DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and CG6791

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster

Alignment Length:	1662	Identity:	301/1662 - (18%)
Similarity:	467/1662 - (28%)	Gaps:	637/1662 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   505 DEPIDTDDDYQMKSIDESDDMVDPTMFLERSEHEGDVPLTASDYDYTAQHGVNASSVAASLPPNA 569
            |:.:|.::|.:    :|.||       .|::..|...|    |.|..|....|...:.....|..
  Fly    54 DDLLDAEEDER----EEEDD-------YEKNSKEPKQP----DPDDDALFDFNMEPIVDIAEPQR 103

  Fly   570 VANVAAAGDSKVASCRACSLQFSTRANARRHE-------------RNLHPNLFQLSTDSPHNTPI 621
             .::|.||          .:....|...:||.             .::.|...|::....:..||
  Fly   104 -PSLAPAG----------PMSQQVRPPMQRHSFPGAGGRPRLGSGLSVRPTTSQINATDENGVPI 157

  Fly   622 TKPTPALAAALEMQRAAAAAATAEANRAAG------AAGGNISTQKYRQVVMNAFIKCEGGGYDY 680
                                     |...|      |.||....|.:.:..||...|     |:.
  Fly   158 -------------------------NYELGVVYICPACGGEFRQQDHWKRHMNHIHK-----YNT 192

  Fly   681 DNPEQYRPLLTRDKVEFIEQNDEFLEQYQTMTCRCCNKYFSTY--KNFMAHVRKKYPQLPRNL-- 741
            .....:.||   ||:            ||  .||.|||..:.:  :|.:.|   |:..||...
  Fly   193 LRGLNFTPL---DKL------------YQ--RCRECNKRIAMHSRENLLKH---KFTHLPFRCTK 237

  Fly   742 CFNCLKMNDSKALFISHLKKRNCINLFRVL----NALRGKTTTVVVPIA------------DDVA 790
            |:.|.:....:...:.||:..:|..:..::    || .|:.|.|.....            ||:.
  Fly   238 CYICKREYKYRQDLMVHLRMVHCDEVVAMMREGYNA-AGRKTRVRESRTEQLLREKSFRENDDLG 301

  Fly   791 DDGATGSI------PVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVNKL-YECK 848
            ::.....:      |.||..      .:...|.|.||.....|:.     .|.||..:.: |.|.
  Fly   302 EESDRIEVRNELLEPDADES------GTQEQTVSEEVSKKKAGTR-----GAAELCEDYIHYMCP 355

  Fly   849 LCPKGFRTKHEFRTHVYDKHADVQRKDNN------SIQCSFCGLDFADPVD----RRRHYNNMDC 903
            .|.....|..::..|:...|..|.|:..|      .:||..| .....|..    |...::::..
  Fly   356 DCGTDCDTHAQWSQHIEFVHDYVSRRGLNFRSVDMQMQCLEC-KKIVTPNTIKSLRAHKFSHLSQ 419

  Fly   904 IVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGMARSNSMEHSPGKRSLLGA 968
            ...|||..|......||..:.|:.|.|....   .:|::|... .|.|.|...:...|...  ..
  Fly   420 PEWLRCKLCYKGYTDHQEIIRHLLQQHHMDT---LMSEDAEEE-DGDAPSAIEDECDGDNG--NG 478

  Fly   969 LGVGSSAEESRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMP 1033
            .|.|:..:|.     :|.....|:        .||..|:.           |...|...|
  Fly   479 EGNGAPLDED-----SPYFEDAPR--------RGGRISSD-----------DIFEPHIDY----- 514

  Fly  1034 QVCPICGQQY------------------------------------------NNY--NNVLRHME 1054
             :||.||:::                                          |.|  .|..:|..
  Fly   515 -LCPQCGKEFIEKKHWRTHVVMAHSMNDLSKLNFEMINERQLKCTECDKIITNAYGIQNAQQHRI 578

  Fly  1055 SKHPNKLPETY-KCVRCGLGYPRISYLREHMINVHGVDKNRH-SGGFEYIVNADAVKLADGSTP- 1116
            :..|.|   .| :|.:|...|.....|.:|:...|.|...|. |||      ..|..|.....|
  Fly   579 THLPFK---AYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGG------CPAPILTPAKQPR 634

  Fly  1117 ----NVYTGRYDYVMKDLMSITNGGTLDD---------EEEE------PGSVAKKMRLDDSSNNS 1162
                .|....|:.:..|  .:..||..:|         ||:|      |.|.....:.....|:
  Fly   635 KQIVTVANETYEIIYLD--DVDQGGMEEDNDFGEQMQAEEDEYPIAPPPPSPPPPPQPTTQGNH- 696

