DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC11 and HDA2

DIOPT Version :9

Sequence 1:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_568480.2	Gene:	HDA2 / 832673	AraportID:	AT5G26040	Length:	387	Species:	Arabidopsis thaliana

Alignment Length:	312	Identity:	155/312 - (49%)
Similarity:	205/312 - (65%)	Gaps:	2/312 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KLPIVFSRNYAVRFGGLERLHPFDAAKGKHIHKLLCAQLQLDDGSFYEPTELTKDQLRRIHTREY 95
            |:.|::|.:|.:.|.|:|:|||||::|...:.|.|.:...|::.:..||.|.:|..|..:|:..|
plant    73 KVSIIYSSSYDISFMGIEKLHPFDSSKWGRVCKFLVSDGFLEEKAIVEPLEASKIDLLVVHSENY 137

  Fly    96 LKSLRWSMNVACIAEVPLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLALDYGWAINLGGGFHHC 160
            |.||:.|..||.|.||..:||.||..:|:..|.|.|.|..|:|||.|||.:.|||||:|||||||
plant   138 LNSLKSSATVARITEVAPVAFFPNFLVQQKVLYPFRKQVGGTILAAKLATERGWAINIGGGFHHC 202

  Fly   161 CSYRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYIFDMYNAFV 225
            .:.||||||.:|||||.|...|.:  .|:.|:||:|||||||||||.|..:...|||.||||..:
plant   203 TAERGGGFCAFADISLCIHFAFLR--LRISRVMIIDLDAHQGNGHETDLGDDNRVYILDMYNPEI 265

  Fly   226 YPRDHVAKESIRCAVELRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEGDPLGNLAI 290
            ||.|:.|:..|...||:.:.|....|||:|...|..:...|:|::|:||||||:|:|||||.|.|
plant   266 YPFDYRARRFIDQKVEVMSGTTTDEYLRKLDEALEVASRNFQPELVIYNAGTDILDGDPLGLLKI 330

  Fly   291 SAEGVIERDRLVFSTFRALGIPVVMLLSGGYLKASAGVITDSIVNLRLQGLL 342
            |.:|:..||..||...|...||:|||.||||:|:||.||.|||.||..|||:
plant   331 SPDGITSRDEKVFRFAREKNIPLVMLTSGGYMKSSARVIADSIENLSRQGLI 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	142/284 (50%)
HDA2	NP_568480.2	HDAC_classIV	93..376	CDD:212519	142/284 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	253	1.000	Domainoid score	I511
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11743
Inparanoid	1	1.050	297	1.000	Inparanoid score	I803
OMA	1	1.010	-	-		QHG57761
OrthoDB	1	1.010	-	-		D1037375at2759
OrthoFinder	1	1.000	-	-		FOG0006007
OrthoInspector	1	1.000	-	-		oto4000
orthoMCL	1	0.900	-	-		OOG6_103672
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4306
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840