DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hang and Zfp316

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001100591.1	Gene:	Zfp316 / 304293	RGDID:	1311647	Length:	1016	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	174/968 - (17%)
Similarity:	264/968 - (27%)	Gaps:	370/968 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   975 AEESRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPIC 1039
            |:..|..:|..|.        |.:..|.|....|..|..|.:           :....|..||.|
  Rat   353 AKHQRYHAAVKPF--------GCEECGKGFVYRSHLAIHQRT-----------HTGEKPFPCPDC 398

  Fly  1040 GQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVN 1104
            |:::...::::.|... |..:.|  |:||.||.|:.|.|||..|        :..|:|...|
  Rat   399 GKRFVYKSHLVTHRRI-HTGERP--YRCVFCGAGFGRRSYLVTH--------QRTHTGERPY--- 449

  Fly  1105 ADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSL----- 1164
                       |.::.||                                  ..|.:|:|
  Rat   450 -----------PCLHCGR----------------------------------SFSQSSALARHQA 469

  Fly  1165 VGVASQQKECPICNAVFSNNIGLSNHMRS----------------HYT--ASNAVNAALAAANRM 1211
            |..|.:...||.|...|........|.|.                |..  |.|.|..|:||....
  Rat   470 VHTADRPHCCPDCGQAFRLRADFQRHRRGGGCTEPSSGDGALTAPHEVGMAPNEVEMAIAAVATA 534

  Fly  1212 TPKSL-TITATPATDSELGVGGTMSE----------SAPATPANVPPAMANQTPQEQAVFRRSLD 1265
            .|:.| :..|....:.:.||....:|          .|.|..|.||.:..:..|
  Rat   535 EPEELESGLAEKNEEPKAGVADGDNEVEVRQDEQVVVAAAAEATVPDSKKDPEP----------- 588

  Fly  1266 QAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHG 1330
               |||||.|...:.:....|...:.:|                                |.:|.
  Rat   589 ---DRRFREMGNGLAEGEGPSSHRFGFH--------------------------------FPMHP 618

  Fly  1331 KA--IKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKP 1393
            |:  ..|...:..|.        .....||...|.:.....|..|..   ...:..|.....|..
  Rat   619 KSWLHPDGFPLLGFP--------EFSERLQTDGRHLPGPLGAPLSLQ---GMGLACDPFRSAGPG 672

  Fly  1394 TSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYS 1458
            ..:|....:...|.||..|.|        .|:....              :.:.:.|.|||..:.
  Rat   673 ARADSGLRAFAPAVGSLLSEP--------APAALAE--------------EESPWICSDCGKTFG 715

  Fly  1459 GRKSLWVHRYKKHPQVPNPAECSLCRKVFF-------DRQMHDNHTPTCNRKPITSTGAHQQQDG 1516
            .|.:|..|  :::.....|..|:.|.|.|.       .|:.|....|.    |....||...:..
  Rat   716 RRAALAKH--QRYHAGERPHRCADCGKSFVYGSHLARHRRTHTGERPF----PCPECGARFARGS 774

  Fly  1517 QLHSH---HTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIR 1578
            .|.:|   ||.::..
  Rat   775 HLAAHVRGHTGEKPF-------------------------------------------------- 789

  Fly  1579 IPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDL 1643
                .|.:|||.|:.:.|.:.|.:.|..|    .|                         |||..
  Rat   790 ----VCGVCGAGFSRRAHLTAHGRAHTGE----RP-------------------------YACAE 821

  Fly  1644 CAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRELHAVGLMPNQQ 1708
            |.:.|.|..||..|:..|......:.|
  Rat   822 CGRRFGQSAALTRHQWAHAEEKPHRCP-------------------------------------- 848

  Fly  1709 QQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEP 1773
                  .|.....|:::...:| ::...::..:|..|...|...:||.:|    .:......|.|
  Rat   849 ------DCGKGFGHSSDFKRHR-RTHTGEKPFRCADCGRGFAQRSNLAKH----RRGHTGERPFP 902

  Fly  1774 PVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNH 1838
                      |..|..:|..:.:.:.|:..... .||:.     |..||...|:...|:.|:..|
  Rat   903 ----------CPECGKRFSQRSVLVTHQRTHTG-ERPYL-----CSNCGRRFSQSSHLLTHMKTH 951

  Fly  1839 LKEEVIVPVATKAAIERTAAMESAAADANAAATLSALGEGAETEDQFAEKVEAAGATT 1896
            ..:       ..|..:.|:|...|.|.|......|..|.||.|      .:|.||.|:
  Rat   952 RGQ-------GGAPAQNTSAKAQAPAKAIPPLPPSGSGSGAGT------LLEFAGGTS 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1067..1088	CDD:275368	10/20 (50%)
		C2H2 Zn finger	1279..1298	CDD:275371	2/18 (11%)
		C2H2 Zn finger	1308..1325	CDD:275371	0/16 (0%)
		C2H2 Zn finger	1420..1440	CDD:275368	1/19 (5%)
		C2H2 Zn finger	1450..1468	CDD:275368	7/17 (41%)
Zfp316	NP_001100591.1	KRAB	151..211	CDD:214630
		KRAB	151..190	CDD:279668
		COG5048	<335..495	CDD:227381	44/219 (20%)
		C2H2 Zn finger	339..359	CDD:275368	2/5 (40%)
		C2H2 Zn finger	367..387	CDD:275368	5/30 (17%)
		zf-C2H2	367..387	CDD:278523	5/30 (17%)
		zf-H2C2_2	379..404	CDD:290200	7/35 (20%)
		C2H2 Zn finger	395..415	CDD:275368	5/20 (25%)
		zf-H2C2_2	407..432	CDD:290200	9/27 (33%)
		C2H2 Zn finger	423..443	CDD:275368	10/27 (37%)
		zf-H2C2_2	435..460	CDD:290200	9/80 (11%)
		C2H2 Zn finger	451..471	CDD:275368	5/53 (9%)
		zf-H2C2_2	463..486	CDD:290200	6/22 (27%)
		C2H2 Zn finger	479..497	CDD:275368	5/17 (29%)
		C2H2 Zn finger	707..727	CDD:275368	7/21 (33%)
		zf-H2C2_2	719..744	CDD:290200	7/26 (27%)
		C2H2 Zn finger	735..755	CDD:275368	5/19 (26%)
		zf-H2C2_2	747..772	CDD:290200	6/28 (21%)
		COG5048	<760..947	CDD:227381	51/338 (15%)
		C2H2 Zn finger	763..783	CDD:275368	4/19 (21%)
		zf-H2C2_2	775..800	CDD:290200	9/78 (12%)
		C2H2 Zn finger	791..811	CDD:275368	7/19 (37%)
		C2H2 Zn finger	819..839	CDD:275368	7/19 (37%)
		zf-C2H2	845..867	CDD:278523	4/66 (6%)
		C2H2 Zn finger	847..867	CDD:275368	4/64 (6%)
		zf-H2C2_2	859..884	CDD:290200	4/25 (16%)
		C2H2 Zn finger	875..895	CDD:275368	6/23 (26%)
		zf-H2C2_2	887..912	CDD:290200	8/38 (21%)
		C2H2 Zn finger	903..923	CDD:275368	4/19 (21%)
		zf-H2C2_2	916..940	CDD:290200	6/29 (21%)
		C2H2 Zn finger	931..951	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100