DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and CG2199

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	151/826 - (18%)
Similarity:	263/826 - (31%)	Gaps:	300/826 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1138 TLDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTAS---N 1199
            |:|..:|:|....|...:::.|...|    ..:..:.|..|...        ..||...|:   :
  Fly    84 TVDRVQEQPAKKTKVAEIEEPSTQES----DKKAVKVPKKNTTL--------RQRSKSIAAFPPS 136

  Fly  1200 AVNAA--------LAAANR---MTPKSL-----------TITATPATD---------SELGVGG- 1232
            .||.|        ::|:.:   .|||..           ::..|||.:         :..|.||
  Fly   137 FVNGANTNTEIEIISASPKKLDKTPKKQISRLFEDNLNDSVKLTPAKEVSSTKKAFLNLFGNGGN 201

  Fly  1233 ----TMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYH 1293
                .::||.....::..|...|.                    ...:|..|:......|.|:.|
  Fly   202 DAIEVLTESEEEEDSDKGPITINT--------------------NNFQCPECEFHAKFPKPYKEH 246

  Fly  1294 MLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQ 1358
            :..:|.:|..:...|.||...|...|.||.||...|.:..:.|...|..|        |.|.|.:
  Fly   247 LQKEHGLQRPRIYPCTLCIKTFGVLKTLKNHLRDTHSRTFESEAKTKAKE--------SKEKEAK 303

  Fly  1359 -----------------------QHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLAD 1400
                                   :.|:|..|.|....:.......:|||.  :::.|.|.|:.||
  Fly   304 SGAKNKIDAKAKETNAVSQRKKPKEKKSKEKKTEIKCNVETKVVDEIDDQ--VNNKKGTDSEDAD 366

  Fly  1401 LS-----------------------------TLAAGGSTASAP---LYWYQCKYCPSNFNTNKKL 1433
            .:                             |.|..||:||.|   ...:||:.|.....|.|::
  Fly   367 QTQATKIASFKALNESLMKKRMLENVIDSEYTFAINGSSASTPRADSNNFQCEICDCELMTAKQM 431

  Fly  1434 AIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTP 1498
            ..|:.:                         ||...|    |...:|.:|.|....:|....|
  Fly   432 QEHMKT-------------------------VHSIDK----PKVFKCHVCEKSLATKQSLKTH-- 465

  Fly  1499 TCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGV 1563
                ..:.:.||        .:.:::||.|.:      |::||.|
  Fly   466 ----MTLHADGA--------EAPNSSKRKILQ------DEDEDVD-------------------- 492

  Fly  1564 ASGSTAAAGTSLKIRIPEVA--CTICGARFTDQEHFSKHIQKHEQELYV------DNPLAAMFDD 1620
            ..|:|....|:.|:..|:.:  .....|:||::    |.:|:.::.:.:      ||  .|..|:
  Fly   493 ILGTTQIENTAEKVEGPKKSQQSPTKAAKFTNR----KILQEEDEVVEIVDAFKTDN--TAEDDE 551

  Fly  1621 GPAD----AGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNN 1681
            |||:    ..:..::.|.:.|..|        |:..|.|..:..|         :|...:
  Fly   552 GPAEEKIIRSRNNIQHQVDGGMIA--------PRSPAKKTKKTSH---------VDLSVS----- 594

  Fly  1682 NHTTNNNNNNSMHLRELHAVGLMPNQQQQSLNNSCNSSMN-----------HNNNSSSNRSKSMK 1735
              |||.|:......|:         :|.:|.:...:|.::           |......:...|..
  Fly   595 --TTNGNSPAKSEKRK---------KQDKSEDTLPSSDVDIVEEINYNVRPHKKARLESIGDSTA 648

  Fly  1736 RKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEH 1800
            .:..|.|:.|.....|...|..||.:.|..:               |.|..|:..:..:..::.|
  Fly   649 DESTLSCDRCGKFVKSRQRLDSHMEKKHAAK---------------LQCTLCKEVYQNQMDYVAH 698

  Fly  1801 KLADAKVVRPF--CPFQWGCDLCGEYLSRKEKLM---NHINNHLKE 1841
                      |  |..:.|.. ||  ::..:|:.   |.:::||::
  Fly   699 ----------FSNCGSEGGLP-CG--VANCKKVFTEANFLSSHLRK 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368
		C2H2 Zn finger	1067..1088	CDD:275368
		C2H2 Zn finger	1279..1298	CDD:275371	4/18 (22%)
		C2H2 Zn finger	1308..1325	CDD:275371	7/16 (44%)
		C2H2 Zn finger	1420..1440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1450..1468	CDD:275368	2/17 (12%)
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	5/45 (11%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440025
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930