DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rumi and Poglut1

DIOPT Version :9

Sequence 1:	NP_651095.1	Gene:	rumi / 326122	FlyBaseID:	FBgn0086253	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_759012.1	Gene:	Poglut1 / 224143	MGIID:	2444232	Length:	392	Species:	Mus musculus

Alignment Length:	364	Identity:	208/364 - (57%)
Similarity:	255/364 - (70%)	Gaps:	14/364 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 QIEKANADYKPCSSDPQDSDCSCHANVLKRDLAPYKSTGVTRQMIESSAR--YGTKYKIYGHRLY 115
            ||.:|..:|:||||    .:|||:..|::.||.|::. |::|:|:....|  .||.|:|..:||:
Mouse    38 QINRALENYEPCSS----QNCSCYHGVIEEDLTPFRG-GISRKMMAEVVRRKLGTHYQIIKNRLF 97

  Fly   116 RDANCMFPARCEGIEHFLLPLVATLPDMDLIINTRDYPQLNAAWGNAAGGPVFSFSKTKEYRDIM 180
            |:.:||||:||.|:|||:|.::..||||:::||.|||||: ..|.... .||||||||.||.|||
Mouse    98 REDDCMFPSRCSGVEHFILEVIHRLPDMEMVINVRDYPQV-PKWMEPT-IPVFSFSKTSEYHDIM 160

  Fly   181 YPAWTFWAGGPAT-KLHPRGIGRWDQMREKLEKRAAAIPWSQKRSLGFFRGSRTSDERDSLILLS 244
            |||||||.||||. .|:|.|:||||..||.|.:.||..||.:|.|..:|||||||.|||.|||||
Mouse   161 YPAWTFWEGGPAVWPLYPTGLGRWDLFREDLLRSAAQWPWEKKNSTAYFRGSRTSPERDPLILLS 225

  Fly   245 RRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFEDHCKYKYLFNFRGVAASFRLKHLFLCKSLV 309
            |:||:||:|:|||||.|||.||||..|||.:|...|||||:|||||||||||||.||||||.|||
Mouse   226 RKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLIDHCKYRYLFNFRGVAASFRFKHLFLCGSLV 290

  Fly   310 FHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQEYEHILSFFKKNDALAQEIAQRGYDFIWEHLRMK 374
            |||||||.||||.||||||||:|:|:  .....:.:|.|.|.||.:|||||:||..||..||:|.
Mouse   291 FHVGDEWVEFFYPQLKPWVHYIPVKT--DLSNVQELLQFVKANDDIAQEIAKRGSQFIINHLQMD 353

  Fly   375 DIKCYWRKLLKRYVKLLQYEVKPEDQLIYIGPK--KDEL 411
            ||.|||..||..|.|.|.|.|........|.|:  |.||
Mouse   354 DITCYWENLLTDYSKFLSYNVTRRKDYYQIVPRRLKTEL 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rumi	NP_651095.1	CAP10	139..394	CDD:214773	164/255 (64%)
Poglut1	NP_759012.1	Glyco_transf_90	49..388	CDD:283366	200/347 (58%)
		Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates. /evidence=ECO:0000250\|UniProtKB:Q8NBL1	103..107		3/3 (100%)
		Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates. /evidence=ECO:0000250\|UniProtKB:Q8NBL1	172..178		2/5 (40%)
		UDP-glucose binding. /evidence=ECO:0000250\|UniProtKB:Q8NBL1	274..279		4/4 (100%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	389..392		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849229
Domainoid	1	1.000	404	1.000	Domainoid score	I719
eggNOG	1	0.900	-	-		E1_KOG2458
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41353
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1797
Isobase	1	0.950	-	0	Normalized mean entropy	S5512
OMA	1	1.010	-	-		QHG59845
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007017
OrthoInspector	1	1.000	-	-		oto95254
orthoMCL	1	0.900	-	-		OOG6_103472
Panther	1	1.100	-	-	LDO	PTHR12203
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4743
SonicParanoid	1	1.000	-	-		X5899
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740