DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and znf423

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	XP_002937417.2	Gene:	znf423 / 100491000	XenbaseID:	XB-GENE-490169	Length:	1289	Species:	Xenopus tropicalis

Alignment Length:	1442	Identity:	270/1442 - (18%)
Similarity:	455/1442 - (31%)	Gaps:	480/1442 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 DSKVASCRACSLQFSTRANARRHERNLH--------PNLFQLSTDSPHNTPITKPTPALAAALEM 634
            |..:.:|..|...|.:.|....| |..|        |. |.....||.:..|..||..:....::
Frog    65 DESIYTCDNCQQDFDSLAELTEH-RTQHCLGDGDDDPQ-FSWVPSSPSSKDIASPTQIIGDGCDL 127

  Fly   635 QRAAAAAATAEANRAAGAAGGNISTQKYRQVVMNAFIKCEGGGYDYDNPEQYRPLLTRDK----V 695
                          ..|...|                   |.|..|       |....||    :
Frog   128 --------------GIGEEEG-------------------GSGLPY-------PCQFCDKSFSRL 152

  Fly   696 EFIEQNDEFLEQYQTMTCRCCNKYFSTYKNFMAHVR-----KKYPQLPRNLCFNC-LKMNDSKAL 754
            .:::::::.........|..|::.|...::...|::     |||.      |..| ...:.|..|
Frog   153 SYLKRHEQIHSDKLPFKCTYCSRLFKHKRSRDRHIKLHTGDKKYH------CHECEAAFSRSDHL 211

  Fly   755 FISHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASG 819
            .| |||..:....|:.....||.::|                         ..:..:......:.
Frog   212 KI-HLKTHSSSKPFKCTVCKRGFSST-------------------------SSLQSHMQAHRKNK 250

  Fly   820 EVVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFC 884
            |.:|.   |:|..|        ...:.|..|.:.|....:...||..:|..:..|.:  :||..|
Frog   251 EYMTK---SDREMK--------KDDFMCDYCEETFSQTEDLEKHVMTRHPQLSEKAD--LQCIHC 302

  Fly   885 GLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSG 949
            ...|||......|.:::....:.:|..|..:..:    ::.|| .||                ..
Frog   303 PEVFADETSLLTHIDHVHANKKHKCPMCPEQFSS----VEEVY-CHL----------------DS 346

  Fly   950 MARSNSMEHSPGKRSLLGALGVGSSAEESRSSS---AAPPLTSTPKLAGGNQVGGGGSTSASAAA 1011
            ..:.:|..||.....:||::...|||....|:|   |:.|.::...:.|..:.|
Frog   347 HRQPDSSNHSISPDPVLGSVASMSSATPDSSASLERASTPDSTLKPIRGHKRTG----------- 400

  Fly  1012 AAQSSANR--DASAPKSQYFSRMPQVCPICGQQYNNYNNVLR-HMESKHPNKLPETYKCVRCGLG 1073
                |.:|  :.:.||..|      .||.|.::..|...||. |:::.|.:|..:.:.|..|...
Frog   401 ----SFDREDERNWPKITY------SCPYCSKRDFNSLAVLEIHLKTIHVDKPQQNHTCQICLDS 455

  Fly  1074 YPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGT 1138
            .|.:..|.||:..||   ||                             :.|.|....:||
Frog   456 LPTLYNLNEHVRKVH---KN-----------------------------HAYPMVQFSNIT---- 484

  Fly  1139 LDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAV-- 1201
                                            ...|..|..:|::...|..|:|..:...||.
Frog   485 --------------------------------AFHCNYCPEMFADINSLQEHIRVTHCGPNATTQ 517

  Fly  1202 ---NAAL---AAANRMTPKSLTITATPATDSELGVGGTMSESAPATPA----------------- 1243
               ||..   .:...:|..|||   .....:...||.:..||....|.
Frog   518 EGNNAFFCNQCSMGFLTESSLT---EHIQQTHCNVGSSKLESPVIQPTQSFMEVYSCPYCTNSPI 579

  Fly  1244 ----------------NVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRY 1292
                            |:|.|...::..||:.....::.::.:     |.|:|
Frog   580 FGSILKLTKHIKENHKNIPLANHKKSKSEQSPVSSDVEVSSPK-----RQRLC------------ 627

  Fly  1293 HMLTDHQVQNVQFIKCKLCNAEFA----YEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSS 1353
              :..:.|.|.:: .|..|:.:|:    ::..||.||          |:::::..|..|...:.|
Frog   628 --VNLNSVSNGEY-PCNQCDLKFSNFETFQTHLKSHL----------ELLLRKQSCPQCKEDFDS 679

  Fly  1354 ESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWY 1418
            :..|.|| .::|.:|:::.....|...:.   |.:||   ....|.|:.|...           |
Frog   680 QESLLQH-LTIHYMTTSTHYVCESCDKQF---SSVDD---LQKHLLDMHTFVL-----------Y 726

  Fly  1419 QCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPA---EC 1480
            .|..|...|::...:.:|:......:...|.|..|.  :..|:.:.:..:.||..:.|||   :|
Frog   727 HCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACN--WDFRREVDLQLHVKHSHLGNPAKSHKC 789

