DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and Zfp451

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001028877.2	Gene:	Zfp451 / 316312	RGDID:	1305865	Length:	1052	Species:	Rattus norvegicus

Alignment Length:	1054	Identity:	177/1054 - (16%)
Similarity:	312/1054 - (29%)	Gaps:	400/1054 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   692 RDKVEFIE----QNDEFLEQY-QTMTCR-CCNKYF------------STYKNFMA--HVRKKYPQ 736
            |:|::|..    |..||::.: :|...| |.:::.            .:.|:|.:  .:|:....
  Rat   104 REKIDFQHAHGLQELEFIQGHSETEAARQCVDQWLKMSGLRTSAINSGSKKSFQSGGRMRRSDKS 168

  Fly   737 LPRNLC--FNCLKMNDSKALFISHLKKRN---CINLFRVLNALRGKTTTVVVPIADDVADDGATG 796
            :   ||  .:|.|..|:..|.:.|||:.:   |
  Rat   169 I---LCPIMHCNKEFDNGHLLLGHLKRFDHSPC-------------------------------- 198

  Fly   797 SIPVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFR 861
                           .||:|..|.:.                    .::.|.:|.:.|.|:.:::
  Rat   199 ---------------DPTITLHGPLA--------------------NVFACAVCYEHFVTQQQYK 228

  Fly   862 THVYDKHADVQRKDNN-------SIQCSFCGLDFADP------VDRRRHYNN------------- 900
            .|:..|.|......|:       ...|..|.|.|:..      :..:.|::.
  Rat   229 DHLLSKAAAADGHSNDLPPQIIQCFACPHCFLLFSTKDECLKHMSAKNHFHQSLKLGDDKGTARP 293

  Fly   901 ---------------MDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSG- 949
                           .|....::|:.|...|.:|.....| ::......|..|:::.:.|..:.
  Rat   294 VSFPSFAKKLLVSLCKDVPFLVKCVACHQTLRSHMELSAH-FRVRCRNAGPVAIAEKSITQVAKE 357

  Fly   950 --------------MARSNSMEH-SPGKRSLLGALGVGSSAEES------RSSSAAPP----LTS 989
                          |..:::..| :||.:     :...:|.|||      .|..:.||    |.:
  Rat   358 FLVRGYCSDCNQVFMDEASTQSHKNPGHK-----MSFANSVEESVLLYCHISEGSRPPCDLHLFN 417

  Fly   990 TPKLAGGNQVGGGGSTSASAAAAAQSSAN-----RDASAPKSQYFSRMPQVCPICGQQYNNYNNV 1049
            .||::...::.....:||..........|     :..:|...:..|.:......|.:::.:.:.|
  Rat   418 QPKISSLKRILSSKESSAEDCVIPTKKVNLGVDSQGGTARVQRQRSTVTAWFCECSRRFPSEDAV 482

  Fly  1050 LRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEY--------IVNAD 1106
            .:|:.|.:    ...||||.||........:|.||...||   ..|...|.:        ::..|
  Rat   483 EKHVFSAN----TMCYKCVVCGKVCEDSGVMRLHMSRFHG---GAHLNNFLFWCRMCKKELIRKD 540

  Fly  1107 AVKLADGSTPNVYTG-RYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQ 1170
            |:.   ......::| ||.|.|             ||.|                    ..|.|.
  Rat   541 AIM---AHVTEFHSGHRYFYEM-------------DEVE--------------------AAVPSS 569

  Fly  1171 QKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELGVGGTMS 1235
            ..|               ||:.:.                ..|..:.:
  Rat   570 STE---------------NHLNAD----------------KPPSPIAV----------------- 586

  Fly  1236 ESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYH--MLTDH 1298
              ...:||:.||.                        .|.:||||:..|.|.:..:.|  .||.|
  Rat   587 --VDHSPASSPPR------------------------GRWQCRICEDMFDSHECVQQHCASLTSH 625

  Fly  1299 QVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRS 1363
            :...   ..|..|...|...:.|..|....|...::     ..:.|.:|.::::.|.....|...
  Rat   626 RFHR---YSCAHCRKTFHKVETLCRHCQDEHSGEVR-----MMYCCGLCDLIFNKEEAFLSHYTE 682

  Fly  1364 VHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFN 1428
            .|............||.|.:||          ..:.:.|.|.:.|...|     |.||
  Rat   683 QHSGDYVFVPEKTKTSIKTEDD----------FKIIETSNLLSCGCHES-----YICK------- 725

  Fly  1429 TNKKLAIHINSHDEFD----------SNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAE---- 1479
                    :|..|::|          ...:.|..|.........:..|..:.|.:|....|
  Rat   726 --------VNRRDDYDRCLQIMLEKGKLWFRCGSCSATAQNLADINTHVCQAHRKVRGDEEQQYV 782

  Fly  1480 --CSLCRKVFFD---RQMHDNHTPTCNRKPITSTGAHQQQD----GQL-----HSHHTAKRTIFR 1530
              |.:|.|.|.:   .|.|.:......:||:|   ||.:.|    |||     |:....:.|.::
  Rat   783 IKCGVCTKAFHNTESAQQHFHRKHAAFQKPVT---AHVRADHGSTGQLAASVSHAEKNPRHTSYQ 844

  Fly  1531 HKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEV--ACTICGARFTD 1593
            ..:..:...|.|...|.:||                         ::.:|:|  ..|:....|.|
  Rat   845 KCSDVERSAEHDVCCQNIEE-------------------------EVELPDVDYLRTMTHIVFVD 884

  Fly  1594 QEHFSK---HIQKH 1604
            .:::|.   |:..|
  Rat   885 FDNWSNFFGHLPGH 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1067..1088	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1279..1298	CDD:275371	7/20 (35%)
		C2H2 Zn finger	1308..1325	CDD:275371	4/16 (25%)
		C2H2 Zn finger	1420..1440	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1450..1468	CDD:275368	3/17 (18%)
Zfp451	NP_001028877.2	zf-Di19	630..685	CDD:398954	10/59 (17%)
Zfp451	NP_001028877.2	PIN_11	876..993	CDD:408272	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100