DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hang and Zfp438

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001347376.1	Gene:	Zfp438 / 240186	MGIID:	2444919	Length:	798	Species:	Mus musculus

Alignment Length:	786	Identity:	142/786 - (18%)
Similarity:	245/786 - (31%)	Gaps:	287/786 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   756 ISHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGE 820
            :|.|...:|.:|  .|:|:...||          .|..:..|:|.:...||.....:||
Mouse   198 LSPLVTNSCGDL--ELSAMPVYTT----------EDSSSQQSLPASMQKAGCARKEAPT------ 244

  Fly   821 VVTPGGGSE--RPEKLRAKELLVNKLYECKLCPKGF-------RTKHEFRTHVYDKHADVQRKDN 876
              ||...||  :.:...|:.:|.:.:....:.|||.       |.|   .|.|....:|.   ||
Mouse   245 --TPAIASEELKEQLASAQTVLSSAVQLLSVVPKGKLPILPLPRVK---TTEVGKVESDA---DN 301

  Fly   877 NSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQ--DHLGGVGGGAV 939
            ..:..|.|..:                        ||.:|...:.| |...:  ..:..:.|...
Mouse   302 AELSLSGCRAN------------------------CDERLSITEGF-DAATEIASKIAALHGSKQ 341

  Fly   940 S--------------DNASTTGSGMARSNSMEHSP-------GKR--SLLGALGVG-----SSAE 976
            |              .:.:...||:.|.......|       |||  .::|..|.|     :|.:
Mouse   342 SACESAFCPVTKLDLSHKAKPSSGIKRRGRKWKVPDEILALQGKRRKCIIGMCGDGIERARNSPQ 406

  Fly   977 ESRSS--------------------SAAPPLTS-TPKLAGGNQVGGGGSTSASAAAAAQSSANRD 1020
            |:|..                    ||..||.| |..|:......|....:.:..:....|...|
Mouse   407 EARDQKPRVASRKYRNIMPKPVLVLSALAPLASHTAVLSQAPSSLGQDVLNNALPSKCLGSKQSD 471

  Fly  1021 ASAPKSQY-----FSRMPQ---VCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRI 1077
            :|.||...     ||.:.:   :||:|...:...:::|.||.: |.|:.|  |.|..|     |.
Mouse   472 SSTPKPSSVLRNGFSGIKKPWHMCPVCNYHFQFKHHLLDHMNT-HTNRRP--YSCGIC-----RK 528

  Fly  1078 SYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDE 1142
            :|:|
Mouse   529 TYVR------------------------------------------------------------- 532

  Fly  1143 EEEPGSVAKKMRLDDSSNN-SSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALA 1206
               |||::..|:|....|: ..||.       |..|..||       .|:|.::       ..|.
Mouse   533 ---PGSLSAHMKLHHGDNHPKKLVC-------CEFCAKVF-------GHVRVYF-------GHLK 573

  Fly  1207 AANRMTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRR 1271
            ..:|:      :.:|..:.|||..|.|             |...|:.|..|..     |.:.:|
Mouse   574 EVHRV------VISTEPSPSELQPGDT-------------PKNKNRDPGMQGP-----DNSLER- 613

  Fly  1272 FRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIK-- 1334
                     :.:.|.::.:..:...:.::|    |:|..|.........:|.||..|||:.|:
Mouse   614 ---------ETKSSLEEDFLLNQADEVKLQ----IRCGRCQITAQSFAEIKFHLLHVHGEEIQGR 665

  Fly  1335 -DEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKID------DDSLMDDGK 1392
             .|||:.....|.     ..:.:..:.::.:....|...|.:.....::.      :::|:.
Mouse   666 LQEMILPGSRSDA-----PHQKQYTERRKQMKPYASLEDSPAFPRVKRLPAPHQNREEALVG--- 722

  Fly  1393 PTSSDLADLSTLAAGGSTASAPLYW----YQCKYCPSNFNTNKKLAIH-INSHDEFDSNDYSCKD 1452
                  ::.......||...|.|.|    :.|..|.......:.|.:| ::.|        :|:|
Mouse   723 ------SEGGQWGMAGSQHPAKLLWSHTGFNCLLCAQMLGRKEDLLLHWVHKH--------NCED 773

  Fly  1453 CGNVYS 1458
            ...:::
Mouse   774 PSRLWA 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1067..1088	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1279..1298	CDD:275371	1/18 (6%)
		C2H2 Zn finger	1308..1325	CDD:275371	3/16 (19%)
		C2H2 Zn finger	1420..1440	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1450..1468	CDD:275368	2/9 (22%)
Zfp438	NP_001347376.1	C2H2 Zn finger	495..515	CDD:275368	6/20 (30%)
		zf-H2C2_2	507..532	CDD:372612	11/32 (34%)
		zf-C2H2	521..543	CDD:333835	10/90 (11%)
		C2H2 Zn finger	523..543	CDD:275368	9/88 (10%)
		C2H2 Zn finger	554..573	CDD:275368	6/39 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100