :.|:.|.|.:.:...|.:|::.|    :.:.|.. .|..:..|.:.|.|.:
Human   708 ITNHKIIYTGEKPHKCEECGKAYNRFSNLTIHKRIH----TGEKPYQCAECGKAFNCSSTLNRH- 767

  Fly  1690 NNSMHLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNN 1754
                  :.:| .|..|.:.::     |..:.|.::..:::: |....::..|||.|...|..::|
Human   768 ------KIIH-TGEKPYKCKE-----CGKAFNLSSTLTAHK-KIHTGEKPYKCEECGKAFNQSSN 819

  Fly  1755 LRRHMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCD 1819
            |..|. ::|..|     :|        ..|..|...|:.......||:.... .:|:
Human   820 LTTHK-KIHTSE-----KP--------YKCEECGKSFNQFSSLNIHKIIHTG-EKPY-------- 861

  Fly  1820 LCGEYLSRKEKLMNHINNHLK 1840
            .||:| .|...|.:::..|.|
Human   862 KCGDY-GRAFNLSSNLTTHKK 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1067..1088	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1279..1298	CDD:275371	4/18 (22%)
		C2H2 Zn finger	1308..1325	CDD:275371	5/16 (31%)
		C2H2 Zn finger	1420..1440	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1450..1468	CDD:275368	5/17 (29%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368
		C2H2 Zn finger	219..239	CDD:275368
		COG5048	243..621	CDD:227381	100/504 (20%)
		C2H2 Zn finger	247..267	CDD:275368	5/20 (25%)
		C2H2 Zn finger	275..295	CDD:275368	7/20 (35%)
		C2H2 Zn finger	303..323	CDD:275368	5/27 (19%)
		C2H2 Zn finger	331..351	CDD:275368	6/24 (25%)
		C2H2 Zn finger	359..379	CDD:275368	7/19 (37%)
		C2H2 Zn finger	387..407	CDD:275368	1/31 (3%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		C2H2 Zn finger	443..463	CDD:275368	6/24 (25%)
		C2H2 Zn finger	471..491	CDD:275368	7/20 (35%)
		C2H2 Zn finger	499..519	CDD:275368	5/43 (12%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		COG5048	551..>863	CDD:227381	80/417 (19%)
		C2H2 Zn finger	555..575	CDD:275368	7/21 (33%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		C2H2 Zn finger	611..631	CDD:275368	6/24 (25%)
		C2H2 Zn finger	639..659	CDD:275368	5/21 (24%)
		C2H2 Zn finger	699..715	CDD:275368	4/19 (21%)
		C2H2 Zn finger	723..743	CDD:275368	5/19 (26%)
		C2H2 Zn finger	751..771	CDD:275368	4/26 (15%)
		C2H2 Zn finger	779..799	CDD:275368	3/25 (12%)
		C2H2 Zn finger	807..827	CDD:275368	7/20 (35%)
		C2H2 Zn finger	835..855	CDD:275368	5/19 (26%)
		C2H2 Zn finger	863..883	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142201
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930