DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and CG1233

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_612034.1	Gene:	CG1233 / 38063	FlyBaseID:	FBgn0035137	Length:	1129	Species:	Drosophila melanogaster

Alignment Length:	1425	Identity:	258/1425 - (18%)
Similarity:	410/1425 - (28%)	Gaps:	524/1425 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 GGFFDQHLHQQQQHHQHLENELEAEKEKATPTAASTAAN-----ILDGIHSLKKRKSLTVYVSPK 236
            |||||:.|            .:.:....|:.:||:|..:     :.||    ..|....|.|..:
  Fly    46 GGFFDEEL------------VIGSGSGSASASAANTTPSGTTLWLADG----GNRSPTEVAVESQ 94

  Fly   237 PQQ-MQQHQLQQLQLQPP--------ARMTATISSAQQSLQTLLLQVPASAAASCSSTSTSTTSA 292
            |.| :...|:....||.|        .|.||.|.| ::.:::.|.:..|....:.:.|..:..|:
  Fly    95 PNQGIPFVQIHTTDLQQPEKSYRNAFRRRTAEIKS-EELIKSELAEAAAKDRLNATPTPPTRNSS 158

  Fly   293 SQQREQQQ--------------------HQQRQQSH--QYRRYHHHHQQQ--------------- 320
            ....|.:.                    .|.|.|.|  |...|...|::|
  Fly   159 CASVEGKAIIQEGPPLILRCPNCPFLSLCQMRLQQHLSQGNCYMEQHRKQCPGCSNIFYTSDALS 223

  Fly   321 -------QQQQQQQHNQRGKQMLPHHQQHQQQHHRRQRQFRPQRPLPVPVVNPAPTLRKFKPKLY 378
                   |.:..:.....|:::.  ..|.::|....|.|.||                  |.:::
  Fly   224 LHLSLDHQMEDSETLALMGRKVT--EAQTKKQTQMSQSQNRP------------------KSRIF 268

  Fly   379 L-PLDITVPPLPPLPTIPSIPTLPPVGPGSIAPPPAAELLPGISGVAGMVESLSLSLPLDFSQSC 442
            : .:|....|||..|     |.:|..|       .||.:|..:.|||
  Fly   269 IKSVDCLREPLPDFP-----PLMPDSG-------SAANILDLLEGVA------------------ 303

  Fly   443 SSSGHVQHQQAGGLATSTTTSNPPGSVVSATPSASVSASASASASVSTAPLLMPPLPAMPIKDEP 507
                      .|...|..|....|.:.:.|.|...:...:..|..|.....|:|  ....:::..
  Fly   304 ----------VGASPTEQTMPTAPAANLPAPPPKPIQKISIKSVDVLRETALLP--FDFQLQNHS 356

  Fly   508 IDTDDDYQMKSIDESDDMV-------DPTMFLERSEHEGDVPLTASDYDYTAQHGVNASSVAASL 565
            ::||:     |:.|..|:|       .|.:::...:...:..:..|.....   |.|::..:|:.
  Fly   357 VNTDN-----SLPEVPDVVGEPEKPRQPKIYIRNVDILKEPMVLPSALPGL---GFNSTMPSAAE 413

  Fly   566 PPNAVANVAAA-GDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPHNTPITKPT---- 625
            |..:...|..| ||                             :||..|       :..||
  Fly   414 PGQSGLVVGGADGD-----------------------------VFQSET-------LLTPTCQLP 442

  Fly   626 ---PALAAALEM-QRAAAAAATAEANRAAGAAGGNISTQKYRQVVMNAFIKCEGGGYDYDNPEQY 686
               |:||...:| ..|....:....|   ||...::...::..:.::.       |.|:.:.|..
  Fly   443 GFEPSLAPLAQMCSEAFPFDSVLNGN---GAPAAHVENTRFSALDLDF-------GVDFVSEEAT 497

  Fly   687 RPLLTRDKVEFIEQNDEFLEQYQTMTCRCCNKYFSTYKNFMAHVRKKYPQLPRNLCFNCLKMNDS 751
            .|....|.:..:|.....||.|...|.....|    .|.|:.:|             :.||....
  Fly   498 PPPPLNDPLTMMEPQPVQLEHYMPPTAPITTK----QKIFIKNV-------------DILKAPQR 545

  Fly   752 KALFISHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAGAGVVA-MNSPTV 815
            ..|   ||:..:.:||..     |.:...::||..:.:|.. .....||......|.: :..||.
  Fly   546 GTL---HLRTVDELNLMN-----RTEVEHLIVPNLEPMAMT-MMELPPVQQQPMEVTSQLKGPTE 601

