DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rumi and poglut2

DIOPT Version :9

Sequence 1:	NP_651095.1	Gene:	rumi / 326122	FlyBaseID:	FBgn0086253	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_957225.1	Gene:	poglut2 / 393905	ZFINID:	ZDB-GENE-040426-878	Length:	500	Species:	Danio rerio

Alignment Length:	457	Identity:	113/457 - (24%)
Similarity:	191/457 - (41%)	Gaps:	81/457 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ISLVGTGGAEDDGLCSADQKSCAQSEP------DQINEDEFSFKIRRQIEKANAD---------- 60
            :...||......|..:.:.|..:.:||      ..::.::.||.:|.::..:..|
Zfish    54 VDTTGTNFTTSPGENTFEVKITSPTEPYARIWIQILDRNDGSFLVRYRMYASYTDLHVEVLLKDK 118

  Fly    61 --------------YKPCSSDPQDS-------DCSCHANVLKRDLAPYKSTGVTRQMIESSARYG 104
                          ::.|.....|.       .|....:.::.||:.::|....|...|...|:|
Zfish   119 LVGKSPYVLRGAVYHESCDCPEPDGALWEKNMHCPASFSQIESDLSIFQSVDPDRNAHEIIQRFG 183

  Fly   105 TKY----------KIY--------GHRLYRDANCMFPARCEGIEHFLLPLV--ATLPDMDLIINT 149
            ..:          ::|        |.|::.||             |||.|.  ..|||::..:|.
Zfish   184 KSHSLCHYTIKNNQVYIKTHGEHVGFRIFMDA-------------FLLSLTRKVKLPDIEFFVNL 235

  Fly   150 RDYPQLNAAWGNAAGGPVFSFSKTKEYRDIMYPAWTFWAGGPATKLHPRGIGRWDQMREKLEKRA 214
            .|:| |.....:....||||:..:.:.|||:.|.:..    ..:.|...|....|.|  .::...
Zfish   236 GDWP-LEKRRASQNPSPVFSWCGSNDTRDIVMPTYDL----TESVLETMGRVSLDMM--SVQGHT 293

  Fly   215 AAIPWSQKRSLGFFRGSRTSDERDSLILLSRRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFE 279
            ..: |.:|.:.||:||..:..||..|:.|:|.|..:::|..| |..:....::|..|....|||.
Zfish   294 GPV-WEKKINKGFWRGRDSRKERLELVKLARANTAMLDAALT-NFFFFKHDESLYGPLVKHVSFF 356

  Fly   280 DHCKYKYLFNFRGVAASFRLKHLFLCKSLVFHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQEYEH 344
            |..||||..|..|..|::||.:|....|:||.....:.|.||::|:|||||:|.:|  ...:...
Zfish   357 DFFKYKYQINVDGTVAAYRLPYLLAGDSVVFKHDSIYYEHFYNELQPWVHYIPFRS--DLSDLLE 419

  Fly   345 ILSFFKKNDALAQEIAQRGYDFIWEHLRMKDIKCYWRKLLKRYVKLLQYEVKPEDQLIYIGPKKD 409
            .:.:.|.:|..|::||..|..|...||....:.||:.||.::|.:|...:.|..|.:..:...||
Zfish   420 KIQWAKDHDEEAKKIALAGQQFARTHLMGDSVFCYYHKLFQKYAELQVTKPKVRDGMELVEQPKD 484

  Fly   410 EL 411
            :|
Zfish   485 DL 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rumi	NP_651095.1	CAP10	139..394	CDD:214773	79/254 (31%)
poglut2	NP_957225.1	Filamin	23..128		10/73 (14%)
		Filamin	33..126	CDD:279024	10/71 (14%)
		Glyco_transf_90	147..500	CDD:283366	101/364 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	497..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2458
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810