DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC11 and Hdac9

DIOPT Version :9

Sequence 1:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_006515324.1	Gene:	Hdac9 / 79221	MGIID:	1931221	Length:	1100	Species:	Mus musculus

Alignment Length:	347	Identity:	88/347 - (25%)
Similarity:	132/347 - (38%)	Gaps:	102/347 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AGKLPIVFSRNYAVRFGGL----ER-------LHPFDAAKGKHIHKLLCAQLQLDDGSFYEPTEL 82
            ||::..::||   ::..||    ||       |........:| |.||.....| ||...:|..|
Mouse   692 AGRIQSIWSR---LQETGLLSKCERIQGRKASLEEIQLVHSEH-HSLLYGTSPL-DGQKLDPRTL 751

  Fly    83 TKDQLRRIHTREYLKSLR-----------WS---------MNVACIAEVPLMAFVPNRYIQRSYL 127
            ..|.     :|::..||.           |:         |.|.|:.|
Mouse   752 LGDD-----SRKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIE----------------- 794

  Fly   128 RPMRFQAAGSILAGKLA---LDYGWAINLGGGFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRV 189
                       ||.|:|   |..|:|:....| ||.......|||.:..:::....|.:|  ..:
Mouse   795 -----------LASKVASGELKNGFAVVRPPG-HHAEESAAMGFCFFNSVAITAKYLRDQ--LNI 845

  Fly   190 RRIMIVDLDAHQGNGHERDF-NNVAAVYI----FDMYNAFVYPRDHVAKE-----------SIRC 238
            .:|:|||||.|.|||.::.| .:.:.:||    :|..|.|  |......|           :|..
Mouse   846 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFF--PGSGAPNEVGVGLGEGYNVNIAW 908

  Fly   239 AVELRNYTEDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEG--DPLGNLAISAE--GVIERD 299
            ...|.....|..||...:..:|....||.||||:.:||.|.|||  .|||...::|:  |.:.:.
Mouse   909 TGGLDPPMGDVEYLEAFRTVVMPVAREFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQ 973

  Fly   300 RLVFSTFRALGIPVVMLLSGGY 321
            .:..:..|     |.:.|.||:
Mouse   974 LMTLANGR-----VALALEGGH 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	79/314 (25%)
Hdac9	XP_006515324.1	ClassIIa_HDAC9_Gln-rich-N	71..160	CDD:197399
Hdac9	XP_006515324.1	HDAC_classIIa	665..1042	CDD:212544	88/347 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900