DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hang and Zbtb21

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_780637.2	Gene:	Zbtb21 / 114565	MGIID:	1927240	Length:	1094	Species:	Mus musculus

Alignment Length:	1052	Identity:	190/1052 - (18%)
Similarity:	295/1052 - (28%)	Gaps:	389/1052 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 PGKRSLLGALGVGSSAEESRSSS-----AAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQS---- 1015
            |||.|......:..:|..|.|:|     :.|.:...|:......:.....|..|||..|:|
Mouse   187 PGKASGPAMQDLSHTARASPSASVKTTISKPHVAKPPEQLHSLPLTEKSWTKDSAAVYAKSLEQA 251

  Fly  1016 ----------------------SANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLR-HMESKH 1057
                                  |.:|:|:..|....|::|:...|..........||. |..|:.
Mouse   252 GALDDPNRGSLVKRNTVLPPKPSQDREATDDKPGVSSQLPKGKAIELALKRPRPPVLSLHSSSET 316

  Fly  1058 PNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNR----------HSGGFEYIVNADAVKLAD 1112
            |..|.||.|    |.|              .|.|:|.          .|||     .|.|.:..|
Mouse   317 PYLLKETSK----GGG--------------QGEDRNLLYYSKLGLVVPSGG-----PASANQSID 358

  Fly  1113 GSTPNVYTGRYDYVMKDLMSI--------------TNGGTLDDEEEEPGSVAKKMRLDDSSNNSS 1163
            .|.|.|.:     :::..:|:              ::.|:.....|.||||...|     |..||
Mouse   359 RSGPLVKS-----LLRRSLSMDSQVPVYSPSIDLKSSQGSSTAANEAPGSVFCSM-----SQKSS 413

  Fly  1164 LVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVN---AALAAANRMTPKSLTITATPATD 1225
            |       |:|....|:......|..|....::||.:.:   |:.....|:..:..:..:.|:..
Mouse   414 L-------KDCSEKKALDDRPQVLQPHRLRSFSASQSTDREEASPVTEVRIKTEPSSPLSDPSDI 471

  Fly  1226 SELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSY 1290
            ..:.|||..:.:|.|..|             .|...|.|....:...|.|.....:|||.
Mouse   472 IRVTVGGDAAAAAVAAAA-------------AAAATRDLPLKTEEDQRDMSRLPAKRRFQ----- 518

  Fly  1291 RYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSES 1355
                 ||.:                   ..||......||.|:.:|      .|:
Mouse   519 -----TDRR-------------------SPLKKAKANEHGPAVSEE------NCE---------- 543

  Fly  1356 ELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQC 1420
                           ...:..|..|...|              :||:....|....:.|...::|
Mouse   544 ---------------EGRSPPSLDSNFPD--------------SDLNREEFGELEGTRPNKKFKC 579

  Fly  1421 KYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRK 1485
            |:|...|.:...|..|:|.:.. ....|:|..|...:.....:|.|...:|..|.||:..|....
Mouse   580 KHCLKIFRSTAGLHRHVNMYHN-PEKPYACDICHKRFHTNFKVWTHCQTQHGIVKNPSPASSSHA 643

  Fly  1486 VF---FDRQMHDNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIF----RHKTGDDDDEEDDD 1543
            |.   |.|::.|                       :......|:.:.    |.|.| ...:....
Mouse   644 VLDEKFQRKLID-----------------------IVREREIKKALIIKLRRSKPG-FQGQSSSP 684

  Fly  1544 EQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQEL 1608
            .||.::....|...|..:                      |..||..:.....|.:||:.|..|
Mouse   685 AQQVIKRNLRSRAKGAYI----------------------CAYCGKAYRFLSQFKQHIKMHPGE- 726

  Fly  1609 YVDNPLAAMFDDGPADAGQFQVERQNENGE-YACDLCAKTFPQVIALKVHRKW------------ 1660
               .||.......|.:..   :.|..||.| |.|.||......::....|.:.
Mouse   727 ---RPLGVSRAAKPKERA---LARAVENKEVYPCRLCNAKLSSLLEQGNHERLCRNATVCPYCSL 785

  Fly  1661 -HFRGDSKQNPIDG-EATQLTNN-------------NHTTNNNNNNSMHLRELHAVGLM------ 1704
             .|....||...|. |..:||..             .|....:|.|:|.|.|..|:..:
Mouse   786 RFFSPALKQEHEDRCEYKKLTCLECMRTFKSSFSIWRHQVEVHNQNNMALAENFALATLDHNGEV 850

  Fly  1705 -----PNQQQQSLN-----------NSCNSSMNHNNNSSSNRSKSMKRKRELK------------ 1741
                 |..:...:|           :..:..:|.::..||...:.:...::||
Mouse   851 AAASRPQTEPSKVNHVATPKEDTAFSDSSEQVNFDSEDSSCLPEDLSLSKQLKVQVKEEPVEEAE 915

  Fly  1742 -----------------------CEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDDHLT 1783
                                   ||.|...|.::..|.||                     ..|.
Mouse   916 EEAPEASAAPREAGPSKETGLWPCEKCGKMFTAHKQLERH---------------------QELL 959

  Fly  1784 CRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHL--------- 1839
            |.                      |:||.     |.:|.:......:|.:|...|:
Mouse   960 CS----------------------VKPFI-----CHVCYKAFRTNFRLWSHFQTHMSQATEEPVQ 997

  Fly  1840 KEEVIVPVATKA 1851
            ||..:.||.|.:
Mouse   998 KESEVCPVPTNS 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	5/21 (24%)
		C2H2 Zn finger	1067..1088	CDD:275368	2/20 (10%)
		C2H2 Zn finger	1279..1298	CDD:275371	4/18 (22%)
		C2H2 Zn finger	1308..1325	CDD:275371	2/16 (13%)
		C2H2 Zn finger	1420..1440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1450..1468	CDD:275368	4/17 (24%)
Zbtb21	NP_780637.2	BTB_POZ_ZBTB21_ZNF295	40..151	CDD:349518
		SUF4-like	576..>629	CDD:411020	12/53 (23%)
		C2H2 Zn finger	579..600	CDD:411020	7/20 (35%)
		C2H2 Zn finger	579..600	CDD:275368	7/20 (35%)
		C2H2 Zn finger	608..629	CDD:411020	4/20 (20%)
		zf-C2H2	701..723	CDD:395048	6/43 (14%)
		C2H2 Zn finger	703..723	CDD:275370	6/19 (32%)
		zf_C2H2_6	776..803	CDD:408245	5/26 (19%)
		C2H2 Zn finger	939..959	CDD:275370	7/40 (18%)
		C2H2 Zn finger	967..988	CDD:275370	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100