DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rumi and Poglut2

DIOPT Version :9

Sequence 1:	NP_651095.1	Gene:	rumi / 326122	FlyBaseID:	FBgn0086253	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_076134.1	Gene:	Poglut2 / 72050	MGIID:	1919300	Length:	502	Species:	Mus musculus

Alignment Length:	391	Identity:	106/391 - (27%)
Similarity:	181/391 - (46%)	Gaps:	52/391 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EFSFKIRRQIEKANADYKPCSSDP-----QDSDCSCHANVLKRDLAPYKSTGVTRQMIESSARYG 104
            |..:.:|..:...|.|   |..:.     ::.:||...:.:::|||.:.:....:...|...|:|
Mouse   123 ESPYVLRGPVYHENCD---CPLEDSAAWLREMNCSETISQIQKDLAHFPTVDPEKIAAEIPKRFG 184

  Fly   105 TKY----------KIY--------GHRLYRDANCMFPARCEGIEHFLLPLV--ATLPDMDLIINT 149
            .:.          |:|        |.|::.||             .||.|.  ..:||::..:|.
Mouse   185 QRQSLCHYTLKDNKVYIKTHGEHVGFRIFMDA-------------ILLSLTRKVRMPDVEFFVNL 236

  Fly   150 RDYPQLNAAWGNAAGGPVFSFSKTKEYRDIMYPAWTFWAGGPATKLHPRGIGRWDQMREKLEKRA 214
            .|:| |.....|:...|:||:..:.|.|||:.|.:..    ..:.|...|....|.|..:..
Mouse   237 GDWP-LEKKKSNSNIQPIFSWCGSTESRDIVMPTYDL----TDSVLETMGRVSLDMMSVQAN--- 293

  Fly   215 AAIPWSQKRSLGFFRGSRTSDERDSLILLSRRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFE 279
            ...||..|.|...:||..:..||..|:.|||::|||::|.:| |..:....::|..|....:||.
Mouse   294 TGPPWESKNSTAVWRGRDSRKERLELVKLSRKHPELIDAAFT-NFFFFKHDESLYGPIVKHISFF 357

  Fly   280 DHCKYKYLFNFRGVAASFRLKHLFLCKSLVFHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQEYEH 344
            |..|:||..|..|..|::||.:|.:..|:|......:.|.||::|:||.||:|:||  :..:...
Mouse   358 DFFKHKYQINIDGTVAAYRLPYLLVGDSVVLKQDSIYYEHFYNELQPWKHYIPVKS--NLSDLLE 420

  Fly   345 ILSFFKKNDALAQEIAQRGYDFIWEHLRMKDIKCYWRKLLKRYVKLLQYEVKPEDQLIYIGPKKD 409
            .|.:.|::||.|::||:.|.:|...:|...||.||:.||.:.|..|...|.:..:.:..:.|:.:
Mouse   421 KLKWAKEHDAEAKKIAKAGQEFARNNLMGDDIFCYYFKLFQGYANLQVSEPQIREGMKRVEPQSE 485

  Fly   410 E 410
            :
Mouse   486 D 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rumi	NP_651095.1	CAP10	139..394	CDD:214773	82/254 (32%)
Poglut2	NP_076134.1	Filamin	24..130		1/6 (17%)
		Filamin	28..127	CDD:279024	1/3 (33%)
		IG_FLMN	29..129	CDD:214720	1/5 (20%)
		Glyco_transf_90	151..484	CDD:283366	101/356 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	499..502
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2458
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810