DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC11 and hdac6

DIOPT Version :9

Sequence 1:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_009302026.1	Gene:	hdac6 / 565482	ZFINID:	ZDB-GENE-030131-3232	Length:	1081	Species:	Danio rerio

Alignment Length:	371	Identity:	100/371 - (26%)
Similarity:	169/371 - (45%)	Gaps:	68/371 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ERVHHEEQESEEVVWVKRDDARSAGKLPIVFSRNYAVRFGGL-ERLHPFDAAKGKHIHKLL---- 65
            :|...||:.|.|:..:.......|....:|:...: .||..| :..||...|:...:.::|
Zfish    37 DRSKAEEEMSNELQNLDVQGKSKATGTGLVYVDAF-TRFHCLWDASHPECPARVSTVMEMLETEG 100

  Fly    66 ----CAQLQLDDGSFYEPTELTKDQLRRIHTREYLKSLRWSMNVACIAEVPLMAFVPNRYIQRSY 126
                |.|:        |...:|:|:|..:||:||::.::.:.|:. ..|:..:|   .:| ...|
Zfish   101 LLGRCVQV--------EARAVTEDELLLVHTKEYVELMKSTQNMT-EEELKTLA---EKY-DSVY 152

  Fly   127 LRPMRFQAA----GSI--LAGKL---ALDYGWAINLGGGFHHCCSYRGGGFCPYADISLLIVRLF 182
            |.|..|.:|    ||:  |..|:   .|..|::||...| ||..:.:..|||.:.  :|.|...:
Zfish   153 LHPGFFSSACLSVGSVLQLVDKVMTSQLRNGFSINRPPG-HHAQADKMNGFCMFN--NLAIAARY 214

  Fly   183 EQEPFRVRRIMIVDLDAHQGNGHERDFNNVAAVYIFDMY---NAFVYPRDHVAKESIRCAVEL-- 242
            .|:..||:|::|||.|.|.|.|.:..|....:|..|.::   :...:|  |: |||...:|..
Zfish   215 AQKRHRVQRVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWP--HL-KESDSSSVGSGA 276

  Fly   243 -RNYT----------EDGFYLRQLKRCLMQSLAEFRPDMVVYNAGTDVLEGDPLGNLAISAEGVI 296
             :.|.          |.|.|:...::.|:....||:|.:|:..||.|.:.|||.|.:.:|.|
Zfish   277 GQGYNINLPWNKVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPE--- 338

  Fly   297 ERDRLVFS--TFRALGIP---VVMLLSGGY-LKASAGVITDSIVNL 336
                 .||  |....|:.   :|:.|.||| |:::|..:..|:.:|
Zfish   339 -----CFSILTHMLKGVAQGRLVLALEGGYNLQSTAEGVCASMRSL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	89/323 (28%)
hdac6	XP_009302026.1	HDAC6-dom1	76..412	CDD:212545	91/331 (27%)
		HDAC6-dom2	448..798	CDD:212527
		zf-UBP	999..1061	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810