DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and ZNF316

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	NP_001265488.1	Gene:	ZNF316 / 100131017	HGNCID:	13843	Length:	1004	Species:	Homo sapiens

Alignment Length:	1086	Identity:	192/1086 - (17%)
Similarity:	293/1086 - (26%)	Gaps:	450/1086 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   913 DAKLETHQRFLDHVYQDH---------------LGGVGGGAVSDNAST-TGSGMARSNSMEHSPG 961
            |.:.|..:.||..|.::.               :.|..|...||:|.| .|.|        ..||
Human   246 DHEEEDDEDFLAEVAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSAQTPEGWG--------PDPG 302

  Fly   962 KRSLLGALGVGSSAEE---------------SRSSSAAPPL---TSTPKLAG------------- 995
            .   ||.|..||.|:.               :..::.|||.   .:|..:.|
Human   303 G---LGVLADGSEAKPFLPGREPGANLLSPWAFPAAVAPPAGRPETTCDVCGKVFPHRSRLAKHQ 364

  Fly   996 ---------GNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLR 1051
                     |.:..|.|....|..|..|.:           :....|..||.||:::...::::.
Human   365 RYHAAVKPFGCEECGKGFVYRSHLAIHQRT-----------HTGEKPFPCPDCGKRFVYKSHLVT 418

  Fly  1052 HMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTP 1116
            |... |..:.|  |:|..||.|:.|.|||..|        :..|:|...|              |
Human   419 HRRI-HTGERP--YRCAFCGAGFGRRSYLVTH--------QRTHTGERPY--------------P 458

  Fly  1117 NVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSL-----VGVASQQKECPI 1176
            ..:.||                                  ..|.:|:|     |..|.:...||.
Human   459 CSHCGR----------------------------------SFSQSSALARHQAVHTADRPHCCPD 489

  Fly  1177 CNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELG-----VGGTMSE 1236
            |...|........|.|....|.     |.....|..|......|.| .|::.|     ||....|
Human   490 CGQAFRLRADFQRHRRGGGCAE-----AGGDGPRREPGETAAAAGP-EDTDPGPEGSEVGEADGE 548

  Fly  1237 SAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQ 1301
            :..|.......|:|..||..:      :|.|.:|||..:...:.:....|.....:|
Human   549 AEAAAEEREEAAVAAPTPSGK------VDPAPERRFLELGNGLGEGEGPSSHPLGFH-------- 599

  Fly  1302 NVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHK 1366
                                    |.||.|
Human   600 ------------------------FPVHPK----------------------------------- 605

  Fly  1367 LTSASASTSASTSSKIDDDS------------LMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQ 1419
                         |.:..||            |..||:|..:.|....:|..|...|..|.....
Human   606 -------------SWLHPDSFPILGLPDFRERLPVDGRPLPAPLGGPLSLVEGTGLACDPFGGGG 657

  Fly  1420 C--------KYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPN 1476
            .        .:.|:......:.|....:.:|   :.:.|.|||..:..|.:|..|  :::.....
Human   658 AAGGGGGLRAFGPAIGGLLAEPAPAALAEEE---SPWICSDCGKTFGRRAALAKH--QRYHAGER 717

  Fly  1477 PAECSLCRKVFF-------DRQMHDNHTPTCNRKPITSTGAHQQQDGQLHSH---HTAKRTIFRH 1531
            |..|:.|.|.|.       .|:.|....|.    |....||...:...|.:|   ||.::..
Human   718 PHRCADCGKSFVYGSHLARHRRTHTGERPF----PCPECGARFARGSHLAAHVRGHTGEKPF--- 775

  Fly  1532 KTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARFTDQEH 1596
                                                               .|.:|||.|:.:.|
Human   776 ---------------------------------------------------VCGVCGAGFSRRAH 789

  Fly  1597 FSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWH 1661
            .:.|.:.|..|    .|                         |||..|.:.|.|..||..|:..|
Human   790 LTAHGRAHTGE----RP-------------------------YACGECGRRFGQSAALTRHQWAH 825

  Fly  1662 FRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNS 1726
            ......:.|                                            .|.....|:::.
Human   826 AEEKPHRCP--------------------------------------------DCGKGFGHSSDF 846

  Fly  1727 SSNRSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKF 1791
            ..:| ::...::..:|..|...|...:||.:|    .:......|.|          |..|..:|
Human   847 KRHR-RTHTGEKPFRCADCGRGFAQRSNLAKH----RRGHTGERPFP----------CPECGKRF 896

  Fly  1792 DTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHLKEEVIVPVATKAAIERT 1856
            ..:.:.:.|:..... .||:     .|..||...|:...|:.|:..|           :.|   |
Human   897 SQRSVLVTHQRTHTG-ERPY-----ACANCGRRFSQSSHLLTHMKTH-----------RGA---T 941

  Fly  1857 AAMESAAADA------NAAATLSALGEGAETEDQFAEKVEAAGATT 1896
            ||..|.:|.|      .||...|:.|.|    ::.:..:|.||.|:
Human   942 AAPGSGSAPAPAPKPEAAAKGPSSAGPG----ERGSALLEFAGGTS 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1067..1088	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1279..1298	CDD:275371	2/18 (11%)
		C2H2 Zn finger	1308..1325	CDD:275371	0/16 (0%)
		C2H2 Zn finger	1420..1440	CDD:275368	2/27 (7%)
		C2H2 Zn finger	1450..1468	CDD:275368	7/17 (41%)
ZNF316	NP_001265488.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..148
		KRAB	158..218	CDD:214630
		COG5048	<345..503	CDD:227381	41/227 (18%)
		C2H2 Zn finger	347..367	CDD:275368	1/19 (5%)
		C2H2 Zn finger	375..395	CDD:275368	5/30 (17%)
		C2H2 Zn finger	403..423	CDD:275368	5/20 (25%)
		C2H2 Zn finger	431..451	CDD:275368	9/27 (33%)
		C2H2 Zn finger	459..479	CDD:275368	5/53 (9%)
		C2H2 Zn finger	487..505	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..574		17/77 (22%)
		C2H2 Zn finger	693..713	CDD:275368	7/21 (33%)
		zf-H2C2_2	705..730	CDD:316026	7/26 (27%)
		C2H2 Zn finger	721..741	CDD:275368	5/19 (26%)
		COG5048	<746..933	CDD:227381	51/338 (15%)
		C2H2 Zn finger	749..769	CDD:275368	4/19 (21%)
		C2H2 Zn finger	777..797	CDD:275368	7/19 (37%)
		C2H2 Zn finger	805..825	CDD:275368	7/19 (37%)
		C2H2 Zn finger	833..853	CDD:275368	4/64 (6%)
		C2H2 Zn finger	861..881	CDD:275368	6/23 (26%)
		C2H2 Zn finger	889..909	CDD:275368	4/19 (21%)
		C2H2 Zn finger	917..937	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	936..976		13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100