  Fly  1481 SLCRKVF---FDRQMH-DNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDDDEED 1541
            ..|.:.|   .:.|.| ..|:...|.| ..|...|...  .|..|...|..:|           |
Frog   790 IFCGETFSTEVELQCHITTHSKKYNCK-FCSKAFHAII--LLEKHLREKHCVF-----------D 840

  Fly  1542 DDEQQQLEERANSDGNGTTVGVASG---STAAAGTSLKIRIPEV------------------ACT 1585
            .:.|           |||..|:...   |.:|...|:.::.|:|                  .|.
Frog   841 TNNQ-----------NGTANGMVPANKKSESAEAQSVLMKNPDVTNSHEASEDDVDASEPMYGCD 894

  Fly  1586 ICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQ 1650
            ||||.:|.:.....|..:       |:.:....||......:|      ..|.:.|::|::||..
Frog   895 ICGAAYTMEVLLQNHRLR-------DHNIRPGEDDSSRKKAEF------IKGTHKCNICSRTFFS 946

  Fly  1651 VIALKVHRKWHFRGDSKQN--PIDGE--ATQLTNNNHTTNNNNNNSMHLRELHA----VGLMPNQ 1707
            ...|:.|.:.| ||.:|..  ||.||  .:.||...|...       |.:.|..    :..||.|
Frog   947 ENGLREHMQTH-RGPAKHYMCPICGERFPSLLTLTEHKVT-------HSKSLDTGTCRICKMPLQ 1003

  Fly  1708 QQQSLNNSCNSSMNHNN---------------------------------NSSSNRSKSMKRKRE 1739
            .::.....|....:..|                                 ||:::.......::.
Frog  1004 SEEEFIEHCQMHPDLRNSLTGFRCVVCMQTVTSTLELKIHGTFHMQKLAGNSAASSPNGQTLQKM 1068

  Fly  1740 LKCEYCASTFISNNNLRRHMYELHKHEVSNLP--------------EP----PVIVVD---DHLT 1783
            .||..|...|       |:..:|.|.:|:.||              :|    |....|   ..|.
Frog  1069 YKCALCLKEF-------RNKQDLVKLDVNGLPYGLCAGCLSRSTNGQPSNPTPQEACDRLCTSLR 1126

  Fly  1784 CRRCQLKFDTKE-----LWIEH-----------KLADAKVVRPFCPFQWGCDLCGEYLSRKEKLM 1832
            |..|.:||::.|     :.::|           |:|.:..|.....:|  |..|......:.::.
Frog  1127 CPECSVKFESAEDLESHVQMDHRDLAQDSSGQRKVAQSSPVPRKKTYQ--CIKCQMTFENEREIQ 1189

  Fly  1833 NHINNHLKEEVI 1844
            .|:.||:.||.|
Frog  1190 IHVANHMIEEGI 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	7/21 (33%)
		C2H2 Zn finger	1067..1088	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1279..1298	CDD:275371	1/18 (6%)
		C2H2 Zn finger	1308..1325	CDD:275371	5/20 (25%)
		C2H2 Zn finger	1420..1440	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1450..1468	CDD:275368	3/17 (18%)
znf423	XP_002937417.2	COG5048	<141..246	CDD:227381	22/136 (16%)
		C2H2 Zn finger	142..162	CDD:275368	2/19 (11%)
		C2H2 Zn finger	170..190	CDD:275368	4/19 (21%)
		COG5048	196..601	CDD:227381	101/562 (18%)
		C2H2 Zn finger	198..218	CDD:275368	8/20 (40%)
		C2H2 Zn finger	226..246	CDD:275368	3/44 (7%)
		C2H2 Zn finger	267..286	CDD:275368	5/18 (28%)
		C2H2 Zn finger	299..316	CDD:275368	5/16 (31%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	449..470	CDD:275368	6/20 (30%)
		C2H2 Zn finger	488..509	CDD:275368	6/20 (30%)
		C2H2 Zn finger	525..546	CDD:275368	4/23 (17%)
		C2H2 Zn finger	640..660	CDD:275368	5/19 (26%)
		C2H2 Zn finger	670..690	CDD:275368	6/20 (30%)
		C2H2 Zn finger	700..717	CDD:275368	4/22 (18%)
		C2H2 Zn finger	728..749	CDD:275368	4/20 (20%)
		C2H2 Zn finger	758..779	CDD:275368	5/22 (23%)
		C2H2 Zn finger	789..809	CDD:275368	5/19 (26%)
		C2H2 Zn finger	815..833	CDD:275368	5/20 (25%)
		C2H2 Zn finger	893..914	CDD:275368	7/27 (26%)
		C2H2 Zn finger	937..957	CDD:275368	6/19 (32%)
		C2H2 Zn finger	966..986	CDD:275368	7/26 (27%)
		C2H2 Zn finger	1205..1225	CDD:275368
		C2H2 Zn finger	1236..1257	CDD:275368
		C2H2 Zn finger	1266..1282	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100