DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hang and si:ch211-202h22.10

DIOPT Version :9

Sequence 1:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster
Sequence 2:	XP_017212100.2	Gene:	si:ch211-202h22.10 / 100002322	ZFINID:	ZDB-GENE-110914-121	Length:	519	Species:	Danio rerio

Alignment Length:	686	Identity:	134/686 - (19%)
Similarity:	218/686 - (31%)	Gaps:	218/686 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1033 PQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSG 1097
            |.:||.||:.::....:..|:.. |..:.|  :.|.:||.|:.:...::.||
Zfish     9 PFICPECGKCFSAKQKLETHIRI-HTGEKP--FSCPQCGKGFTQQGQIKTHM------------- 57

  Fly  1098 GFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNS 1162
                               .::||...:....         .|.......|:...||
Zfish    58 -------------------RIHTGEKPFTCPQ---------CDKSVTSKQSLKSHMR-------- 86

  Fly  1163 SLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLT------ITAT 1221
              :....:...||.|..:||....|..|:|:| |.....:...........:||.      ....
Zfish    87 --IHTGEKPFTCPECGMIFSQLGYLKRHVRTH-TGLKPFSCTQCGKRYKVKQSLESHMRVHTGEK 148

  Fly  1222 PATDSELGVGGT--------MSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCR 1278
            |....:.|.|.|        ||......|.|                                |.
Zfish   149 PFACPQCGKGFTAKQCLKSHMSVHIEEKPFN--------------------------------CS 181

  Fly  1279 ICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVH-GKAIKDEMIIKQF 1342
            :|:..|:.::|.:.|||.  .|....:: |:.|...|:.::.|:.|: ::| |:        |.|
Zfish   182 LCEMSFTHQQSLKRHMLI--HVGEKPYV-CRQCGKSFSVKQSLESHI-RIHTGE--------KPF 234

  Fly  1343 ECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGK--PTSSDLADLSTLA 1405
            .|..|...::.:..|:.|.| ||              :.:...|....||  .....|....|:
Zfish   235 ACAECGKGFAVKQNLESHMR-VH--------------TGVKPFSCPQCGKRFTVKQSLESHMTI- 283

  Fly  1406 AGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKK 1470
               .|...|   :.|..|...|....||..|:.:|.  ....|.|..|||.|:.|..|     ::
Zfish   284 ---HTGERP---FTCSMCDKTFTVKHKLEYHMRNHT--GEKPYICPQCGNSYALRNHL-----ER 335

  Fly  1471 HPQV---PNPAECSLCRKVFFDRQMHDNHTPTCNR-KP--ITSTGAHQQQDGQLHSH---HTAKR 1526
            |.::   ..|..||.|.|.|..:|...:|....|| ||  .:..|........|.||   ||.::
Zfish   336 HVRIHTGEKPFSCSKCAKRFTMKQSLKSHMRVHNRTKPYICSQCGKRFTVKQSLESHMSLHTGEK 400

  Fly  1527 TIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARF 1591
            .....:.|     :....:|.||         |.:.|.:|...            .:|:.||..|
Zfish   401 PFTCTECG-----KSYTLRQSLE---------THMRVHTGDKC------------FSCSDCGRSF 439

  Fly  1592 TDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGE--YACDLCAKTFPQVIAL 1654
            |.:::...|::.|                               .||  |.|..|.|.|.|...|
Zfish   440 TVKQNLHVHMRVH-------------------------------TGERPYTCAQCGKRFTQHGQL 473

  Fly  1655 KVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNN 1690
            ..|.:.|     .:.....:.::.|.|:.|.:|:::
Zfish   474 NRHMRIH-----TEQKTTRDRSEETLNDETADNSSD 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1067..1088	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1279..1298	CDD:275371	6/18 (33%)
		C2H2 Zn finger	1308..1325	CDD:275371	4/16 (25%)
		C2H2 Zn finger	1420..1440	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1450..1468	CDD:275368	7/17 (41%)
si:ch211-202h22.10	XP_017212100.2	C2H2 Zn finger	12..32	CDD:275368	5/20 (25%)
		COG5048	36..439	CDD:227381	108/555 (19%)
		C2H2 Zn finger	40..60	CDD:275368	6/51 (12%)
		C2H2 Zn finger	68..88	CDD:275368	4/38 (11%)
		C2H2 Zn finger	96..116	CDD:275368	8/19 (42%)
		C2H2 Zn finger	124..144	CDD:275368	2/19 (11%)
		C2H2 Zn finger	152..172	CDD:275368	5/19 (26%)
		C2H2 Zn finger	180..200	CDD:275368	7/21 (33%)
		C2H2 Zn finger	208..228	CDD:275368	5/20 (25%)
		C2H2 Zn finger	236..256	CDD:275368	5/20 (25%)
		C2H2 Zn finger	264..284	CDD:275368	4/23 (17%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	8/24 (33%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..396	CDD:275368	4/19 (21%)
		C2H2 Zn finger	404..424	CDD:275368	5/33 (15%)
		C2H2 Zn finger	432..452	CDD:275368	6/19 (32%)
		zf-H2C2_2	448..469	CDD:316026	9/51 (18%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24408
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100