DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and MEP-1

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001137875.1	Gene:	MEP-1 / 38327	FlyBaseID:	FBgn0035357	Length:	1152	Species:	Drosophila melanogaster

Alignment Length:	1327	Identity:	241/1327 - (18%)
Similarity:	407/1327 - (30%)	Gaps:	409/1327 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 VQHQQAGGLATSTTTSNPPGSVVSATPSASVSASASASASVSTAPLLMPPLPAMPIKDEPIDTD- 511
            |:.||...:......||....::|| ....:|....|.||           |..|:.||.::.|
  Fly    51 VEEQQEEDVHLPEAPSNEKLELLSA-GGKDISKEDVAQAS-----------PQAPVADEIMEVDG 103

  Fly   512 ----DDYQMKSIDESDDMVDPTMFLERSEHEGDVPLTASDYDY-------------TAQHGVNAS 559
                ::.::::.||...:...:....:.:.|.:...|..|.|:             ||::...|.
  Fly   104 TEDVEENEVENDDEDSQITSSSSKEPKLDEEDEEATTNGDGDHEPEDEDDAQKIGSTAENSCEAE 168

  Fly   560 SV--AASLPPNAVANVAAA---GDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPHN- 618
            ..  |.::|.:.:|:...|   |:..|||          .............|.|..|.:...|
  Fly   169 DPLGAVTVPDDELASGKKAHLDGEESVAS----------EGVVEEEPPAKQENGFGASPNQKENG 223

  Fly   619 -TPITKPTPALAAA------------LEM----QRAAAAAATAEANRAAGAAGGNISTQKYRQVV 666
             ..|.:...|:|.:            .||    :....|..|.:|.:.|.::||..|...
  Fly   224 QASIAEARAAIAPSDGGVVNLDEDSDEEMEDITEHKEPAKPTEKAAKPASSSGGESSDDA----- 283

  Fly   667 MNAFIKCEGGGYDYDNPEQYRPL------LTRDKVEFIEQNDE-----FLEQYQTMTCRCCNKYF 720
              ..|..:........|...:.|      :....|:..|.:|:     .:|....::.....|..
  Fly   284 --VLIASDSDTESAAPPPPVKKLPPVVKAIPPPPVQDDEDDDDDDDCVVIEDDTPLSISPSGKRK 346

  Fly   721 STYKNFM----AHVRKKYPQLPRNLCFNCLKMNDSKALF------ISHLKKRNCINLFRVLNALR 775
            |...:..    :|.|:: ...|..:  ..|.:.|:::|.      .|....|:.|....:.||:.
  Fly   347 SDLDDLQLQQPSHKRQR-SSTPSGM--GQLTIKDARSLMPLDGSPSSVSGPRDSIYPVTITNAVT 408

  Fly   776 GKTTTV-VVPIADDVADDGATGSIPVADA-GAGVVAMNSPTVTASGEVVTPGGGSERPE------ 832
            |..|.: |||          ...:|:|.. .|..|.:|.||::.:|........:..|.
  Fly   409 GAATNLGVVP----------PKLVPMAGGMSASPVQLNPPTLSLTGLPSMTNNANLLPGLTDDMF 463

  Fly   833 KLRAKELLVNKLYE-------CKLCPKGFRTKHEF---------RTHVYDKHADVQRKDNNSIQC 881
            .|.|...:|..:||       |::. |...||:..         :...:|...:..::|..:.|.
  Fly   464 VLEAPSFIVPYIYEKPPRENICEVV-KAIETKYALSAEDLAEADKGDEFDMMTEQNKEDKPADQA 527

  Fly   882 SFCG-------------LDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGG 933
            ...|             .:.:|..|.....::.:..||.:.:..:|             .|.|..
  Fly   528 DESGKKKKKKRGDDESWSEQSDDDDDEDDDDDSESGVRTKVLIKEA-------------NDDLSA 579

  Fly   934 VGGGAVSDNASTTGSGMARSNSMEHSPGK----RSLLGA----LGVGSSAEESRSSSAAPPLTST 990
            :........|..|..|::.:|...:.||:    .|.||.    :|||...|..:|..........
  Fly   580 LKVAIKPAAALATAGGVSVNNPGGNKPGQENYFESPLGKFFMDIGVGLVQEYVQSDLLRLQKRKM 644

