Protein Alignment rumi and POGLUT2

DIOPT Version :10

• Sequence 1: NP_651095.1
• Gene: rumi / 326122
• FlyBaseID: FBgn0086253
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_076994.2
• Gene: POGLUT2 / 79070
• HGNCID: 19350
• Length: 502
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 113/400 - (28%)
• Similarity: 180/400 - (45%)
• Gaps: 66/400 - (16%)

  Fly    54 IEKANADYKPCSSDPQDS-----DCSCHANV--LKRDLAPYKSTGVTRQMIESSARYGTKY---- 107
            |.|....::.|....|||     :.:|...:  ::||||.:.:....:..:|...|:|.:.
Human   127 ILKGPVYHENCDCPLQDSAAWLREMNCPETIAQIQRDLAHFPAVDPEKIAVEIPKRFGQRQSLCH 191

  Fly   108 ------KIY--------GHRLYRDANCMFPARCEGIEHFLLPLV--ATLPDMDLIINTRDYPQLN 156
                  |:|        |.|::.||             .||.|.  ..:||::|.:|..|:| |.
Human   192 YTLKDNKVYIKTHGEHVGFRIFMDA-------------ILLSLTRKVKMPDVELFVNLGDWP-LE 242

  Fly   157 AAWGNAAGGPVFSFSKTKEYRDIMYPAWTFWAGGPATKLHPRGIGRWDQMREKLEKRAAAIPWSQ 221
            ....|:...|:||:..:.:.:||:.|.:..    ..:.|...|....|.|..:..   ...||..
Human   243 KKKSNSNIHPIFSWCGSTDSKDIVMPTYDL----TDSVLETMGRVSLDMMSVQAN---TGPPWES 300

  Fly   222 KRSLGFFRGSRTSDERDSLILLSRRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFEDHCKYKY 286
            |.|...:||..:..||..|:.|||::|||::|.:| |..:....:.|..|....:||.|..|:||
Human   301 KNSTAVWRGRDSRKERLELVKLSRKHPELIDAAFT-NFFFFKHDENLYGPIVKHISFFDFFKHKY 364

  Fly   287 LFNFRGVAASFRLKHLFLCKSLVFHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQEYEHILSFFKK 351
            ..|..|..|::||.:|.:..|:|......:.|.||::|:||.||:|:||  :..:....|.:.|.
Human   365 QINIDGTVAAYRLPYLLVGDSVVLKQDSIYYEHFYNELQPWKHYIPVKS--NLSDLLEKLKWAKD 427

  Fly   352 NDALAQEIAQRGYDFIWEHLRMKDIKCYWRKLLKRYVKLLQYE---------VKP--EDQLI--- 402
            :|..|::||:.|.:|...:|...||.||:.||.:.|..|...|         |:|  ||.|.
Human   428 HDEEAKKIAKAGQEFARNNLMGDDIFCYYFKLFQEYANLQVSEPQIREGMKRVEPQTEDDLFPCT 492

  Fly   403 -YIGPKKDEL 411
             :....||||
Human   493 CHRKKTKDEL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rumi	NP_651095.1	CAP10	139..394	CDD:214773	80/254 (31%)
POGLUT2	NP_076994.2	Filamin	24..130		1/2 (50%)
		IG_FLMN	29..129	CDD:214720	1/1 (100%)
		Glyco_transf_90	151..484	CDD:310354	100/356 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	499..502		2/2 (100%)