DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rumi and Poglut3

DIOPT Version :9

Sequence 1:	NP_651095.1	Gene:	rumi / 326122	FlyBaseID:	FBgn0086253	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001020294.3	Gene:	Poglut3 / 315664	RGDID:	1562027	Length:	508	Species:	Rattus norvegicus

Alignment Length:	382	Identity:	104/382 - (27%)
Similarity:	175/382 - (45%)	Gaps:	42/382 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DYKPC-SSDPQ--DSDCSCHAN--VLKRDLAPYKSTGVTRQMIESSARYGTK------YKIYGHR 113
            :|..| ..|||  ....||.||  .:::|...:.|..:.:.:.|...|:|.:      |.|..:.
  Rat   139 EYCDCPEDDPQAWQKTLSCPANEPQIEQDFISFPSINLQQMLKEVPKRFGDERGAIVHYTILNNH 203

  Fly   114 LYRDANCMFPARCEGIEHFLLPLV--ATLPDMDLIINTRDYPQLNAAWGNAAGG-PVFSFSKTKE 175
            :||.:...:.......:..||.|.  .||||::..||..|:|..:....:..|. |:.|:..:.:
  Rat   204 IYRRSLGKYTDFKMFSDEILLSLARKVTLPDLEFYINLGDWPLEHRKVNDTPGPIPIISWCGSLD 268

  Fly   176 YRDIMYPAWTFWAGGPATKLHPRGIGRWDQMREKLEKRAAAIP-WSQKRSLGFFRGSRTSDERDS 239
            .|||:.|.:..   ..:|....||:     ..:.|..:....| |..|....||||..:.:||..
  Rat   269 SRDIILPTYDV---THSTLEAMRGV-----TNDLLSVQGNTGPSWINKTEKAFFRGRDSREERLQ 325

  Fly   240 LILLSRRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFEDHCKYKYLFNFRGVAASFRLKHLFL 304
            |:|||:.||:|::|..|....::..:..|.  .|..:.|.|..||||..|..|..|::|..:|.|
  Rat   326 LVLLSKENPQLLDAGITGYFFFQEKEKELG--KAKLMGFFDFFKYKYQVNVDGTVAAYRYPYLML 388

  Fly   305 CKSLVFHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQEYEHILSFFKKNDALAQEIAQRGYDFIWE 369
            ..|||......:.|.||.:|:||.||||:|.  :..:....:.:.|:||..|:.||:.|.....:
  Rat   389 GDSLVLKQESPYYEHFYVELRPWKHYVPIKR--NLSDLLEKVKWAKENDEEAKRIAKEGQLTARD 451

  Fly   370 HLRMKDIKCYWRKLLKRYVKL----------LQYEVKPED-----QLIYIGPKKDEL 411
            .|:...:.||:.::|::|.:.          ::...:|:|     |.....|:::||
  Rat   452 LLQPPRLYCYYYRVLQKYAERQVSKPMIRDGMERVPQPDDSTSVRQCHRKRPEREEL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rumi	NP_651095.1	CAP10	139..394	CDD:214773	77/266 (29%)
Poglut3	NP_001020294.3	Filamin	25..134
		Filamin	27..131	CDD:279024
		IG_FLMN	29..133	CDD:214720
		Glyco_transf_90	152..486	CDD:304992	93/345 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..508		4/27 (15%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	505..508		0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2458
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810