DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and ZBTB21

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001091872.1	Gene:	ZBTB21 / 49854	HGNCID:	13083	Length:	1066	Species:	Homo sapiens

Alignment Length:	1302	Identity:	228/1302 - (17%)
Similarity:	374/1302 - (28%)	Gaps:	522/1302 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   679 DYDNPEQYRPLLTRDKVEFIEQNDEFLEQYQTMTCRCCNKYFSTYKNFMAHVRKKYPQLPRNLCF 743
            |:..|:.:..:|     .:|..:..|:|:......:  ...:|...:|:.::..|.||.|...|.
Human    73 DFCEPDAFDNVL-----NYIYSSSLFVEKSSLAAVQ--ELGYSLGISFLTNIVSKTPQAPFPTCP 130

  Fly   744 NCLKMNDSKALFI----SHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAG 804
            |      .|.:|:    :..:||:.| :.:..|..:|||
Human   131 N------RKKVFVEDDENSSQKRSVI-VCQSRNEAQGKT-------------------------- 162

  Fly   805 AGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHA 869
               |:.|.|.|:          .:.||....|.:...||.:    .||.....|
Human   163 ---VSQNQPDVS----------HTSRPSPSIAVKANTNKPH----VPKPIEPLH----------- 199

  Fly   870 DVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGV 934
                  |.|:      .:.:.|.|....|               ||...|...||...:..|
Human   200 ------NLSL------TEKSWPKDSSVVY---------------AKSLEHSGSLDDPNRISL--- 234

  Fly   935 GGGAVSDNASTTGSGMARSNSMEHSPGKRSLLGALGVGSSAEESRSSSAAPPL-----TSTPKLA 994
                |..||......:....:|:..||   :.|.|..|.:.|.:......|.|     :.||.|.
Human   235 ----VKRNAVLPSKPLQDREAMDDKPG---VSGQLPKGKALELALKRPRPPVLSVCSSSETPYLL 292

  Fly   995 GGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPN 1059
            .....|.|.....:..                 |:|::..|.|..|....|.:
Human   293 KETNKGNGQGEDRNLL-----------------YYSKLGLVIPSSGSGSGNQS------------ 328

  Fly  1060 KLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYD 1124
                   ..|.|   |.:..|....:::                        |...| ||:...|
Human   329 -------IDRSG---PLVKSLLRRSLSM------------------------DSQVP-VYSPSID 358

  Fly  1125 YVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSN 1189
              :|     ::.|:.....:.||:|     |...|..|||       |:|....|:......|..
Human   359 --LK-----SSQGSSSVSSDAPGNV-----LCALSQKSSL-------KDCSEKTALDDRPQVLQP 404

  Fly  1190 HMRSHYTASNAVNAALAAANRMTPKSL-TITATPATDSELGVGGTMSE---SAPATPANVPPAMA 1250
            |....::||.:.:.  ..|:.:|...: |..::|.:|....:..|:.:   :|.|:.::|...::
Human   405 HRLRSFSASQSTDR--EGASPVTEVRIKTEPSSPLSDPSDIIRVTVGDAATTAAASSSSVTRDLS 467

  Fly  1251 NQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEF 1315
            .:|..:|....|   ..|.|||:      ..||...||
Human   468 LKTEDDQKDMSR---LPAKRRFQ------ADRRLPFKK--------------------------- 496

  Fly  1316 AYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSS 1380
                 |||:   .||                                                 |
Human   497 -----LKVN---EHG-------------------------------------------------S 504

  Fly  1381 KIDDDSLMDDGKPTSSDL----ADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHD 1441
            .:.:|:..:...||..|.    :||:....|....:.|...::||:|...|.:...|..|:|.:.
Human   505 PVSEDNFEEGSSPTLLDADFPDSDLNKDEFGELEGTRPNKKFKCKHCLKIFRSTAGLHRHVNMYH 569

  Fly  1442 EFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVF---FDRQMHDNHTPTCNRK 1503
            . ....|:|..|...:.....:|.|...:|..|.||:..|....|.   |.|::.|
Human   570 N-PEKPYACDICHKRFHTNFKVWTHCQTQHGIVKNPSPASSSHAVLDEKFQRKLID--------- 624

  Fly  1504 PITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDD--DDEEDDDEQQQLEERANSDGNGTTVGVASG 1566
                         .:......|..|.:.:.|..  ..:.....||.::....|...|..:
Human   625 -------------IVREREIKKALIIKLRRGKPGFQGQSSSQAQQVIKRNLRSRAKGAYI----- 671

  Fly  1567 STAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKH--EQELYVDNPLAAMFDDGPADAGQFQ 1629
                             ||.||..:.....|.:||:.|  |:.|.| |.:|...:..|
Human   672 -----------------CTYCGKAYRFLSQFKQHIKMHPGEKPLGV-NKVAKPKEHAP------- 711

  Fly  1630 VERQNENGE-YACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSM 1693
            :....||.| |.|.||......::
Human   712 LASPVENKEVYQCRLCNAKLSSLL----------------------------------------- 735

  Fly  1694 HLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEY-------CASTFIS 1751
                          :|.|....|.::......|....|..:|::.|.||||       |..||.|
Human   736 --------------EQGSHERLCRNAAVCPYCSLRFFSPELKQEHESKCEYKKLTCLECMRTFKS 786

  Fly  1752 NNNLRRHMYELHKHEVSNL--------------------------PEPP-----VIVVDDHLTCR 1785
            :.::.||..|:|..  :|:                          |||.     |...||::...
Human   787 SFSIWRHQVEVHNQ--NNMAPTENFSLPVLDHNGDVTGSSRPQSQPEPNKVNHIVTTKDDNVFSD 849

  Fly  1786 RC-QLKFD-------------TKELWI---EHKLADAKVVRP---FCPFQ---------WGCDLC 1821
            .. |:.||             :|:|.|   |..:.:|:...|   ..|.:         |.|:.|
Human   850 SSEQVNFDSEDSSCLPEDLSLSKQLKIQVKEEPVEEAEEEAPEASTAPKEAGPSKEASLWPCEKC 914

  Fly  1822 G------EYLSRKEKLM----------------------NHINNHL---------KEEVIVPVAT 1849
            |      :.|.|.::|:                      :|..:|:         ||..:.||.|
Human   915 GKMFTVHKQLERHQELLCSVKPFICHVCNKAFRTNFRLWSHFQSHMSQASEESAHKESEVCPVPT 979

  Fly  1850 KA 1851
            .:
Human   980 NS 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1067..1088	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1279..1298	CDD:275371	4/18 (22%)
		C2H2 Zn finger	1308..1325	CDD:275371	3/16 (19%)
		C2H2 Zn finger	1420..1440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1450..1468	CDD:275368	4/17 (24%)
ZBTB21	NP_001091872.1	BTB	20..120	CDD:279045	8/53 (15%)
		Mediates homodimerization	30..96		5/27 (19%)
		BTB	31..120	CDD:197585	8/53 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..196		15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..442		11/55 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..485		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..525		9/78 (12%)
		C2H2 Zn finger	548..569	CDD:275368	7/20 (35%)
		zf-C2H2	670..692	CDD:278523	7/43 (16%)
		C2H2 Zn finger	672..692	CDD:275370	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	806..840		3/33 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..906		4/26 (15%)
		C2H2 Zn finger	911..931	CDD:275370	5/19 (26%)
		C2H2 Zn finger	939..960	CDD:275370	1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	963..1014		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100