DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hang and Sry-delta

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	109/493 - (22%)
Similarity:	167/493 - (33%)	Gaps:	135/493 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1174 CPICNAVFSNNIGLSNHMR----------SHYTAS-------NAVNAAL---------------- 1205
            |..|.||..::.|.|:.||          |..|.|       |.:...|
  Fly     4 CFFCGAVDLSDTGSSSSMRYETLSAKVPSSQKTVSLVLTHLANCIQTQLDLKPGARLCPRCFQEL 68

  Fly  1206 -----AAANRM-TPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSL 1264
                 ...|.| |.|.||.....|..||..|           |.:....:..:....|:......
  Fly    69 SDYDTIMVNLMTTQKRLTTQLKGALKSEFEV-----------PESGEDILVEEVEIPQSDVETDA 122

  Fly  1265 DQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQ----NVQFIKCK---LCNAEFAYEKGLK 1322
            |..||..|    ..:.:.:..|....:...:.:.:.:    :.:|| |:   :.::|..|.|
  Fly   123 DAEADALF----VELVKDQEESDTEIKREFVDEEEEEDDDDDDEFI-CEDVDVGDSEALYGK--- 179

  Fly  1323 VHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSL 1387
                ...|:....:..:|| ||..|..||:|..:||:|....|   |...:........|..|
  Fly   180 ----SSDGEDRPTKKRVKQ-ECTTCGKVYNSWYQLQKHISEEH---SKQPNHICPICGVIRRD-- 234

  Fly  1388 MDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKD 1452
                    .:..:|......|.|..      ||:|||.:|:.......|:..|  :|...|.|:.
  Fly   235 --------EEYLELHMNLHEGKTEK------QCRYCPKSFSRPVNTLRHMRMH--WDKKKYQCEK 283

  Fly  1453 CGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHT-------PT--CNRKPITST 1508
            ||..:|....|:.||. :|....||..||:|...|..|:..::||       |.  |:..|
  Fly   284 CGLRFSQDNLLYNHRL-RHEAEENPIICSICNVSFKSRKTFNHHTLIHKENRPRHYCSVCP---- 343

  Fly  1509 GAHQQQDGQLHSHHTAKRTIFRH-KTGDDD------DEEDDDEQQQLEE-RANSDGNGTTVGV-A 1564
                       ...|.:.|:..| ||.:.|      :|...||||.:|| ..:.|.:...|.| .
  Fly   344 -----------KSFTERYTLKMHMKTHEGDVVYGVREEAPADEQQVVEELHVDVDESEAAVTVIM 397

  Fly  1565 SGSTAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQ 1602
            |.:...:|          .|.||...|.:::....|:|
  Fly   398 SDNDENSG----------FCLICNTNFENKKELEHHLQ 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368
		C2H2 Zn finger	1067..1088	CDD:275368
		C2H2 Zn finger	1279..1298	CDD:275371	1/18 (6%)
		C2H2 Zn finger	1308..1325	CDD:275371	4/19 (21%)
		C2H2 Zn finger	1420..1440	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1450..1468	CDD:275368	6/17 (35%)
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	46/191 (24%)
		C2H2 Zn finger	225..245	CDD:275368	3/29 (10%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		C2H2 Zn finger	281..301	CDD:275368	7/20 (35%)
		C2H2 Zn finger	310..327	CDD:275370	5/16 (31%)
		zf-C2H2	337..359	CDD:278523	6/36 (17%)
		C2H2 Zn finger	339..359	CDD:275368	6/34 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455463
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930