DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC11 and HDAC9

DIOPT Version :9

Sequence 1:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_848512.1	Gene:	HDAC9 / 9734	HGNCID:	14065	Length:	1069	Species:	Homo sapiens

Alignment Length:	374	Identity:	86/374 - (22%)
Similarity:	140/374 - (37%)	Gaps:	98/374 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HHEEQESEEVVW-----------VKRDDARSAG--KLPIVFSRNYAVRFGGLERLHPFDAAK--- 57
            |.|.....:.:|           .:|...|.|.  ::.:|.|.::::.:|    .:|.|..|
Human   657 HPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYG----TNPLDGQKLDP 717

  Fly    58 --------GKHIHKLLCAQLQLDDGSFYEPTELTKDQLRRIHTREYLKSLRWSMNVACIAEVPLM 114
                    .|....|.|..|.:|..:.:  .||......|             |.|.|:.|:
Human   718 RILLGDDSQKFFSSLPCGGLGVDSDTIW--NELHSSGAAR-------------MAVGCVIEL--- 764

  Fly   115 AFVPNRYIQRSYLRPMRFQAAGSILAGKLALDYGWAINLGGGFHHCCSYRGGGFCPYADISLLIV 179
                                |..:.:|:  |..|:|:....| ||.......|||.:..:::...
Human   765 --------------------ASKVASGE--LKNGFAVVRPPG-HHAEESTAMGFCFFNSVAITAK 806

  Fly   180 RLFEQEPFRVRRIMIVDLDAHQGNGHERDF-NNVAAVYI----FDMYNAFVYPRDHVAKE----- 234
            .|.:|  ..:.:|:|||||.|.|||.::.| .:.:.:||    :|..|.|  |......|
Human   807 YLRDQ--LNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFF--PGSGAPNEVGTGL 867

  Fly   235 ------SIRCAVELRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEG--DPLGNLAIS 291
                  :|.....|.....|..||...:..:.....||.||||:.:||.|.|||  .|||...::
Human   868 GEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932

  Fly   292 AE--GVIERDRLVFSTFRALGIPVVMLLSGGYLKASAGVITDSIVNLRL 338
            |:  |.:.:..:..:..|     ||:.|.||:...:....:::.||..|
Human   933 AKCFGHLTKQLMTLADGR-----VVLALEGGHDLTAICDASEACVNALL 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	75/315 (24%)
HDAC9	NP_848512.1	Interaction with CTBP1. /evidence=ECO:0000250	23..27
		ClassIIa_HDAC9_Gln-rich-N	38..127	CDD:197399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142
		Interaction with MEF2. /evidence=ECO:0000250	139..157
		Interaction with MAPK10. /evidence=ECO:0000250	178..346
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..252
		Interaction with ETV6. /evidence=ECO:0000269\|PubMed:12590135	221..264
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..307
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..539
		HDAC_classIIa	634..1011	CDD:212544	86/374 (23%)
		Histone deacetylase	634..981		86/374 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810