Protein Alignment HDAC11 and HDA1

DIOPT Version :10

• Sequence 1: NP_733048.1
• Gene: HDAC11 / 326120
• FlyBaseID: FBgn0051119
• Length: 343
• Species: Drosophila melanogaster
• Sequence 2: NP_014377.1
• Gene: HDA1 / 855710
• SGDID: S000004966
• Length: 706
• Species: Saccharomyces cerevisiae
• Alignment Length: 313
• Identity: 73/313 - (23%)
• Similarity: 130/313 - (41%)
• Gaps: 59/313 - (18%)

  Fly    51 HPFDAAKGKHIHKLLCAQLQLDDGSFYEPT-----------------ELTKDQLRRIHTREYLKS 98
            ||.|..:...|:|:|.     ::|...:||                 ..|.:::..:||:|:|:.
Yeast    83 HPEDPRRIYRIYKILA-----ENGLINDPTLSGVDDLGDLMLKIPVRAATSEEILEVHTKEHLEF 142

  Fly    99 LRWSMNVA---CIAEVPLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLALD----YGWAINLGGG 156
            :..:..::   .:.|......|   |.........|....|:|.|.|..::    ...|:....|
Yeast   143 IESTEKMSREELLKETEKGDSV---YFNNDSYASARLPCGGAIEACKAVVEGRVKNSLAVVRPPG 204

  Fly   157 FHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDF-NNVAAVYI--- 217
             ||......||||.::::::....:.:..|..||||||:|.|.|.|||.::.| .:...:|:
Yeast   205 -HHAEPQAAGGFCLFSNVAVAAKNILKNYPESVRRIMILDWDIHHGNGTQKSFYQDDQVLYVSLH 268

  Fly   218 -FDM---YNAFV---YPRDHVAK-ESIRCAVELRNYT------EDGFYLRQLKRCLMQSLAEFRP 268
             |:|   |...:   |.:....| |...|     |.|      .|..|:...::.:|....||:|
Yeast   269 RFEMGKYYPGTIQGQYDQTGEGKGEGFNC-----NITWPVGGVGDAEYMWAFEQVVMPMGREFKP 328

  Fly   269 DMVVYNAGTDVLEGDPLGNLAISAEGVIERDRLVFSTFRALGIPVVMLLSGGY 321
            |:|:.::|.|..:||.:|...::.........::.|..|.   .:.::|.|||
Yeast   329 DLVIISSGFDAADGDTIGQCHVTPSCYGHMTHMLKSLARG---NLCVVLEGGY 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_733048.1	HDAC_classIV	51..336	CDD:212519	73/313 (23%)
HDA1	NP_014377.1	HDAC_Clr3	81..403	CDD:212542	73/313 (23%)
		Arb2	457..698	CDD:401634