DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and row

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001260992.1	Gene:	row / 36685	FlyBaseID:	FBgn0033998	Length:	1301	Species:	Drosophila melanogaster

Alignment Length:	1396	Identity:	248/1396 - (17%)
Similarity:	404/1396 - (28%)	Gaps:	466/1396 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   932 GGVGGG-----------AVSDNASTTGSGMARSNSMEHSPGKRSLLGALGVGSSAEESRSSSAAP 985
            ||.|.|           |..:::......|..:..:..|.||:::         |..:.|||..|
  Fly    97 GGTGRGRGRPPRQPSNIAYLESSDEGDDDMPLAKRLALSAGKKAV---------AVANASSSFTP 152

  Fly   986 PLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVL 1050
               .:.|.|.....||..|....::......:..|..:|...|  |..:|..:.|....:.:...
  Fly   153 ---KSSKKAASAASGGSSSPVPKSSGKLFKESKPDIESPPKNY--RPAEVNSVGGLVVGSTDESK 212

  Fly  1051 RHMESK--HPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADA-VKLAD 1112
            ...:.|  ..||:.        |..||.:..|.:..:.:..:...|.        ..|: |||..
  Fly   213 DSKDGKDGKDNKMQ--------GKTYPSLVVLAKPFLKIKDMAATRS--------KLDSKVKLVL 261

  Fly  1113 GSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPIC 1177
            ..|||.:.   ::::::                 |.:..:....:..||...:|:.|.
  Fly   262 MLTPNKFC---EWLLQE-----------------GLLRAQQHCINHRNNELKLGIYSD------- 299

  Fly  1178 NAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELGVGG--TMSESAPA 1240
                                                    :|..|.|      ||  .:||..|.
  Fly   300 ----------------------------------------VTKFPYT------GGYVWISECCPY 318

  Fly  1241 TPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQN-VQ 1304
                          :..:||..|:.:.|            |...:......||......:|| ||
  Fly   319 --------------RFVSVFNNSIFEGA------------QHPPTFLLKLIYHWACQTSIQNVVQ 357

  Fly  1305 FIKCKLCNAEFAYEKGLKVHL-----FKVH---------GKAIKDEMII----------KQFECD 1345
            ::|     .:..|.||:...|     ..||         ||.::..:|.          :|.:.:
  Fly   358 WVK-----VDSVYIKGIYTWLRAICTLAVHQKCKKLGGPGKFVEVGVISLGTTSQDGSQRQVKVE 417

  Fly  1346 VCSIVYSSESELQQHKRSVHKLTSAS-------------ASTSASTSSKIDDDSLMDDGKPTSSD 1397
            |..:...:|..::  .|:|..:|...             .|......|.|..|..:|.....|..
  Fly   418 VLGVYDYAEKSIR--LRAVEPITDGDRNYKKRFQAILEPLSRWVHKDSTICIDLTVDKITLFSMG 480

  Fly  1398 LADLSTLAAGGSTA----SA------------------------------PLYWYQC--KYCPSN 1426
            ..::...||..:||    ||                              .|.|.:.  .|....
  Fly   481 FKNIVQAAATDNTAKHNNSAVMEYLRRIVPRMFQNTLSLLSRQMIQQFLDELVWRESFGTYALQA 545

  Fly  1427 FNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLW---VHRYKKHP--------QVP-NPAE 1479
            ||   .:.|||.......:|:...:....|.:.....|   ...||:.|        :.| |.|:
  Fly   546 FN---NIIIHIAEQTRVTTNETITQRLYQVATNPFKDWSILPANYKETPANAAPKRLKKPINDAD 607

  Fly  1480 CSLCRKV---FFDRQMHDN-----------HTP----TCNRKPITSTGAHQQQDGQLHSHHTAK- 1525
            ..:..|:   ..||.:..:           .||    ...:.|....|:..|..|...:..::|
  Fly   608 YVVSNKIPKKEKDRDIASSGVKRGRPPNALGTPPPQLPIKKGPGRPPGSTNQTKGDRATTSSSKS 672

  Fly  1526 --RTIFRHKTGDDDDEED----------DDEQQQLEE--RANSDGNGTTVGVASGSTAAAGTSLK 1576
              :::.....|....|:|          :|:.:.|||  ...|||......:...||..  |...
  Fly   673 LSKSLIAKGLGKKPKEKDEKIPMVIKKEEDDLRGLEELYYGISDGTDEYHEIFPYSTPR--TVHN 735