  Fly  1163 SLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSE 1227
                   |:.:|..|..:|:....:..|:.........|.      .|..|
  Fly   697 -------QRYKCVHCGTLFATQAAVRVHISEKRCRKTVVR------RRRQP-------------- 734

  Fly  1228 LGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRY 1292
                 .||.:.|:.|          |.::..:|               .|..|...:.::..:|.
  Fly   735 -----VMSSADPSVP----------TVEQNYIF---------------LCPSCGFEYKTQFEWRR 769

  Fly  1293 HMLTDHQVQNVQFI-------------KCK--LCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQF 1342
            |:...|.....|::             :||  :||::.   |||:.|    |.:.:...:.:|
  Fly   770 HINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKL---KGLQDH----HFRHLPYRLYLK-- 825

  Fly  1343 ECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKI----DDDSLMDDGKPT--------- 1394
             |.:|...|:.:..:..|.|:.|.:......|..:...::    .|:|..:...|:
  Fly   826 -CLICGTCYNHKPNIAAHLRARHSIFDRETPTMITKPKQVLGRYKDNSRENPKLPSPPPAPALAP 889

  Fly  1395 --SSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHD--EFDSNDYSCKDCGN 1455
              .|..|..|:.||..|:.|...........|:..||   |...|:.|:  :.|...|.|..|..
  Fly   890 APPSPPACSSSAAASASSRSLKPQPGGLPARPAGLNT---LEDSISYHNAVDLDFITYFCPKCNQ 951

  Fly  1456 VYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTPTC----NRKPITST-GAHQQQD 1515
            .:........|..::|..  |..|....|::       |||...|    .|..:|.| ||    .
  Fly   952 NFDSHAFWRKHIVEQHNF--NSREGLNFRQI-------DNHHYLCLECYKRVTVTHTKGA----I 1003

  Fly  1516 GQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIP 1580
            |||.||.      |||                |..|                      |.|
  Fly  1004 GQLQSHK------FRH----------------LPHR----------------------SFK---- 1020

  Fly  1581 EVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCA 1645
               |..||..|..::.|.||:.:....  .||.....|||...|    |....:......|..|.
  Fly  1021 ---CLTCGGEFVRKQMFFKHLNRDTNR--CDNRPHREFDDDEPD----QDTLLSTIYHLTCPQCG 1076

  Fly  1646 KTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRELHAVGLMPNQQQQ 1710
            ..|      |.|.|..:|                  .|..:::....:.|..:..||
  Fly  1077 DNF------KTHNKKEWR------------------EHINDHHGLTKLELLHMTKVG-------- 1109

  Fly  1711 SLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPV 1775
                                      :...:|:.|.....:|     ..:.|..|...:||
  Fly  1110 --------------------------EDVYRCQDCDEELETN-----RQWVLQFHRFQHLP---- 1139

  Fly  1776 IVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHLK 1840
                 |....||:|        .:...||            |.|..||..|.:| |..||..|
  Fly  1140 -----HAAYIRCKL--------CKQSSAD------------GADAVGELHSLRE-LQQHIRKH-- 1176

  Fly  1841 EEVIVPVATKAAIERTAAMESAAADANAAATLSALGEGAETEDQFAEKVEAAGATTTDKLTNPDE 1905
                               .....||...:.:..:.:
  Fly  1177 -------------------HPGLGDAEMISLIEQIIQ---------------------------- 1194

  Fly  1906 EDSDDLDEDSSGDDDDSSGTGDDDDDDDSDDDEDGEGEDEDEEGDGGEGEDEEGVQP-PAQLLPQ 1969
                                         |:.|..||.::..:|:...|:|.....| |..||
  Fly  1195 -----------------------------DEKEQEEGTEQTNDGENPTGQDSGPYMPLPPHLL-- 1228

  Fly  1970 QQHKTDLNLNQDDDDLVEEVISSDDDEDDDGEVESDD 2006
                                       ||||:||.:|
  Fly  1229 ---------------------------DDDGDVEFED 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	8/64 (13%)
		C2H2 Zn finger	1067..1088	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1279..1298	CDD:275371	3/18 (17%)
		C2H2 Zn finger	1308..1325	CDD:275371	7/18 (39%)
		C2H2 Zn finger	1420..1440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1450..1468	CDD:275368	3/17 (18%)
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	6/20 (30%)
		C2H2 Zn finger	208..230	CDD:275368	8/24 (33%)
		C2H2 Zn finger	235..256	CDD:275368	3/20 (15%)
		C2H2 Zn finger	516..532	CDD:275368	4/15 (27%)
		C2H2 Zn finger	557..580	CDD:275368	4/22 (18%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		COG5236	<939..>1096	CDD:227561	52/250 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930