  Fly   816 T------ASGEVVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRK 874
            |      :..|......|.:.||.|.....:.:.:.|..|              |....::|..
  Fly   602 TLGEFQPSISESWPSEDGYDLPEDLECWPWMEDAVPEAGL--------------VLPTPSEVAN- 651

  Fly   875 DNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVY----------QD 929
                          |.|:|...| |.:|.:|               :...|:|          ::
  Fly   652 --------------APPLDGLSH-NAVDLLV---------------KDFSHLYAAPPEDTQNAEE 686

  Fly   930 HLGGVGGGAVSDNASTTGS-GMARSNSMEHSPGKRSLLGALGVGSSAEESRSSSAA--------- 984
            .....|.|.|......|.| |.|       |..:.:.||:|.|......:...:||
  Fly   687 GTAAGGRGTVPPLVPVTSSEGTA-------SVAQSAALGSLPVPPLVPLAAEMNAAIEKPARIYV 744

  Fly   985 -----PPLTSTPKLAGGNQVGG---GGSTSASAAAAAQSSAN-----------------RDASAP 1024
                 |.....|.|.||..|.|   |...|..||:..:.|..                 |..|..
  Fly   745 ANNLLPAAVDPPLLGGGTSVRGRPYGAKHSGGAASKRKLSLGPNQVPEGGKCLVEGCMFRFKSPV 809

  Fly  1025 KSQYFSR---------MPQVCPIC-GQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISY 1079
            ..:|..|         .|.|||.| ...::|:|.:..|:...|...: |.|.|..|....|..|.
  Fly   810 TLEYHGRCHNGSLSSNQPVVCPECKSSNFSNWNCLHTHLWRTHQIDM-ELYSCQLCSFKTPIYSR 873

  Fly  1080 LREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEE 1144
            |......:|..::|
  Fly   874 LVNTHAKIHSEERN--------------------------------------------------- 887

  Fly  1145 EPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAAN 1209
                                       .:|..|...|.|...|.||.|.|.|..
  Fly   888 ---------------------------YKCEQCGKGFKNTKQLKNHRRLHRTQG----------- 914

  Fly  1210 RMTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRR 1274
                              ||:|...:|.....|...|..|
  Fly   915 ------------------LGMGKQSNEQISVGPEGNPVVM------------------------- 936

  Fly  1275 MRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMII 1339
            .||..|...|..||:.|.|:..:...|    ::|..|...|..:..|::||        :.....
  Fly   937 HRCEDCGAAFKQKKTLREHLCKERNEQ----LECPECQRRFGSKSSLRLHL--------RSHQEH 989

  Fly  1340 KQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSA------STSSKIDDDSLMDDGKPTSSDL 1398
            |:|.||.|....|..:..::| .:.||.:...:....      ||:.:|.        ..|....
  Fly   990 KRFRCDTCDHETSDHNAYRRH-LATHKESKRYSCPHCDFRAIQSTAFRIH--------LQTRHPE 1045

  Fly  1399 ADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKK--LAIHINSHDEFDSNDYSCKDCGNV 1456
            .:|||:.            |:|..|  ||.:..:  |.:|...||..:.|.......|:|
  Fly  1046 QELSTII------------YKCNQC--NFTSINQGLLQVHQAKHDAGNHNQTLASSQGDV 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1067..1088	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1279..1298	CDD:275371	6/18 (33%)
		C2H2 Zn finger	1308..1325	CDD:275371	4/16 (25%)
		C2H2 Zn finger	1420..1440	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1450..1468	CDD:275368	2/7 (29%)
CG1233	NP_612034.1	C2H2 Zn finger	830..852	CDD:275368	6/21 (29%)
		C2H2 Zn finger	861..882	CDD:275368	5/20 (25%)
		zf-H2C2_2	875..899	CDD:290200	5/101 (5%)
		zf-C2H2	888..910	CDD:278523	8/21 (38%)
		C2H2 Zn finger	890..910	CDD:275368	8/19 (42%)
		zf-C2H2_2	893..999	CDD:289522	36/171 (21%)
		C2H2 Zn finger	939..956	CDD:275368	6/16 (38%)
		RPB9	966..1061	CDD:224510	26/125 (21%)
		C2H2 Zn finger	966..986	CDD:275368	6/27 (22%)
		C2H2 Zn finger	994..1014	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1022..1042	CDD:275368	3/27 (11%)
		C2H2 Zn finger	1055..1075	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100