  Fly  1577 IRIPEVACTIC--GARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEY 1639
            .....|.|.||  |..|...|....|:..|                         :..:.:..::
  Fly   736 ELAKTVECPICLNGDSFDSNEKLQTHLVSH-------------------------ISPEGKQHQF 775

  Fly  1640 ACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRELHAVGLM 1704
            .|..|.:..|....|..|.:.....::|..........:....|       ||:||...|   |.
  Fly   776 QCLFCLEKHPTESVLAKHNQIMHPTETKTEGSPSYYCLICQQRH-------NSLHLLTAH---LQ 830

  Fly  1705 PNQQQQSLNNSCNSSMNHNNNSSSNRS------KSMKRKRELKCEYCASTFISN-----NNLRRH 1758
            .......|...|:|.   ...|||:|.      ...|.:..|:|.||...|..:     |.||..
  Fly   831 KVHSTLELPYWCHSC---GYRSSSHRDLVRHFYDDHKHQNFLQCPYCLDIFYFSKLGVVNQLRIE 892

  Fly  1759 MYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKF----DTKELWIEHKLADAKVVRP--------- 1810
            .|.:|..|..|..:|       .|.|::|.|.|    |.|:..::|.::..|..||
  Fly   893 HYFMHLDEHINKRDP-------SLRCQKCSLSFLEKGDLKQHAVQHHVSMTKTNRPVRLLLNNSM 950

  Fly  1811 ------------------------FCPFQWG--CDLCGEYLSRKEKLMNHINNHLKEEVIVPVAT 1849
                                    |..|..|  |..|....:.:|   .|....|.   .|....
  Fly   951 LIPPPKIRTHHREQPPFSTYKRPVFFAFLEGKTCAECNTDFASEE---THYTGWLH---CVKCNY 1009

  Fly  1850 KAAIERTAAMESAAADANAAATLS-------------ALGEGAETEDQFAEKVEAAGATTTDKLT 1901
            :...||.........:.|....:.             |.|.|    ::.|:.:...|.:|.....
  Fly  1010 QTCCERAQFRHGVECNGNFVDAMEVNMPQEMHCICGFATGNG----NKMAQHLANCGLSTCYPSL 1070

  Fly  1902 NPDEEDS------DDL-----DEDSSGDDDDSSGTGDDDDDDDSDDDEDGEGEDEDEEGDGGEGE 1955
            ....|::      |.|     |.::||:..|.|.|.||..|..||
  Fly  1071 EAASENAVKRNMLDMLGLVRRDGETSGEGADISETADDVADQSSD-------------------- 1115

  Fly  1956 DEEGVQPPAQLLPQQQHKTDL--------NLNQDDDDLVEEVISSDDDEDDDGEVESDDDDEDDD 2012
                :.||.:....|||...:        ..|:...:|.:|.:|:              ..|.:.
  Fly  1116 ----MLPPQEDHHLQQHHQQVGHQQQMQGQPNEPQAELQQEYLSA--------------PVEHEP 1162

  Fly  2013 DEEDDVEEPEPVGLTVRPLMNGKSKMPPLIVASSDDEDDGVMPIEDIIEEEFDEDADPDPEDAIE 2077
            .:...|.:..||..| .|:..|:.:..|:::    |....|.|..|..:....:.........:.
  Fly  1163 VQNMPVHQSMPVQQT-GPIQFGEMEAAPVLL----DTQQQVQPTPDYAQVSVVQQHQQQQPYGLS 1222

  Fly  2078 EVDED----DLDE---GEVEDEPNVVSTASF 2101
            ...:.    |:|.   ||: .|||...|..|
  Fly  1223 NYGQSSLATDIDMPLIGEL-SEPNAPPTPQF 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	2/22 (9%)
		C2H2 Zn finger	1067..1088	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1279..1298	CDD:275371	3/18 (17%)
		C2H2 Zn finger	1308..1325	CDD:275371	3/16 (19%)
		C2H2 Zn finger	1420..1440	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1450..1468	CDD:275368	2/20 (10%)
row	NP_001260992.1	C2H2 Zn finger	777..798	CDD:275368	5/20 (25%)
		C2H2 Zn finger	812..833	CDD:275368	7/30 (23%)
		C2H2 Zn finger	842..858	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100