DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC11 and hdac11

DIOPT Version :9

Sequence 1:	NP_001247296.1	Gene:	HDAC11 / 326120	FlyBaseID:	FBgn0051119	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_021335266.1	Gene:	hdac11 / 431718	ZFINID:	ZDB-GENE-040704-7	Length:	375	Species:	Danio rerio

Alignment Length:	346	Identity:	166/346 - (47%)
Similarity:	217/346 - (62%)	Gaps:	26/346 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HHEEQESEEVVWVKRDDARSAGKLPIVFSRNYAVRFGGLERLHPFDAAKGKHIHKLLCAQLQLDD 73
            ||.|..:|.          .|..||||:|..|.:.|.|||:||||||.|...:.:.|..:..:.|
Zfish    14 HHTELYAEV----------PASCLPIVYSPEYNITFMGLEKLHPFDAGKWGKVIRFLKEEQFITD 68

  Fly    74 GSFYEPTELTKDQLRRIHTREYLKSLR---------WSMNVACIAEVPLMAFVPNRYIQRSYLRP 129
            .......|.::..|..:||..||..|:         ||:.||.|.|:|.:.|:||..:||..|||
Zfish    69 EIIVLAREASEADLLVVHTARYLNRLKNAILEGSREWSLVVATITEIPPLLFLPNFLVQRKVLRP 133

  Fly   130 MRFQAAGSILAGKLALDYGWAINLGGGFHHCCSYRGGGFCPYADISLLIVRLFEQEPFRVRRI-- 192
            :|.|..|:|:|||||:|.|||||:|||||||.|.:|||||.||||:|.|..|||    ||..:
Zfish   134 LRTQTGGTIMAGKLAIDRGWAINVGGGFHHCSSDKGGGFCAYADITLAIKFLFE----RVEGVAS 194

  Fly   193 -MIVDLDAHQGNGHERDFNNVAAVYIFDMYNAFVYPRDHVAKESIRCAVELRNYTEDGFYLRQLK 256
             .|:||||||||||||||.....|||.|:||..:||.|..||.:|:..|||...|||..||:::.
Zfish   195 ATIIDLDAHQGNGHERDFLEDRRVYIMDVYNRHIYPGDGYAKRAIKRKVELDWGTEDSEYLQKVD 259

  Fly   257 RCLMQSLAEFRPDMVVYNAGTDVLEGDPLGNLAISAEGVIERDRLVFSTFRALGIPVVMLLSGGY 321
            .....:|.|.|||:::||||||:|:|||||.||||.:|:|:||.::|...|..|||::|:.||||
Zfish   260 LHSEGALNEARPDIIIYNAGTDILDGDPLGGLAISPQGIIKRDEIIFRAARRRGIPILMVTSGGY 324

  Fly   322 LKASAGVITDSIVNLRLQGLL 342
            .|.:|.:|.|||:||..|||:
Zfish   325 QKKTARIIADSILNLHRQGLI 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC11	NP_001247296.1	HDAC_classIV	51..336	CDD:212519	145/296 (49%)
hdac11	XP_021335266.1	HDAC_classIV	46..339	CDD:212519	145/296 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594751
Domainoid	1	1.000	275	1.000	Domainoid score	I1725
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11743
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2531
OMA	1	1.010	-	-		QHG57761
OrthoDB	1	1.010	-	-		D1037375at2759
OrthoFinder	1	1.000	-	-		FOG0006007
OrthoInspector	1	1.000	-	-		oto41555
orthoMCL	1	0.900	-	-		OOG6_103672
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3706
SonicParanoid	1	1.000	-	-		X4306
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940