Protein Alignment HDAC11 and HDAC11

DIOPT Version :10

• Sequence 1: NP_733048.1
• Gene: HDAC11 / 326120
• FlyBaseID: FBgn0051119
• Length: 343
• Species: Drosophila melanogaster
• Sequence 2: NP_079103.2
• Gene: HDAC11 / 79885
• HGNCID: 19086
• Length: 347
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 163/310 - (52%)
• Similarity: 211/310 - (68%)
• Gaps: 1/310 - (0%)

  Fly    33 PIVFSRNYAVRFGGLERLHPFDAAKGKHIHKLLCAQLQLDDGSFYEPTELTKDQLRRIHTREYLK 97
            |||:|..|.:.|.|||:||||||.|...:...|..:..|.|....|..|.:::.|..:|||.||.
Human    17 PIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLN 81

  Fly    98 SLRWSMNVACIAEVPLMAFVPNRYIQRSYLRPMRFQAAGSILAGKLALDYGWAINLGGGFHHCCS 162
            .|:||..||.|.|:|.:.|:||..:||..|||:|.|..|:|:|||||::.|||||:|||||||.|
Human    82 ELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSS 146

  Fly   163 YRGGGFCPYADISLLIVRLFEQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYIFDMYNAFVYP 227
            .||||||.||||:|.|..|||:.. .:.|..|:||||||||||||||.:...|||.|:||..:||
Human   147 DRGGGFCAYADITLAIKFLFERVE-GISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYP 210

  Fly   228 RDHVAKESIRCAVELRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEGDPLGNLAISA 292
            .|..||::||..|||...|||..||.:::|.:.:||.|..||:||||||||:||||.||.|:||.
Human   211 GDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISP 275

  Fly   293 EGVIERDRLVFSTFRALGIPVVMLLSGGYLKASAGVITDSIVNLRLQGLL 342
            .|:::||.|||...|...:|::|:.||||.|.:|.:|.|||:||...||:
Human   276 AGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLI 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_733048.1	HDAC_classIV	51..336	CDD:212519	149/284 (52%)
HDAC11	NP_079103.2	Histone deacetylase	14..326		162/308 (53%)
		HDAC_classIV	35..319	CDD:212519	149/283 (53%)