DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hang and ZNF787

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001002836.2	Gene:	ZNF787 / 126208	HGNCID:	26998	Length:	382	Species:	Homo sapiens

Alignment Length:	363	Identity:	86/363 - (23%)
Similarity:	122/363 - (33%)	Gaps:	103/363 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   784 PIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVNKLYECK 848
            |:...:.||....|.|             ||..:..:...|.|...||.....        |.|.
Human    26 PVDILIMDDDDVPSWP-------------PTKLSPPQSAPPAGPPPRPRPPAP--------YICN 69

  Fly   849 LCPKGFR-----TKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADP---VDRRRHYNNMDCIV 905
            .|.|.|.     |:|: |||..::        .|:  |:.||..|:..   |..||.:.......
Human    70 ECGKSFSHWSKLTRHQ-RTHTGER--------PNA--CADCGKTFSQSSHLVQHRRIHTGEKPYA 123

  Fly   906 RLRC---MTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGMARSNSMEHSPGKRSLLG 967
            .|.|   .:..:.|..|||.       |.|...........|.|.|.....:...||..|..:..
Human   124 CLECGKRFSWSSNLMQHQRI-------HTGEKPYTCPDCGRSFTQSKSLAKHRRSHSGLKPFVCP 181

  Fly   968 ALGVGSS------------AEESRSSSAAPPLTSTPKLAGGNQ---------------------V 999
            ..|.|.|            .|.|....||..|.::.:.|.|.:                     |
Human   182 RCGRGFSQPKSLARHLRLHPELSGPGVAAKVLAASVRRAKGPEEAVAADGEIAIPVGDGEGIIVV 246

  Fly  1000 GGGGSTSASAAAAAQSSA------NRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHP 1058
            |..|..:|:|||.|.:.|      :|.|.|||       |.||..||:.:.:...:|.|..::|.
Human   247 GAPGEGAAAAAAMAGAGAKAAGPRSRRAPAPK-------PYVCLECGKGFGHGAGLLAHQRAQHG 304

  Fly  1059 NKL------PETYKCVRCGLGYPRISYLREHMINVHGV 1090
            :.|      ...:.||.||.|:.:.:.||.|. .:|.|
Human   305 DGLGAAGGEEPAHICVECGEGFVQGAALRRHK-KIHAV 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1067..1088	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1279..1298	CDD:275371
		C2H2 Zn finger	1308..1325	CDD:275371
		C2H2 Zn finger	1420..1440	CDD:275368
		C2H2 Zn finger	1450..1468	CDD:275368
ZNF787	NP_001002836.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65		11/51 (22%)
		COG5048	<67..200	CDD:227381	34/150 (23%)
		C2H2 Zn finger	68..88	CDD:275368	7/20 (35%)
		C2H2 Zn finger	96..116	CDD:275368	7/19 (37%)
		C2H2 Zn finger	124..144	CDD:275368	6/26 (23%)
		C2H2 Zn finger	152..172	CDD:275368	3/19 (16%)
		C2H2 Zn finger	180..200	CDD:275368	3/19 (16%)
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		C2H2 Zn finger	319..339	CDD:275368	8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100