DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rumi and POGLUT3

DIOPT Version :9

Sequence 1:	NP_651095.1	Gene:	rumi / 326122	FlyBaseID:	FBgn0086253	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_714916.3	Gene:	POGLUT3 / 143888	HGNCID:	28496	Length:	507	Species:	Homo sapiens

Alignment Length:	361	Identity:	96/361 - (26%)
Similarity:	162/361 - (44%)	Gaps:	44/361 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DYKPCSSDPQ----DSDCSCHANVLKRDLAPYKSTGVTRQMIESSARYGTK------YKIYGHRL 114
            :|..|..|||    ...|......:.:|.|.:.|..:.:.:.|...|:|.:      |.|..:.:
Human   139 EYCECPEDPQAWQKTLSCPTKEPQIAKDFASFPSINLQQMLKEVPKRFGDERGAIVHYTILNNHV 203

  Fly   115 YRDANCMFPARCEGIEHFLLPLV--ATLPDMDLIINTRDYP----QLNAAWGNAAGGPVFSFSKT 173
            ||.:...:.......:..||.|.  ..|||::..:|..|:|    ::|   |..:..|:.|:..:
Human   204 YRRSLGKYTDFKMFSDEILLSLTRKVLLPDLEFYVNLGDWPLEHRKVN---GTPSPIPIISWCGS 265

  Fly   174 KEYRDIMYPAWTFWAGGPATKLHP-----RGIGRWDQMREKLEKRAAAIP-WSQKRSLGFFRGSR 232
            .:.||::.|.:..        .|.     ||:     ..:.|..:....| |..|....||||..
Human   266 LDSRDVVLPTYDI--------THSMLEAMRGV-----TNDLLSIQGNTGPSWINKTERAFFRGRD 317

  Fly   233 TSDERDSLILLSRRNPELVEAQYTKNQGWKSPKDTLDAPAADEVSFEDHCKYKYLFNFRGVAASF 297
            :.:||..|:.||:.||:|::|..|....::..:..|.  .|..:.|.|..||||..|..|..|::
Human   318 SREERLQLVQLSKENPQLLDAGITGYFFFQEKEKELG--KAKLMGFFDFFKYKYQVNVDGTVAAY 380

  Fly   298 RLKHLFLCKSLVFHVGDEWQEFFYDQLKPWVHYVPLKSYPSQQEYEHILSFFKKNDALAQEIAQR 362
            |..:|.|..|||......:.|.||..|:||.||||:|.  :..:....:.:.|:||..|::||:.
Human   381 RYPYLMLGDSLVLKQDSPYYEHFYMALEPWKHYVPIKR--NLSDLLEKVKWAKENDEEAKKIAKE 443

  Fly   363 GYDFIWEHLRMKDIKCYWRKLLKRYVKLLQYEVKPE 398
            |.....:.|:...:.||:.::|::|.:  :...|||
Human   444 GQLMARDLLQPHRLYCYYYQVLQKYAE--RQSSKPE 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rumi	NP_651095.1	CAP10	139..394	CDD:214773	74/264 (28%)
POGLUT3	NP_714916.3	Filamin	24..134
		Filamin	27..131	CDD:279024
		IG_FLMN	29..133	CDD:214720
		Glyco_transf_90	151..485	CDD:304992	91/349 (26%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	504..507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2458
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810