Protein Alignment HDAC11 and HDAC3

DIOPT Version :10

• Sequence 1: NP_733048.1
• Gene: HDAC11 / 326120
• FlyBaseID: FBgn0051119
• Length: 343
• Species: Drosophila melanogaster
• Sequence 2: NP_001341968.1
• Gene: HDAC3 / 8841
• HGNCID: 4854
• Length: 434
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 83/310 - (26%)
• Similarity: 126/310 - (40%)
• Gaps: 72/310 - (23%)

  Fly    51 HPFDAAKGKHIHKL-LCAQLQLDDGSF-----YEPTELTKDQLRRIHTREYL------------- 96
            ||...      |:| |...|.|..|.:     ::|.:.::..:.|.|:.:|:
Human    22 HPMKP------HRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQG 80

  Fly    97 --KSLRWSMNVA--CIAEVPLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLALD---YGWAINLG 154
              |||. :.||.  |.....|..|. :||             .|:.|.|...|:   ...|||..
Human    81 FTKSLN-AFNVGDDCPVFPGLFEFC-SRY-------------TGASLQGATQLNNKICDIAINWA 130

  Fly   155 GGFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDF---NNVAAVY 216
            ||.||...:...|||...||.:.|:.|.:..|    |::.:|:|.|.|:|.:..|   :.|..|
Human   131 GGLHHAKKFEASGFCYVNDIVIGILELLKYHP----RVLYIDIDIHHGDGVQEAFYLTDRVMTV- 190

  Fly   217 IFDMYNAFVYPRD----HVAKESIR--CA-VELRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYN 274
            .|..|..:.:|..    .|..||.|  |. |.||:..:|..|....:..:.|.:..::|..:|..
Human   191 SFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQ 255

  Fly   275 AGTDVLEGDPLG--NLAISAEG-VIERDRLVFSTFRALGIPVVMLLSGGY 321
            .|.|.|..|.||  ||:|...| .:|       ..::..||:::|..|||
Human   256 CGADSLGCDRLGCFNLSIRGHGECVE-------YVKSFNIPLLVLGGGGY 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_733048.1	HDAC_classIV	51..336	CDD:212519	83/310 (27%)
HDAC3	NP_001341968.1	HDAC3	3..383	CDD:212529	83/310 (27%)
		Histone deacetylase	3..316		83/310 (27%)