  Fly   991 PKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMES 1055
            .|....|       :.....|....|.|..||..|:..|....:.|..|..:..:...:..|.|:
  Fly   645 RKAQVQN-------SKEFEMAINALSGNLQASKTKNAPFKFRMKRCEFCNFKSESAMAMANHYET 702

  Fly  1056 KHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNR-------H---SGGFEYIVNADAVKL 1110
            .|.|.:  .|||..|.......:.:..||..||.: |.|       |   :.|||   :....||
  Fly   703 PHMNGV--LYKCNFCTFEIRNATEIVYHMEAVHNI-KARLIKPLPYHQCPNCGFE---DNGKAKL 761

  Fly  1111 ADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAK---------------KMRLDDSSN 1160
            |          |:..|..............::.|.|..:.:               .|....::.
  Fly   762 A----------RHQPVCAKKFRPELNLAPPNDWEAPAKIPRIKPRHGLVGTATAYQAMAAQAAAQ 816

  Fly  1161 NSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTA-----------------SNAVNAALA-- 1206
            .::|..:..||......|.:.:..:...|..:....|                 .||:||.|:
  Fly   817 KAALANIQQQQAAAQARNNLQAAALAAQNAAKMRQRAPQPPKQNIVRNPAPVRGGNAMNAGLSLP 881

  Fly  1207 -----AANRMT---------PKSLTITATPATDSELGVG-GTMSESAPATPANVPPAMANQTPQE 1256
                 ||.::.         ..|::||..| ..|.:|.| |..|..||...|.:.|   .|:|
  Fly   882 NSYQLAAGQLVQASKKPMAGQPSISITPLP-RQSSVGAGAGASSSKAPQAAAGMKP---GQSP-- 940

  Fly  1257 QAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGL 1321
                      :.:.:.:.:.|.||.......:..|.||...|:|
  Fly   941 ----------SGNNKAQFVICEICDGYIKDLEQLRNHMQWMHKV--------------------- 974

  Fly  1322 KVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDS 1386
                 |:|.|.|.:.   ....|..|...:.::..|::|....|.|.::|...:|:...
  Fly   975 -----KIHPKMIYNR---PPLNCQKCQFRFFTDQGLERHLLGSHGLVTSSMQEAANKGK------ 1025

  Fly  1387 LMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCK 1451
              |.|:                                                         |.
  Fly  1026 --DAGR---------------------------------------------------------CP 1031

  Fly  1452 DCGNVYSGRKSLWVHRYKKHPQVPNPA----ECSLCRKVFFDRQMHDNHTPTCNRKPITSTGAHQ 1512
            .||.:|..:  |..|..:.|.....||    :|::|...|...:..:.|..|.:     ||.|.:
  Fly  1032 VCGRMYQWK--LLNHVSRDHHMTLKPAHLSYKCTVCTATFGMYKQFETHVYTAH-----STVARK 1089

  Fly  1513 QQDGQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTS--- 1574
            ..|.:.:|                               |.|.|:|:..|::..|..||..|
  Fly  1090 AMDSKKNS-------------------------------AQSSGSGSGAGMSRSSLGAANDSLLK 1123

  Fly  1575 -LKIR-----IPEVACTICGARFTDQE 1595
             |||.     ||:.|..   .|.|:.|
  Fly  1124 PLKINDEITIIPQPASK---PRITNME 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1067..1088	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1279..1298	CDD:275371	5/18 (28%)
		C2H2 Zn finger	1308..1325	CDD:275371	0/16 (0%)
		C2H2 Zn finger	1420..1440	CDD:275368	0/19 (0%)
		C2H2 Zn finger	1450..1468	CDD:275368	6/17 (35%)
MEP-1	NP_001137875.1	BSP_II	<121..>226	CDD:283165	19/114 (17%)
		C2H2 Zn finger	951..977	CDD:275371	9/51 (18%)
		C2H2 Zn finger	989..1010	CDD:275371	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100